Search Results - "EJIM, Linda"

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy by Ejim, Linda, Farha, Maya A, Falconer, Shannon B, Wildenhain, Jan, Coombes, Brian K, Tyers, Mike, Brown, Eric D, Wright, Gerard D

“…The systematic exploration of off-patent drugs in combination with the antibiotic minocycline uncovers unexpected synergies in antibiotic-nonantibiotic pairs…”
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Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole by Spitzer, Michaela, Griffiths, Emma, Blakely, Kim M, Wildenhain, Jan, Ejim, Linda, Rossi, Laura, De Pascale, Gianfranco, Curak, Jasna, Brown, Eric, Tyers, Mike, Wright, Gerard D

“…Resistance to widely used fungistatic drugs, particularly to the ergosterol biosynthesis inhibitor fluconazole, threatens millions of immunocompromised…”
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Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes by Cox, Georgina, Ejim, Linda, Stogios, Peter J., Koteva, Kalinka, Bordeleau, Emily, Evdokimova, Elena, Sieron, Arthur O., Savchenko, Alexei, Serio, Alisa W., Krause, Kevin M., Wright, Gerard D.

“…Plazomicin is a next-generation, semisynthetic aminoglycoside antibiotic currently under development for the treatment of infections due to multidrug-resistant…”
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Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr by Baysarowich, Jennifer, Koteva, Kalinka, Hughes, Donald W, Ejim, Linda, Griffiths, Emma, Zhang, Kun, Junop, Murray, Wright, Gerard D

“…The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus. Recent…”
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Diversity of Integron- and Culture-Associated Antibiotic Resistance Genes in Freshwater Floc by DRUDGE, Christopher N, ELLIOTT, Amy V. C, PLACH, Janina M, EJIM, Linda J, WRIGHT, Gerard D, DROPPO, Ian G, WARREN, Lesley A

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Isolation of flavonoids from the heartwood and resin of Prunus avium and some preliminary biological investigations by McNulty, James, Nair, Jerald J., Bollareddy, Endreddy, Keskar, Kunal, Thorat, Amol, Crankshaw, Denis J., Holloway, Alison C., Khan, Ghaznia, Wright, Gerard D., Ejim, Linda

“…An investigation of the constituents in heartwood and resin of Prunus avium is reported. A mini-library of structurally diverse flavanones and flavones was…”
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Cystathionine β-Lyase Is Important for Virulence of Salmonella enterica Serovar Typhimurium by EJIM, Linda J, D'COSTA, Vanessa M, ELOWE, Nadine H, LOREDO-OSTI, J. Conception, MALO, Danielle, WRIGHT, Gerard D

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Inhibitors of Bacterial Cystathionine β-Lyase:  Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function by Ejim, Linda J, Blanchard, Jan E, Koteva, Kalinka P, Sumerfield, Rachael, Elowe, Nadine H, Chechetto, Jonathan D, Brown, Eric D, Junop, Murray S, Wright, Gerard D

“…The biosynthesis of methionine is an attractive antibiotic target given its importance in protein and DNA metabolism and its absence in mammals. We have…”
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New phenolic inhibitors of yeast homoserine dehydrogenase by Ejim, Linda, Mirza, I.Ahmad, Capone, Christina, Nazi, Ishac, Jenkins, Steve, Chee, Gaik-Lean, Berghuis, Albert M, Wright, Gerard D

“…Graphic A relatively unexploited potential target for antimicrobial agents is the biosynthesis of essential amino acids. Homoserine dehydrogenase, which…”
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The Comprehensive Antibiotic Resistance Database by MCARTHUR, Andrew G, WAGLECHNER, Nicholas, KALAN, Lindsay, KING, Andrew M, KOTEVA, Kalinka, MORAR, Mariya, MULVEY, Michael R, O'BRIEN, Jonathan S, PAWLOWSKI, Andrew C, PIDDOCK, Laura J. V, SPANOGIANNOPOULOS, Peter, SUTHERLAND, Arlene D, NIZAM, Fazmin, TANG, Irene, TAYLOR, Patricia L, THAKER, Maulik, WENLIANG WANG, YAN, Marie, YU, Tennison, WRIGHT, Gerard D, YAN, Austin, AZAD, Marisa A, BAYLAY, Alison J, BHULLAR, Kirandeep, CANOVA, Marc J, DE PASCALE, Gianfranco, EJIM, Linda

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Isomerization of bioactive acylhydrazones triggered by light or thiols by Zhang, Zhiwei, Le, Giang N. T., Ge, Yang, Tang, Xiaowen, Chen, Xin, Ejim, Linda, Bordeleau, Emily, Wright, Gerard D., Burns, Darcy C., Tran, Susannah, Axerio-Cilies, Peter, Wang, Yu Tian, Dong, Mingxin, Woolley, G. Andrew

“…The acylhydrazone unit is well represented in screening databases used to find ligands for biological targets, and numerous bioactive acylhydrazones have been…”
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Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β‑Lactams by Farha, Maya A, Leung, Alexander, Sewell, Edward W, D’Elia, Michael A, Allison, Sarah E, Ejim, Linda, Pereira, Pedro M, Pinho, Mariana G, Wright, Gerard D, Brown, Eric D

“…Rising drug resistance is limiting treatment options for infections by methicillin-resistant Staphylococcus aureus (MRSA). Herein we provide new evidence that…”
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Discovery of Ibomycin, a Complex Macrolactone that Exerts Antifungal Activity by Impeding Endocytic Trafficking and Membrane Function by Robbins, Nicole, Spitzer, Michaela, Wang, Wenliang, Waglechner, Nicholas, Patel, Dhruv J, O'Brien, Jonathan S, Ejim, Linda, Ejim, Obi, Tyers, Mike, Wright, Gerard D

“…Natural products are invaluable historic sources of drugs for infectious diseases; however, the discovery of novel antimicrobial chemical scaffolds has waned…”
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A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome by Shakya, Tushar, Stogios, Peter J., Waglechner, Nicholas, Evdokimova, Elena, Ejim, Linda, Blanchard, Jan E., McArthur, Andrew G., Savchenko, Alexei, Wright, Gerard D.

“…Kinase-mediated resistance to antibiotics is a significant clinical challenge. These enzymes share a common protein fold characteristic of Ser/Thr/Tyr protein…”
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Epoxynemanione A, nemanifuranones A–F, and nemanilactones A–C, from Nemania serpens, an endophytic fungus isolated from Riesling grapevines by Ibrahim, Ashraf, Sørensen, Dan, Jenkins, Hilary A., Ejim, Linda, Capretta, Alfredo, Sumarah, Mark W.

“…Ten polyketide specialized metabolites, epoxynemanione A, nemanifuranones A–F, and nemanilactones A–C, were isolated from the culture filtrate of Nemania…”
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Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory by Cook, Michael A, Pallant, Daniel, Ejim, Linda, Sutherland, Arlene D, Wang, Xiaodong, Johnson, Jarrod W, McCusker, Susan, Chen, Xuefei, George, Maya, Chou, Sommer, Koteva, Kalinka, Wang, Wenliang, Hobson, Christian, Hackenberger, Dirk, Waglechner, Nicholas, Ejim, Obi, Campbell, Tracey, Medina, Ricardo, MacNeil, Lesley T, Wright, Gerard D

“…Abstract   Microbial natural products are specialized metabolites that are sources of many bioactive compounds including antibiotics, antifungals,…”
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Epoxynemanione A, nemanifuranones A–F, and nemanilactones A–C, from Nemania serpens, an endophytic fungus isolated from Riesling grapevines by Ibrahim, Ashraf, Sørensen, Dan, Jenkins, Hilary A., Ejim, Linda, Capretta, Alfredo, Sumarah, Mark W.

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Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer by Jacques, Suzanne L., Ejim, Linda J., Wright, Gerard D.

“…Homoserine dehydrogenase (HSD), which is required for the synthesis of threonine, isoleucine and methionine in fungi, is a potential target for novel…”
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Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia by Hider, R C, Ejim, L, Taylor, P D, Gale, R, Huehns, E, Porter, J B

“…The ability of a number of heterocyclic metal chelators to deliver zinc into red cells, to release the liganded zinc to haemoglobin and thereby cause a left…”
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Enzyme-Assisted Suicide by Jacques, Suzanne L, Mirza, I.Ahmad, Ejim, Linda, Koteva, Kalinka, Hughes, Donald W, Green, Kirk, Kinach, Robert, Honek, John F, Lai, Hoi Kiong, Berghuis, Albert M, Wright, Gerard D

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