Search Results - "EISERMANN, Mona"

Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models by SANTEL, Ansgar, ALEKU, Manuela, EISERMANN, Mona, LÖFFLER, Kathrin, FECHTNER, Melanie, FISCH, Gerald, VANK, Christiane, SCHAEPER, Ute, GIESE, Klaus, KAUFMANN, Jörg, RÖDER, Nadine, MÖPERT, Kristin, DURIEUX, Birgit, JANKE, Oliver, KEIL, Oliver, ENDRUSCHAT, Jens, DAMES, Sibylle, LANGE, Christian

“…Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. The aim of this study…”
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SLN124, a GalNAc‐siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1 by Altamura, Sandro, Schaeper, Ute, Dames, Sibylle, Löffler, Kathrin, Eisermann, Mona, Frauendorf, Christian, Müdder, Katja, Neves, Joana, Muckenthaler, Martina U.

“…Supplemental Digital Content is available in the text…”
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Preclinical Toxicological Assessment of A Novel siRNA, SLN360, Targeting Elevated Lipoprotein (a) in Cardiovascular Disease by Rider, David, Chivers, Simon, Aretz, Julia, Eisermann, Mona, Löffler, Kathrin, Hauptmann, Judith, Morrison, Eliot, Campion, Giles

“…Abstract SLN360 is a liver-targeted N-acetyl galactosamine (GalNAc)-conjugated small interfering RNA (siRNA) with a promising profile for addressing…”
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Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease by Rider, David A., Eisermann, Mona, Löffler, Kathrin, Aleku, Manuela, Swerdlow, Daniel I., Dames, Sibylle, Hauptmann, Judith, Morrison, Eliot, Lindholm, Marie Wikström, Schubert, Steffen, Campion, Giles

“…The LPA gene encodes apolipoprotein (a), a key component of Lp(a), a potent risk factor for cardiovascular disease with no specific pharmacotherapy. Here we…”
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SLN124, a GalNac‐siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron‐overload in a mouse model of β‐thalassaemia by Vadolas, Jim, Ng, Garrett Z., Kysenius, Kai, Crouch, Peter J., Dames, Sibylle, Eisermann, Mona, Nualkaew, Tiwaporn, Vilcassim, Shahla, Schaeper, Ute, Grigoriadis, George

“…Summary Beta‐thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin expression is reduced…”
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Therapeutic Small Interfering RNA Targeting Complement C3 in a Mouse Model of C3 Glomerulopathy by Zanchi, Cristina, Locatelli, Monica, Cerullo, Domenico, Aumiller, Verena, Corna, Daniela, Rottoli, Daniela, Eisermann, Mona, Donadelli, Roberta, Mousavi, Mansoureh, Noris, Marina, Remuzzi, Giuseppe, Benigni, Ariela, Zoja, Carlamaria

“…Alternative pathway complement dysregulation with abnormal glomerular C3 deposits and glomerular damage is a key mechanism of pathology in C3 glomerulopathy…”
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Abstract 14720: Pre-clinical Safety Assessment of SLN360, a Novel Short Interfering Ribonucleic Acid Targeting LPA by Rider, David, Swerdlow, Daniel, Eisermann, Mona, Loeffler, Kathrin, Hauptmann, Judith, Morrison, Eliot, Wikstrom Lindholm, Marie, Schubert, Steffen, Campion, Giles

“…IntroductionSLN360 is a liver-targeted N-acetyl galactosamine (GalNAc)-conjugated siRNA with a promising profile for addressing Lp(a)-related cardiovascular…”
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SLN140 a Small Interfering RNA Targeting Protein S Improves Hemostasis Potency in Hemophilia by Prince, Raja Eladnani, Schaeper, Ute, Aretz, Julia, Li, Bojun, Reina Caro, Maria Desiré, vrotniakaite-Bajerciene, Kristina, Eisermann, Mona, Dames, Sibylle, Löffner, Kathrin, Martinez, Alberto, Laffan, Michael, Ahnstrom, Josefin, Angelillo-Scherrer, Anne

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Targeting Protein S Using Small Interfering RNA Is Well Tolerated and Protects Mice with Hemophilia a from Acute Hemarthrosis by Prince, Raja Eladnani, Schaeper, Ute, Dames, Sibylle, Calzavarini, Sara, Quarroz, Claudia, Reina Caro, Maria Desiré, Chanfon Bätzner, Astrid, Löffner, Kathrin, Eisermann, Mona, Angelillo-Scherrer, Anne

“…Introduction & Aim: Hemophilia A (HA) is an X-linked disorder caused by an absence or a reduction of coagulation factor VIII. Patients with HA often suffer…”
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Abstract 9538: A Novel Short Interfering Ribonucleic Acid Shows Potent and Sustained Reduction of Serum Lipoprotein (a) in Cynomolgus Monkeys by Aleku, Manuela, Eisermann, Mona, Löffler, Kathrin, Dames, Sibylle, Frauendorf, Christian, Wikstrom Lindholm, Marie, Schubert, Steffen, Rider, David

“…IntroductionSLN360 is a liver targeted GalNAc-conjugated siRNA developed for the treatment of cardiovascular disorders associated with elevated Lp(a). Lp(a) is…”
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