Search Results - "EKBLOM, Marja"

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells by Qian, Hong, Buza-Vidas, Natalija, Hyland, Craig D, Jensen, Christina T, Antonchuk, Jennifer, Månsson, Robert, Thoren, Lina A, Ekblom, Marja, Alexander, Warren S, Jacobsen, Sten Eirik W

“…The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly understood. Herein we demonstrate that thrombopoietin (THPO) and its…”
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Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow by Li, Hongzhe, Ghazanfari, Roshanak, Zacharaki, Dimitra, Ditzel, Nicholas, Isern, Joan, Ekblom, Marja, Méndez-Ferrer, Simón, Kassem, Moustapha, Scheding, Stefan

“…Human bone marrow (BM) contains a rare population of nonhematopoietic mesenchymal stromal cells (MSCs), which are of central importance for the hematopoietic…”
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Laminin isoforms in development and disease by SCHEELE, Susanne, NYSTRÖM, Alexander, DURBEEJ, Madeleine, TALTS, Jan F, EKBLOM, Marja, EKBLOM, Peter

“…The members of the laminin family of heterotrimers are major constituents of all basement membranes, sheet-like extracellular structures, present in almost all…”
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Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions by Qian, Hong, Johansson, Sophie, McCourt, Peter, Smedsrød, Bård, Ekblom, Marja, Johansson, Staffan

“…Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells…”
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Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice by Xiao, Pingnan, Sandhow, Lakshmi, Heshmati, Yaser, Kondo, Makoto, Bouderlique, Thibault, Dolinska, Monika, Johansson, Anne-Sofie, Sigvardsson, Mikael, Ekblom, Marja, Walfridsson, Julian, Qian, Hong

“…Despite increasing evidence for the involvement of bone marrow (BM) hematopoietic stem cell niche in leukemogenesis, how BM mesenchymal stem and progenitor…”
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Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells by Qian, Hong, Georges-Labouesse, Elisabeth, Nyström, Alexander, Domogatskaya, Anna, Tryggvason, Karl, Jacobsen, Sten Eirik W., Ekblom, Marja

“…Homing of hematopoietic stem cells (HSCs) into the bone marrow (BM) is a prerequisite for establishment of hematopoiesis during development and following…”
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Laminin isoform–specific promotion of adhesion and migration of human bone marrow progenitor cells by Gu, Yu-Chen, Kortesmaa, Jarkko, Tryggvason, Karl, Persson, Jenny, Ekblom, Peter, Jacobsen, Sten-Eirik, Ekblom, Marja

“…Laminins are αβγ heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. Laminins containing…”
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Disease Relapse After TKI Discontinuation In CML Is Related Both To Low Number and Impaired Function Of NK-Cells:Data From Euro-SKI by Ilander, Mette Matilda, Olsson-Strömberg, Ulla, Lähteenmäki, Hanna, Kasanen, Tiina, Koskenvesa, Perttu, Söderlund, Stina, Hoglund, Martin, Markevärn, Berit, Själander, Anders, Lofti, Kourosh, Malm, Claes, Lubking, Anna, Ekblom, Marja, Holm, Elena, Björeman, Mats, Lehmann, Sören, Stenke, Leif, Ohm, Lotta, Hjorth-Hansen, Henrik, Saussele, Susanne, Mahon, Francois-Xavier, Porkka, Kimmo, Richter, Johan, Mustjoki, Satu

“…The inhibition of oncogenic BCR-ABL1 kinase with tyrosine kinase inhibitors (TKIs) has significantly improved the prognosis of CML. Recent reports suggest that…”
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Laminin Isoforms and Epithelial Development by EKBLOM, MARJA, FALK, MATS, SALMIVIRTA, KATRIINA, DURBEEJ, MADELEINE, EKBLOM, PETER

“…Several different approaches suggest that basement‐membrane assembly is important for epithelial development. Basement membranes contain isoforms of collagen…”
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Role of mesenchymal nidogen for epithelial morphogenesis in vitro by EKBLOM, P, EKBLOM, M, FECKER, L, KLEIN, G, HONG-YAN ZHANG, KADOYA, Y, MON-LI CHU, MAYER, U, TIMPL, R

“…Recent biochemical studies suggested that the extracellular matrix protein nidogen is a binding molecule linking together basement membrane components. We…”
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Expression of laminin α1, α5 and β2 chains during embryogenesis of the kidney and vasculature by Durbeej, Madeleine, Fecker, Lothar, Hjalt, Tord, Zhang, Hong-Yan, Salmivirta, Kátriina, Klein, Gerd, Timpl, Rupert, Sorokin, Lydia, Ebendal, Ted, Ekblom, Peter, Ekblom, Marja

“…Laminins, found predominantly in basement membranes, are large glycoproteins consisting of different subsets of α, β and γ chain subunits. To resolve…”
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Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression by Cai, Huan, Kondo, Makoto, Sandhow, Lakshmi, Xiao, Pingnan, Johansson, Anne-Sofie, Sasaki, Takako, Zawacka-Pankau, Joanna, Tryggvason, Karl, Ungerstedt, Johanna, Walfridsson, Julian, Ekblom, Marja, Qian, Hong

“…Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM)…”
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cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA by Olsson, Magnus, Ekblom, Marja, Fecker, Lothar, Kurkinen, Markku, Ekblom, Peter

“…cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA. In embryonic kidneys, mesenchymal cells convert into epithelium in…”
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Transient and locally restricted expression of laminin A chain mRNA by developing epithelial cells during kidney organogenesis by Ekblom, M, Klein, G, Mugrauer, G, Fecker, L, Deutzmann, R, Timpl, R, Ekblom, P

“…Three polypeptide chains, A, B1, and B2, have been described for mouse laminin, a basement membrane protein. We studied expression of laminin A, B1, and B2…”
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Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy by Kreutzman, Anna, Juvonen, Vesa, Kairisto, Veli, Ekblom, Marja, Stenke, Leif, Seggewiss, Ruth, Porkka, Kimmo, Mustjoki, Satu

“…In a proportion of patients with chronic myeloid leukemia (CML) being treated with dasatinib, we recently observed large granular lymphocyte (LGL) expansions…”
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Characterization of Bone Marrow Niche in Chronic Myeloid Leukemia Patients Identifies CXCL14 as a New Therapeutic Option by Dolinska, Monika, Cai, Huan, Mansson, Alma, Shen, Jingyi, Xiao, Pingnan, Bouderlique, Thibault, Li, Xidan, Leonard, Elory, Chang, Marcus, Gao, Yuchen, Medina Giménez, Juan Pablo, Kondo, Makoto, Sandhow, Lakshmi, Johansson, Anne-Sofie, Deneberg, Stefan, Söderlund, Stina, Jädersten, Martin, Ungerstedt, Johanna S, Tobiasson, Magnus, Östman, Arne, Mustjoki, Satu, Stenke, Leif, Le Blanc, Katarina, Hellstrom-Lindberg, Eva S, Lehmann, Sören, Ekblom, Marja, Olsson-Strömberg, Ulla, Sigvardsson, Mikael, Qian, Hong

“…Although tyrosine kinase inhibitors are effective for treating chronic myeloid leukemia (CML), they often fail to eradicate the leukemia-initiating stem cells…”
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Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry by Höglund, Martin, Sandin, Fredrik, Hellström, Karin, Björeman, Mats, Björkholm, Magnus, Brune, Mats, Dreimane, Arta, Ekblom, Marja, Lehmann, Sören, Ljungman, Per, Malm, Claes, Markevärn, Berit, Myhr-Eriksson, Kristina, Ohm, Lotta, Olsson-Strömberg, Ulla, Själander, Anders, Wadenvik, Hans, Simonsson, Bengt, Stenke, Leif, Richter, Johan

“…Clinical management guidelines on malignant disorders are generally based on data from clinical trials with selected patient cohorts. In Sweden, more than 95%…”
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Clonal expansion of T NK-cells during tyrosine kinase inhibitor dasatinib therapy by Mustjoki, S, Ekblom, M, Arstila, T P, Dybedal, I, Epling-Burnette, P K, Guilhot, F, Hjorth-Hansen, H, Höglund, M, Kovanen, P, Laurinolli, T, Liesveld, J, Paquette, R, Pinilla-Ibarz, J, Rauhala, A, Shah, N, Simonsson, B, Sinisalo, M, Steegmann, J L, Stenke, L, Porkka, K

“…Dasatinib, a broad-spectrum tyrosine kinase inhibitor (TKI), predominantly targets BCR-ABL and SRC oncoproteins and also inhibits off-target kinases, which may…”
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Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option by Dolinska, Monika, Cai, Huan, Månsson, Alma, Shen, Jingyi, Xiao, Pingnan, Bouderlique, Thibault, Li, Xidan, Leonard, Elory, Chang, Marcus, Gao, Yuchen, Medina, Juan Pablo, Kondo, Makoto, Sandhow, Lakshmi, Johansson, Anne-Sofie, Deneberg, Stefan, Söderlund, Stina, Jädersten, Martin, Ungerstedt, Johanna, Tobiasson, Magnus, Östman, Arne, Mustjoki, Satu, Stenke, Leif, Le Blanc, Katarina, Hellström-Lindberg, Eva, Lehmann, Sören, Ekblom, Marja, Olsson-Strömberg, Ulla, Sigvardsson, Mikael, Qian, Hong

“…•CXCL14 is lost in BM stromal cells in patients with CML, and restoring CXCL14 suppresses CML LSC engraftment in vivo and survival in vitro.•CXCL14 treatment…”
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Expansion of highly differentiated CD8 T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation by Kreutzman, A, Ladell, K, Koechel, C, Gostick, E, Ekblom, M, Stenke, L, Melo, T, Einsele, H, Porkka, K, Price, D A, Mustjoki, S, Seggewiss, R

“…The tyrosine kinase inhibitor dasatinib exerts immunosuppressive effects on T-cells and NK-cells in vitro . However, in some dasatinib-treated leukemia…”
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