Search Results - "EICKHOFF, Jan"

Modulators of 14-3‑3 Protein–Protein Interactions by Stevers, Loes M, Sijbesma, Eline, Botta, Maurizio, MacKintosh, Carol, Obsil, Tomas, Landrieu, Isabelle, Cau, Ylenia, Wilson, Andrew J, Karawajczyk, Anna, Eickhoff, Jan, Davis, Jeremy, Hann, Michael, O’Mahony, Gavin, Doveston, Richard G, Brunsveld, Luc, Ottmann, Christian

“…Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of…”
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A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling by Brüggenthies, Johanna B., Fiore, Alessandra, Russier, Marion, Bitsina, Christina, Brötzmann, Julian, Kordes, Susanne, Menninger, Sascha, Wolf, Alexander, Conti, Elena, Eickhoff, Jan E., Murray, Peter J.

“…mTORC1 and GCN2 are serine/threonine kinases that control how cells adapt to amino acid availability. mTORC1 responds to amino acids to promote translation and…”
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A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations by Hutterer, Corina, Eickhoff, Jan, Milbradt, Jens, Korn, Klaus, Zeitträger, Isabel, Bahsi, Hanife, Wagner, Sabrina, Zischinsky, Gunther, Wolf, Alexander, Degenhart, Carsten, Unger, Anke, Baumann, Matthias, Klebl, Bert, Marschall, Manfred

“…Protein kinases represent central and multifunctional regulators of a balanced virus-host interaction. Cyclin-dependent protein kinase 7 (CDK7) plays crucial…”
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Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer by Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael

“…Selective inhibition of exclusively transcription‐regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY‐958,…”
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Stabilization of protein-protein interactions in drug discovery by Andrei, Sebastian A, Sijbesma, Eline, Hann, Michael, Davis, Jeremy, O'Mahony, Gavin, Perry, Matthew W D, Karawajczyk, Anna, Eickhoff, Jan, Brunsveld, Luc, Doveston, Richard G, Milroy, Lech-Gustav, Ottmann, Christian

“…PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects of developing…”
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Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency by Schütz, Martin, Wangen, Christina, Sommerer, Mona, Kögler, Melanie, Eickhoff, Jan, Degenhart, Carsten, Klebl, Bert, Naing, Zin, Egilmezer, Ece, Hamilton, Stuart T., Rawlinson, William D., Sticht, Heinrich, Marschall, Manfred

“…• Consistent upregulation of cyclin H in various human cell types by strains of HCMV. • Reduced or increased vCDK/pUL97 kinase activity as a consequence of…”
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Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells by Kelso, Timothy W. R., Baumgart, Karen, Eickhoff, Jan, Albert, Thomas, Antrecht, Claudia, Lemcke, Sarah, Klebl, Bert, Meisterernst, Michael

“…Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Although there is substantial evidence…”
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Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs) by Wild, Markus, Kicuntod, Jintawee, Seyler, Lisa, Wangen, Christina, Bertzbach, Luca D, Conradie, Andelé M, Kaufer, Benedikt B, Wagner, Sabrina, Michel, Detlef, Eickhoff, Jan, Tsogoeva, Svetlana B, Bäuerle, Tobias, Hahn, Friedrich, Marschall, Manfred

“…Human cytomegalovirus (HCMV) is a human pathogenic herpesvirus associated with a variety of clinical symptoms. Current antiviral therapy is not always…”
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Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers by Wild, Markus, Karner, Dubravka, Eickhoff, Jan, Wagner, Sabrina, Kicuntod, Jintawee, Chang, William, Barry, Peter, Jonjić, Stipan, Lenac Roviš, Tihana, Marschall, Manfred

“…Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes…”
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Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ by Andlovic, Blaž, Wolf, Alexander, Hiltmann, Malgorzata, Klebl, Bert M., Eickhoff, Jan, Ottmann, Christian

“…The Hippo pathway plays an important role in organ size control and tissue homeostasis. Dysregulation is involved in many pathologies, including cancer, which…”
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Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo by Reinhardt, Lydia, Kordes, Susanne, Reinhardt, Peter, Glatza, Michael, Baumann, Matthias, Drexler, Hannes C.A., Menninger, Sascha, Zischinsky, Gunther, Eickhoff, Jan, Fröb, Claudia, Bhattarai, Prabesh, Arulmozhivarman, Guruchandar, Marrone, Lara, Janosch, Antje, Adachi, Kenjiro, Stehling, Martin, Anderson, Eric N., Abo-Rady, Masin, Bickle, Marc, Pandey, Udai Bhan, Reimer, Michell M., Kizil, Caghan, Schöler, Hans R., Nussbaumer, Peter, Klebl, Bert, Sterneckert, Jared L.

“…Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem…”
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An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity by Yu, DongHoon, Wagner, Sabrina, Schütz, Martin, Jeon, Yeejin, Seo, Mooyoung, Kim, Jaeseung, Brückner, Nadine, Kicuntod, Jintawee, Tillmanns, Julia, Wangen, Christina, Hahn, Friedrich, Kaufer, Benedikt B, Neipel, Frank, Eickhoff, Jan, Klebl, Bert, Nam, Kiyean, Marschall, Manfred

“…The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These…”
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Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target by Tillmanns, Julia, Häge, Sigrun, Borst, Eva Maria, Wardin, Julia, Eickhoff, Jan, Klebl, Bert, Wagner, Sabrina, Wangen, Christina, Hahn, Friedrich, Socher, Eileen, Marschall, Manfred

“…Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear…”
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Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate by Sagurna, Leonie, Heinrich, Sascha, Kaufmann, Lara-Sophie, Rückert-Reed, Christian, Busche, Tobias, Wolf, Alexander, Eickhoff, Jan, Klebl, Bert, Kalinowski, Jörn, Bandow, Julia E

“…Bacteria of the genus produce various specialized metabolites. Single biosynthetic gene clusters (BGCs) can give rise to different products that can vary in…”
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Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1 by FEICHTINGER, Sabine, STAMMINGER, Thomas, MÜLLER, Regina, GRAF, Laura, KLEBL, Bert, EICKHOFF, Jan, MARSCHALL, Manfred

“…Cyclin-dependent protein kinases (CDKs) are important regulators of cellular processes and are functionally integrated into the replication of human…”
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ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis by Cibir, Zülal, Hassel, Jacqueline, Sonneck, Justin, Kowitz, Lennart, Beer, Alexander, Kraus, Andreas, Hallekamp, Gabriel, Rosenkranz, Martin, Raffelberg, Pascal, Olfen, Sven, Smilowski, Kamil, Burkard, Roman, Helfrich, Iris, Tuz, Ali Ata, Singh, Vikramjeet, Ghosh, Susmita, Sickmann, Albert, Klebl, Anne-Kathrin, Eickhoff, Jan Eike, Klebl, Bert, Seidl, Karsten, Chen, Jianxu, Grabmaier, Anton, Viga, Reinhard, Gunzer, Matthias

“…Autonomous migration is essential for the function of immune cells such as neutrophils and plays an important role in numerous diseases. The ability to…”
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Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity by Rechter, Sabine, Scott, Gillian M., Eickhoff, Jan, Zielke, Katrin, Auerochs, Sabrina, Müller, Regina, Stamminger, Thomas, Rawlinson, William D., Marschall, Manfred

“…Replication of human cytomegalovirus (HCMV) is subject to regulation by cellular protein kinases. Recently, we and others reported that inhibition of…”
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Proteomic characterization of the angiogenesis inhibitor SU6668 reveals multiple impacts on cellular kinase signaling by GODL, Klaus, GRUSS, Oliver J, KERI, György, MÜLLER, Stefan, COTTON, Matt, ULLRICH, Axel, DAUB, Henrik, EICKHOFF, Jan, WISSING, Josef, BLENCKE, Stephanie, WEBER, Martina, DEGEN, Heidrun, BREHMER, Dirk, ÖRFI, Laszlo, HORVATH, Zoltan

“…Knowledge about molecular drug action is critical for the development of protein kinase inhibitors for cancer therapy. Here, we establish a chemical proteomic…”
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The Role of RIP2 in p38 MAPK Activation in the Stressed Heart by Jacquet, Sebastien, Nishino, Yasuhiro, Kumphune, Sarawut, Sicard, Pierre, Clark, James E., Kobayashi, Koichi S., Flavell, Richard A., Eickhoff, Jan, Cotten, Matt, Marber, Michael S.

“…The activation of p38 MAPK by dual phosphorylation aggravates myocardial ischemic injury and depresses cardiac contractile function. SB203580, an…”
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A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening by Kaufmann, Johanna, Blum, Nina Kathleen, Nagel, Falko, Schuler, Anna, Drube, Julia, Degenhart, Carsten, Engel, Julian, Eickhoff, Jan Eicke, Dasgupta, Pooja, Fritzwanker, Sebastian, Guastadisegni, Maria, Schulte, Clemens, Miess-Tanneberg, Elke, Maric, Hans Michael, Spetea, Mariana, Kliewer, Andrea, Baumann, Matthias, Klebl, Bert, Reinscheid, Rainer K., Hoffmann, Carsten, Schulz, Stefan

“…Analysis of agonist-driven phosphorylation of G protein-coupled receptors (GPCRs) can provide valuable insights into the receptor activation state and ligand…”
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