Search Results - "EL HARCHI, A."

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation by Hancox, J.C., PhD, FSB, FBPharmacolS, Kharche, S., PhD, El Harchi, A., PhD, Stott, J., PhD, Law, P., PhD, Zhang, H., PhD

“…Abstract Mutations in transmembrane domains of the KCNQ1 subunit of the IKs potassium channel have been associated with familial atrial fibrillation. We have…”
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Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform by Du, C.Y., El Harchi, A., McPate, M.J., Orchard, C.H., Hancox, J.C.

“…► We investigate how different hERG K + channel isoforms respond to extracellular acidosis. ► Acidosis produces greater inhibition of hERG channels…”
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Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation by El Harchi, A, McPate, M J, Zhang, Y H, Zhang, H, Hancox, J C

“…The slow delayed rectifier potassium current, 'I(Ks)', contributes to repolarisation of cardiac ventricular action potentials and thereby to the duration of…”
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Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis by DU, C.Y., EL HARCHI, A., ZHANG, Y.H., ORCHARD, C.H., HANCOX, J.C.

“…Acidosis and hERG K+ Channel Pharmacology.  Introduction: Human Ether‐à‐go‐go related gene (hERG) is responsible for channels that mediate the rapid delayed…”
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Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart by Le Bouter, Sabrina, El Harchi, Aziza, Marionneau, Céline, Bellocq, Chloé, Chambellan, Arnaud, van Veen, Toon, Boixel, Christophe, Gavillet, Bruno, Abriel, Hugues, Le Quang, Khai, Chevalier, Jean-Christophe, Lande, Gilles, Léger, Jean J, Charpentier, Flavien, Escande, Denis, Demolombe, Sophie

“…The basis for the unique effectiveness of long-term amiodarone treatment on cardiac arrhythmias is incompletely understood. The present study investigated the…”
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G002 Transfer of rolf S3-S4 linker to hERG eliminates activation gating but spares inactivation by Choveau, F, El Harchi, A, Rodriguez, N, Louerat-Oriou, B, Baró, I, Demolombe, S, Charpentier, F, Lousouarn, G

“…A recent study in Shaker, a voltage-dependent potassium channel, suggests a coupling between activation and inactivation. This coupling is controversial in…”
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Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity by ROYER, Anne, DEMOLOMBE, Sophie, MOTOIKE, Howard K, CHEVALLIER, Jean-Christophe, LOUSSOUAM, Gildas, CLANCY, Colleen E, ESCANDE, Denis, CHARPENTIER, Flavien, AZIZA EL HARCHI, KHAÏ LE QUANG, PIRON, Julien, TOUMANIANTZ, Gilles, MAZURAIS, David, BELLOCQ, Chloé, LANDE, Gilles, TERRENOIRE, Cécile

“…The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of…”
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The S140G KCNQ1 atrial fibrillation mutation affects 'I(KS)' profile during both atrial and ventricular action potentials by El Harchi, A, Zhang, H, Hancox, J C

“…KCNQ1 is responsible for the pore-forming subunit of channels that mediate the cardiac 'IKs' potassium channel current. The S140G KCNQ1 gain-of-function…”
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