Search Results - "EISENMAN, ROBERT N."

Myc's broad reach by Eilers, Martin, Eisenman, Robert N

“…The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse…”
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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis by Carroll, Patrick A., Freie, Brian W., Mathsyaraja, Haritha, Eisenman, Robert N.

“…Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally…”
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Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis by Carroll, Patrick A., Diolaiti, Daniel, McFerrin, Lisa, Gu, Haiwei, Djukovic, Danijel, Du, Jianhai, Cheng, Pei Feng, Anderson, Sarah, Ulrich, Michelle, Hurley, James B., Raftery, Daniel, Ayer, Donald E., Eisenman, Robert N.

“…Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA,…”
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Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause by Scognamiglio, Roberta, Cabezas-Wallscheid, Nina, Thier, Marc Christian, Altamura, Sandro, Reyes, Alejandro, Prendergast, Áine M., Baumgärtner, Daniel, Carnevalli, Larissa S., Atzberger, Ann, Haas, Simon, von Paleske, Lisa, Boroviak, Thorsten, Wörsdörfer, Philipp, Essers, Marieke A.G., Kloz, Ulrich, Eisenman, Robert N., Edenhofer, Frank, Bertone, Paul, Huber, Wolfgang, van der Hoeven, Franciscus, Smith, Austin, Trumpp, Andreas

“…Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that…”
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Stress-induced cleavage of Myc promotes cancer cell survival by Conacci-Sorrell, Maralice, Ngouenet, Celine, Anderson, Sarah, Brabletz, Thomas, Eisenman, Robert N

“…Evasion of apoptosis is critical in Myc-induced tumor progression. Here we report that cancer cells evade death under stress by activating calpain-mediated…”
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Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors by Hiler, Daniel, Chen, Xiang, Hazen, Jennifer, Kupriyanov, Sergey, Carroll, Patrick A., Qu, Chunxu, Xu, Beisi, Johnson, Dianna, Griffiths, Lyra, Frase, Sharon, Rodriguez, Alberto R., Martin, Greg, Zhang, Jiakun, Jeon, Jongrye, Fan, Yiping, Finkelstein, David, Eisenman, Robert N., Baldwin, Kristin, Dyer, Michael A.

“…Cell-based therapies to treat retinal degeneration are now being tested in clinical trials. However, it is not known whether the source of stem cells is…”
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Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal by Kanatsu-Shinohara, Mito, Tanaka, Takashi, Ogonuki, Narumi, Ogura, Atsuo, Morimoto, Hiroko, Cheng, Pei Feng, Eisenman, Robert N, Trumpp, Andreas, Shinohara, Takashi

“…Myc plays critical roles in the self-renewal division of various stem cell types. In spermatogonial stem cells (SSCs), Myc controls SSC fate decisions because…”
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MAX controls meiotic entry in sexually undifferentiated germ cells by Suzuki, Ayumu, Uranishi, Kousuke, Nishimoto, Masazumi, Mizuno, Yosuke, Mizuno, Seiya, Takahashi, Satoru, Eisenman, Robert N., Okuda, Akihiko

“…Meiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor X (MAX)…”
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Essential functions of the histone demethylase lid by Li, Ling, Greer, Christina, Eisenman, Robert N, Secombe, Julie

“…Drosophila Little imaginal discs (Lid) is a recently described member of the JmjC domain class of histone demethylases that specifically targets trimethylated…”
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Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis by Diolaiti, Daniel, McFerrin, Lisa, Carroll, Patrick A., Eisenman, Robert N.

“…The transcription factor MYC and its related family members MYCN and MYCL have been implicated in the etiology of a wide spectrum of human cancers. Compared to…”
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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth by Secombe, Julie, Li, Ling, Carlos, Leni, Eisenman, Robert N

“…The Myc oncoprotein is a potent inducer of cell growth, cell cycle progression, and apoptosis. While many direct Myc target genes have been identified, the…”
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Histone Sumoylation Is Associated with Transcriptional Repression by Shiio, Yuzuru, Eisenman, Robert N.

“…Histone proteins are subject to modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, and ADP ribosylation, some of…”
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Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis by Conerly, Melissa L, Teves, Sheila S, Diolaiti, Daniel, Ulrich, Michelle, Eisenman, Robert N, Henikoff, Steven

“…The histone variant H2A.Z has been implicated in the regulation of gene expression, and in plants antagonizes DNA methylation. Here, we ask whether a similar…”
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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I by Grandori, Carla, Gomez-Roman, Natividad, Felton-Edkins, Zoe A, Ngouenet, Celine, Galloway, Denise A, Eisenman, Robert N, White, Robert J

“…c-Myc coordinates cell growth and division through a transcriptional programme that involves both RNA polymerase (Pol) II- and Pol III-transcribed genes. Here,…”
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MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation by Anderson, Sarah, Poudel, Kumud Raj, Roh-Johnson, Minna, Brabletz, Thomas, Yu, Ming, Borenstein-Auerbach, Nofit, Grady, William N., Bai, Jihong, Moens, Cecilia B., Eisenman, Robert N., Conacci-Sorrell, Maralice

“…MYC-nick is a cytoplasmic, transcriptionally inactive member of the MYC oncoprotein family, generated by a proteolytic cleavage of full-length MYC. MYC-nick…”
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Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity by Laurenti, Elisa, Varnum-Finney, Barbara, Wilson, Anne, Ferrero, Isabel, Blanco-Bose, William E, Ehninger, Armin, Knoepfler, Paul S, Cheng, Pei-Feng, MacDonald, H Robson, Eisenman, Robert N, Bernstein, Irwin D, Trumpp, Andreas

“…Myc activity is emerging as a key element in acquisition and maintenance of stem cell properties. We have previously shown that c-Myc deficiency results in…”
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The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis by Carroll, Patrick A, Freie, Brian W, Cheng, Pei Feng, Kasinathan, Sivakanthan, Gu, Haiwei, Hedrich, Theresa, Dowdle, James A, Venkataramani, Vivek, Ramani, Vijay, Wu, Xiaoying, Raftery, Daniel, Shendure, Jay, Ayer, Donald E, Muller, Charles H, Eisenman, Robert N

“…Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like…”
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Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness by Mathsyaraja, Haritha, Catchpole, Jonathen, Freie, Brian, Eastwood, Emily, Babaeva, Ekaterina, Geuenich, Michael, Cheng, Pei Feng, Ayers, Jessica, Yu, Ming, Wu, Nan, Moorthi, Sitapriya, Poudel, Kumud R, Koehne, Amanda, Grady, William, Houghton, A McGarry, Berger, Alice H, Shiio, Yuzuru, MacPherson, David, Eisenman, Robert N

“…MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive…”
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The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-Dependent c-Myc Protein Degradation by Welcker, Markus, Orian, Amir, Jin, Jianping, Grim, Jonathan A., Harper, J. Wade, Eisenman, Robert N., Clurman, Bruce E.

“…Myc proteins regulate cell growth and division and are implicated in a wide range of human cancers. We show here that Fbw7, a component of the SCFFbw7ubiquitin…”
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Metabolomics method to comprehensively analyze amino acids in different domains by Gu, Haiwei, Du, Jianhai, Carnevale Neto, Fausto, Carroll, Patrick A, Turner, Sally J, Chiorean, E Gabriela, Eisenman, Robert N, Raftery, Daniel

“…Amino acids play essential roles in both metabolism and the proteome. Many studies have profiled free amino acids (FAAs) or proteins; however, few have…”
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