Search Results - "EISENBERG, R. A"

Targeted hypermutation of putative antigen sensors in multicellular bacteria by Doré, H, Eisenberg, A R, Junkins, E N, Leventhal, G E, Ganesh, Anakha, Cordero, O X, Paul, B G, Valentine, D L, O'Malley, M A, Wilbanks, E G

“…Diversity-generating retroelements (DGRs) are used by bacteria, archaea, and viruses as a targeted mutagenesis tool. Through error-prone reverse transcription,…”
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Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease by Cohen, Philip L, Eisenberg, Robert A

“…The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the progressive accumulation of large numbers of non-malignant CD4 - CD8 -…”
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Systemic immunological effects of cytokine genes injected into skeletal muscle by EYAL RAZ, WATANABE, A, BAIRD, S. M, EISENBERG, R. A, PARR, T. B, LOTZ, M, KIPPS, T. J, CARSON, D. A

“…Somatic gene therapy is an interesting approach for the delivery of cytokines for prolonged periods. The present experiments show that direct injections into…”
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Selection of the T cell receptor repertoire in Lpr mice by Herron, LR, Eisenberg, RA, Roper, E, Kakkanaiah, VN, Cohen, PL, Kotzin, BL

“…The development of double-negative (CD4-, CD8-) T cells and other T cells subsets in lymphoproliferation (lpr) mice continues to be poorly defined. Recent…”
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An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity by SOBEL, E. S, KATAGIRI, T, KATAGIRI, K, MORRIS, S. C, COHEN, P. L, EISENBERG, R. A

“…Mice homozygous for the gene lpr develop marked lymphadenopathy and a spectrum of autoantibodies closely resembling that of human systemic lupus erythematosus…”
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Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery by Raz, E, Dudler, J, Lotz, M, Baird, S M, Berry, C C, Eisenberg, R A, Carson, D A

“…Somatic gene therapy is a novel approach with the potential to achieve prolonged increases in circulating levels of peptide hormones and cytokines. The present…”
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lpr T cells are necessary for autoantibody production in lpr mice by Sobel, ES, Cohen, PL, Eisenberg, RA

“…Mice homozygous for the gene Ipr develop a spectrum of autoantibodies closely resembling that of human SLE. Previous work has shown that the lpr defect must be…”
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V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice by Bloom, DD, Davignon, JL, Retter, MW, Shlomchik, MJ, Pisetsky, DS, Cohen, PL, Eisenberg, RA, Clarke, SH

“…Anti-Sm autoantibodies are unique to SLE, but are present in only 25% of patients with this disease. This response also occurs at a similar frequency in mice…”
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Association between anti-Sm and anti-ribosomal P protein autoantibodies in human systemic lupus erythematosus and MRL/lpr mice by Elkon, KB, Bonfa, E, Llovet, R, Eisenberg, RA

“…Anti-Sm and anti-ribosomal P protein antibodies show a high degree of specificity for the disease SLE. To determine whether a relationship between these two…”
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Diverse Antibody Recognition Patterns of the Multiple Sm-D Antigen Polypeptides by Hoch, Sallie O., Eisenberg, Robert A., Sharp, Gordon C.

“…Anti-Sm antibodies are intrinsically associated with systemic lupus erythematosus. The major targets are the so-called B and D polypeptides. The number of Sm…”
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Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein by Satoh, M, Langdon, J J, Hamilton, K J, Richards, H B, Panka, D, Eisenberg, R A, Reeves, W H

“…The Ul small nuclear ribonucleoprotein (snRNP), a complex of nine proteins with Ul RNA, is a frequent target of autoantibodies in human and murine systemic…”
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Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice by REAP, E. A, SOBEL, E. S, COHEN, P. L, EISENBERG, R. A

“…Mice homozygous for the lpr gene develop autoantibodies and polyclonal B cell activation similar to what is seen in human systemic lupus erythematosus…”
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Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice by Bloom, DD, Davignon, JL, Cohen, PL, Eisenberg, RA, Clarke, SH

“…Autoantibodies specific for the Sm ribonucleoprotein are spontaneously produced in patients with SLE and in mice of the MRL mouse strains. We have previously…”
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Autoantibodies in chronic graft versus host result from cognate T-B interactions by MORRIS, S. C, CHEEK, R. L, COHEN, P. L, EISENBERG, R. A

“…A chronic graft-versus-host reaction (GVH) induced in nonautoimmune mice causes a syndrome that closely resembles SLE. In this model, donor T cells react…”
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Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci by Bradley, DS, Jennette, JC, Cohen, PL, Eisenberg, RA

“…Murine chronic graft vs host disease (GVHD) resembles human SLE in autoantibody specificities and glomerulonephritis. Chronic GVHD is induced by donor T cell…”
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Allotype-specific immunoregulation of autoantibody production by host B cells in chronic graft-versus host disease by Morris, SC, Cheek, RL, Cohen, PL, Eisenberg, RA

“…A chronic graft-vs-host (GVH) reaction induced in nonautoimmune mice by the transfer of Ia-incompatible spleen cells results in a syndrome that closely…”
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Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells by Sekiguchi, Debora R, Eisenberg, Robert A, Weigert, Martin

“…The chronic graft-versus-host (cGVH) reaction results in a syndrome that closely resembles systemic lupus erythematosus (SLE). It is induced in nonautoimmune…”
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Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm by EISENBERG, R. A, DYER, K, CRAVEN, S. Y, FULLER, C. R, YOUNT, W. J

“…Anti-Sm antibodies are highly specific markers for the diagnosis of systemic lupus erythematosus (SLE). This specificity suggests that the immunoregulation of…”
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Development of the autoimmune B cell repertoire in MRL-lpr/lpr mice by Klinman, DM, Eisenberg, RA, Steinberg, AD

“…The processes responsible for the production of autoantibodies have been shown to include both Ag-specific and generalized (polyclonal) forms of B cell…”
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Rapid T cell receptor modulation accompanies lack of in vitro mitogenic responsiveness of double negative T cells to anti-CD3 monoclonal antibody in MRL/Mp-lpr/lpr mice by DAVIGNON, J.-L, COHEN, P. L, EISENBERG, R. A

“…The role of the CD8 super(-), CD4 super(-) (double negative) (DN) T cell accumulating in MRL/Mp-lpr/lpr) (1pr) mice is unclear. Although they bear the TCR/CD3,…”
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