Search Results - "EITAN BIBI"

Is there a twist in the Escherichia coli signal recognition particle pathway? by Bibi, Eitan

“…Integral membrane proteins (IMPs) are usually synthesized by membrane-bound ribosomes, and this process requires proper localization of ribosomes and…”
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Bacterial multidrug transport through the lens of the major facilitator superfamily by Fluman, Nir, Bibi, Eitan

“…Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells…”
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mRNA-programmed translation pauses in the targeting of E. coli membrane proteins by Fluman, Nir, Navon, Sivan, Bibi, Eitan, Pilpel, Yitzhak

“…In all living organisms, ribosomes translating membrane proteins are targeted to membrane translocons early in translation, by the ubiquitous signal…”
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Mutational scanning reveals the determinants of protein insertion and association energetics in the plasma membrane by Elazar, Assaf, Weinstein, Jonathan, Biran, Ido, Fridman, Yearit, Bibi, Eitan, Fleishman, Sarel Jacob

“…Insertion of helix-forming segments into the membrane and their association determines the structure, function, and expression levels of all plasma membrane…”
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Structural basis for intramembrane proteolysis by rhomboid serine proteases by Ben-Shem, Adam, Fass, Deborah, Bibi, Eitan

“…Intramembrane proteases catalyze peptide bond cleavage of integral membrane protein substrates. This activity is crucial for many biological and pathological…”
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The fascinating but mysterious mechanistic aspects of multidrug transport by MdfA from Escherichia coli by Yardeni, Eliane H., Zomot, Elia, Bibi, Eitan

“…MdfA is an interesting member of a large group of secondary multidrug (Mdr) transporters. Through genetic, biochemical and biophysical studies of MdfA, many…”
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The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters by Yardeni, Eliane H., Mishra, Smriti, Stein, Richard A., Bibi, Eitan, Mchaourab, Hassane S.

“…The prototypic multidrug (Mdr) transporter MdfA from Escherichia coli efflux chemically‐ dissimilar substrates in exchange for protons. Similar to other…”
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Studying Membrane Proteins through the Eyes of the Genetic Code Revealed a Strong Uracil Bias in Their Coding mRNAs by Prilusky, Jaime, Bibi, Eitan, Kaback, H. Ronald

“…Posttranscriptional processes often involve specific signals in mRNAs. Because mRNAs of integral membrane proteins across evolution are usually translated at…”
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A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter by Zomot, Elia, Yardeni, Eliane Hadas, Vargiu, Attilio Vittorio, Tam, Heng-Keat, Malloci, Giuliano, Ramaswamy, Venkata Krishnan, Perach, Michal, Ruggerone, Paolo, Pos, Klaas Martinus, Bibi, Eitan

“…Secondary multidrug (Mdr) transporters utilize ion concentration gradients to actively remove antibiotics and other toxic compounds from cells. The model Mdr…”
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Evidence for a cytoplasmic pool of ribosome-free mRNAs encoding inner membrane proteins in Escherichia coli by Benhalevy, Daniel, Biran, Ido, Bochkareva, Elena S, Sorek, Rotem, Bibi, Eitan

“…Translation-independent mRNA localization represents an emerging concept in cell biology. In Escherichia coli, mRNAs encoding integral membrane proteins (MPRs)…”
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Model Uracil-Rich RNAs and Membrane Protein mRNAs Interact Specifically with Cold Shock Proteins in Escherichia coli by Benhalevy, Daniel, Bochkareva, Elena S, Biran, Ido, Bibi, Eitan

“…Are integral membrane protein-encoding mRNAs (MPRs) different from other mRNAs such as those encoding cytosolic mRNAs (CPRs)? This is implied from the emerging…”
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Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA by Tirosh, Osnat, Sigal, Nadejda, Gelman, Amir, Sahar, Nadav, Fluman, Nir, Siemion, Shira, Bibi, Eitan

“…Multidrug transporters are integral membrane proteins that use cellular energy to actively extrude antibiotics and other toxic compounds from cells. The…”
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Escherichia coli Signal Recognition Particle Receptor FtsY Contains an Essential and Autonomous Membrane-binding Amphipathic Helix by Parlitz, Richard, Eitan, Asa, Stjepanovic, Goran, Bahari, Liat, Bange, Gert, Bibi, Eitan, Sinning, Irmgard

“…Escherichia coli membrane protein biogenesis is mediated by a signal recognition particle and its membrane-associated receptor (FtsY). Although crucial for its…”
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Export of a single drug molecule in two transport cycles by a multidrug efflux pump by Fluman, Nir, Adler, Julia, Rotenberg, Susan A., Brown, Melissa H., Bibi, Eitan

“…Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug…”
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The Secondary Multidrug/Proton Antiporter MdfA Tolerates Displacements of an Essential Negatively Charged Side Chain by Sigal, Nadejda, Fluman, Nir, Siemion, Shira, Bibi, Eitan

“…The largest family of solute transporters includes ion motive force-driven secondary transporters. Several well characterized solute-specific transport systems…”
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Promiscuity in multidrug recognition and transport:
 the bacterial MFS Mdr transporters by Lewinson, Oded, Adler, Julia, Sigal, Nadejda, Bibi, Eitan

“…Summary Multidrug (Mdr) transport is an obstacle to the successful treatment of cancer and infectious diseases, and it is mediated by Mdr transporters that…”
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Alkalitolerance: A Biological Function for a Multidrug Transporter in pH Homeostasis by Lewinson, Oded, Padan, Etana, Bibi, Eitan, Kaback, H. Ronald

“…MdfA is an Escherichia coli multidrug-resistance transporter. Cells expressing MdfA from a multicopy plasmid exhibit multidrug resistance against a diverse…”
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A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA by Fluman, Nir, Cohen-Karni, Devora, Weiss, Tali, Bibi, Eitan

“…Multidrug (Mdr) transporters are membrane proteins that actively export structurally dissimilar drugs from the cell, thereby rendering the cell resistant to…”
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Determinants of Substrate Recognition by the Escherichia coli Multidrug Transporter MdfA Identified on Both Sides of the Membrane by Adler, Julia, Bibi, Eitan

“…The Escherichia coli multidrug transporter MdfA contains a membrane-embedded charged residue (Glu-26) that was shown to play an important role in substrate…”
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Membrane protein biogenesis in Ffh- or FtsY-depleted Escherichia coli by Yosef, Ido, Bochkareva, Elena S, Adler, Julia, Bibi, Eitan

“…The Escherichia coli version of the mammalian signal recognition particle (SRP) system is required for biogenesis of membrane proteins and contains two…”
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