Search Results - "EIGLER, Andreas"

Mature Dendritic Cells Derived from Human Monocytes Within 48 Hours: A Novel Strategy for Dendritic Cell Differentiation from Blood Precursors by Dauer, Marc, Obermaier, Bianca, Herten, Jan, Haerle, Carola, Pohl, Katrin, Rothenfusser, Simon, Schnurr, Max, Endres, Stefan, Eigler, Andreas

“…It is widely believed that generation of mature dendritic cells (DCs) with full T cell stimulatory capacity from human monocytes in vitro requires 5-7 days of…”
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The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice by Rieder, Florian, Siegmund, Britta, Bundschuh, Daniela S, Lehr, Hans-Anton, Endres, Stefan, Eigler, Andreas

“…The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of…”
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Combined use of toll-like receptor agonists and prostaglandin E2 in the FastDC model : Rapid generation of human monocyte-derived dendritic cells capable of migration and IL-12p70 production by DAUER, Marc, LAM, Veronique, ARNOLD, Hannah, JUNKMANN, Jana, KIEFL, Rosemarie, BAUER, Christian, SCHNURR, Max, ENDRES, Stefan, EIGLER, Andreas

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IFN-α promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4 by Dauer, Marc, Schad, Katharina, Junkmann, Jana, Bauer, Christian, Herten, Jan, Kiefl, Rosemarie, Schnurr, Max, Endres, Stefan, Eigler, Andreas

“…Dendritic cells (DC) generated in vitro have to be viable and phenotypically mature to be capable of inducing T cell‐mediated immunity after in vivo…”
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Specific type IV phosphodiesterase inhibitor rolipram mitigates experimental colitis in mice by Hartmann, G, Bidlingmaier, C, Siegmund, B, Albrich, S, Schulze, J, Tschoep, K, Eigler, A, Lehr, H A, Endres, S

“…The specific type IV phosphodiesterase inhibitor rolipram is a potent suppressor of tumor necrosis factor-alpha (TNF) synthesis. We examined the efficacy of…”
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Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production by Eigler, Andreas, Siegmund, Britta, Emmerich, Uta, Baumann, Klaus H., Hartmann, Gunther, Endres, Stefan

“…Interleukin‐10 (IL‐10) and tumor necrosis factor (TNF) exert key roles in some acute and chronic inflammatory diseases. In this study we investigated (1) the…”
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Adenosine kinase inhibitor GP515 improves experimental colitis in mice by Siegmund, B, Rieder, F, Albrich, S, Wolf, K, Bidlingmaier, C, Firestein, G S, Boyle, D, Lehr, H A, Loher, F, Hartmann, G, Endres, S, Eigler, A

“…Adenosine is a potent anti-inflammatory mediator. Through elevation of endogenous adenosine concentrations the adenosine kinase inhibitor GP515 might serve to…”
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Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes by Obermaier, Bianca, Dauer, Marc, Herten, Jan, Schad, Katharina, Endres, Stefan, Eigler, Andreas

“…We developed a new 2-day protocol for the generation of dendritic cells (DCs) from human monocytes in vitro. First, we demonstrated that 24 hours of culture…”
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The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice by Loher, Florian, Schmall, Kathrin, Freytag, Philipp, Landauer, Nikola, Hallwachs, Roland, Bauer, Christian, Siegmund, Britta, Rieder, Florian, Lehr, Hans-Anton, Dauer, Marc, Kapp, Joachim Friedrich, Endres, Stefan, Eigler, Andreas

“…Mesopram, a specific inhibitor of type-4 phosphodiesterase, decreases the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma…”
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Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes by Hartmann, G, Krug, A, Bidlingmaier, M, Hacker, U, Eigler, A, Albrecht, R, Strasburger, C J, Endres, S

“…Monocytes are important target cells for anti-inflammatory antisense strategies. However, monocytes are characterized by strong phagocytic and catalytic…”
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Technical success, resection status, and procedural complication rate of colonoscopic full-wall resection: a pooled analysis from 7 hospitals of different care levels by Krutzenbichler, Irmengard, Dollhopf, Markus, Diepolder, Helmut, Eigler, Andreas, Fuchs, Martin, Herrmann, Simon, Kleber, Gerhard, Lewerenz, Björn, Kaiser, Christoph, Lilje, Tilman, Rath, Timo, Agha, Ayman, Vitali, Francesco, Schäfer, Claus, Schepp, Wolfgang, Gundling, Felix

“…Introduction Endoscopic full-thickness resection (eFTR) using the full-thickness resection device (FTRD®) is a novel minimally invasive procedure that allows…”
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Suppression of TNF-α production in human mononuclear cells by an adenosine kinase inhibitor by Eigler, Andreas, Matschke, Verena, Hartmann, Gunther, Erhardt, Simon, Boyle, David, Firestein, Gary S., Endres, Stefan

“…Adenosine exerts potent anti‐inflammatory activities through inhibition of cytokine synthesis by activated monocytes. Adenosine is rapidly phosphorylated…”
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Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8+ T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model by Bauer, Christian, Sterzik, Alexander, Bauernfeind, Franz, Duewell, Peter, Conrad, Claudius, Kiefl, Rosemarie, Endres, Stefan, Eigler, Andreas, Schnurr, Max, Dauer, Marc

“…Background Multiple studies have shown that dendritic cell (DC)-based vaccines can induce antitumor immunity. Previously, we reported that gemcitabine enhances…”
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ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells by Duewell, Peter, Kisser, Ulrich, Heckelsmiller, Klaus, Hoves, Sabine, Stoitzner, Patrizia, Koernig, Sandra, Morelli, Adriana B, Clausen, Björn E, Dauer, Marc, Eigler, Andreas, Anz, David, Bourquin, Carole, Maraskovsky, Eugene, Endres, Stefan, Schnurr, Max

“…Cancer vaccines aim to induce CTL responses against tumors. Challenges for vaccine design are targeting Ag to dendritic cells (DCs) in vivo, facilitating…”
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An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma by Jacobs, Collin, Duewell, Peter, Heckelsmiller, Klaus, Wei, Jiwu, Bauernfeind, Franz, Ellermeier, Jonathan, Kisser, Ulrich, Bauer, Christian A., Dauer, Marc, Eigler, Andreas, Maraskovsky, Eugene, Endres, Stefan, Schnurr, Max

“…Vaccines based on immune stimulatory complexes (ISCOM) induce T‐cell responses against tumor antigen (Ag). However, immune responses are impaired in pancreatic…”
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Meningeal spread of blastic plasmacytoid dendritic cell neoplasm by Starck, Michael, Zewen, Stefan, Eigler, Andreas, Wendtner, Clemens-Martin

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Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and γδ T cells by SCHNURR, Max, SCHOLZ, Christoph, ROTHENFUSSER, Simon, GALAMBOS, Peter, DAUER, Marc, RÖBE, Julian, ENDRES, Stefan, EIGLER, Andreas

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Dendritic cell-based vaccination of patients with advanced pancreatic carcinoma: results of a pilot study by Bauer, Christian, Dauer, Marc, Saraj, Samira, Schnurr, Maximilian, Bauernfeind, Franz, Sterzik, Alexander, Junkmann, Jana, Jakl, Veronika, Kiefl, Rosemarie, Oduncu, Fuat, Emmerich, Bertold, Mayr, Doris, Mussack, Thomas, Bruns, Christiane, Rüttinger, Dominik, Conrad, Claudius, Jauch, Karl-Walter, Endres, Stefan, Eigler, Andreas

“…Background and aims Dendritic cell (DC)-based vaccination can induce antitumor T cell responses in vivo. This clinical pilot study examined feasibility and…”
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The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-α mRNA expression by BAUER, Christian, LOHER, Florian, DAUER, Marc, MAYER, Christine, LEHR, Hans Anton, SCHÖNHARTING, Martin, HALLWACHS, Roland, ENDRES, Stefan, EIGLER, Andreas

“…Previously we demonstrated an ameliorating effect of the interleukin-1beta converting enzyme (ICE) inhibitor pralnacasan on dextran sulfate sodium…”
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Tumor cell lysate-pulsed human dendritic cells induce a t-cell response against pancreatic carcinoma cells : An in vitro model for the assessment of tumor vaccines by SCHNURR, Max, GALAMBOS, Peter, SCHOLZ, Christoph, THEN, Florian, DAUER, Marc, ENDRES, Stefan, EIGLER, Andreas

“…Dendritic cells (DCs) are potent antigen-presenting cells and play a pivotal role in T cell-mediated immunity. DCs have been shown to induce strong antitumor…”
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