Search Results - "EHRICH, Mathias"

Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants by Lefkowitz, Roy B., PhD, Tynan, John A., PhD, Liu, Tong, PhD, Wu, Yijin, PhD, Mazloom, Amin R., PhD, Almasri, Eyad, MS, Hogg, Grant, MS, Angkachatchai, Vach, PhD, Zhao, Chen, PhD, Grosu, Daniel S., MD, McLennan, Graham, MS, Ehrich, Mathias, MD

“…Background Current cell-free DNA assessment of fetal chromosomes does not analyze and report on all chromosomes. Hence, a significant proportion of fetal…”
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Noninvasive prenatal screening for fetal trisomies 21, 18, 13 and the common sex chromosome aneuploidies from maternal blood using massively parallel genomic sequencing of DNA by Porreco, Richard P., MD, Garite, Thomas J., MD, Maurel, Kimberly, MSN, CNS, Marusiak, Barbara, MS, CRM, Ehrich, Mathias, MD, van den Boom, Dirk, PhD, Deciu, Cosmin, MS, Bombard, Allan, MD

“…Objective The objective of this study was to validate the clinical performance of massively parallel genomic sequencing of cell-free deoxyribonucleic acid…”
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Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting by Ehrich, Mathias, MD, Deciu, Cosmin, MSc, Zwiefelhofer, Tricia, Tynan, John A., DPhil, Cagasan, Lesley, MSc, Tim, Roger, DPhil, Lu, Vivian, McCullough, Ron, DPhil, McCarthy, Erin, Nygren, Anders O.H., DPhil, Dean, Jarrod, Tang, Lin, DPhil, Hutchison, Don, MSc, Lu, Tim, DPhil, Wang, Huiquan, DPhil, Angkachatchai, Vach, DPhil, Oeth, Paul, MSc, Cantor, Charles R., DPhil, Bombard, Allan, MD, van den Boom, Dirk, DPhil

“…Objective We sought to evaluate a multiplexed massively parallel shotgun sequencing assay for noninvasive trisomy 21 detection using circulating cell-free…”
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Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma by Zhao, Chen, Tynan, John, Ehrich, Mathias, Hannum, Gregory, McCullough, Ron, Saldivar, Juan-Sebastian, Oeth, Paul, van den Boom, Dirk, Deciu, Cosmin

“…The development of sequencing-based noninvasive prenatal testing (NIPT) has been largely focused on whole-chromosome aneuploidies (chromosomes 13, 18, 21, X,…”
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Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts by Kim, Sung K., Hannum, Gregory, Geis, Jennifer, Tynan, John, Hogg, Grant, Zhao, Chen, Jensen, Taylor J., Mazloom, Amin R., Oeth, Paul, Ehrich, Mathias, van den Boom, Dirk, Deciu, Cosmin

“…Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the…”
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DNA sequencing of maternal plasma to detect Down syndrome: An international clinical validation study by Palomaki, Glenn E, Kloza, Edward M, Lambert-Messerlian, Geralyn M, Haddow, James E, Neveux, Louis M, Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T, Deciu, Cosmin, Grody, Wayne W, Nelson, Stanley F, Canick, Jacob A

“…Purpose: Prenatal screening for Down syndrome has improved, but the number of resulting invasive diagnostic procedures remains problematic. Measurement of…”
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Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing by Dharajiya, Nilesh G, Grosu, Daniel S, Farkas, Daniel H, McCullough, Ron M, Almasri, Eyad, Sun, Youting, Kim, Sung K, Jensen, Taylor J, Saldivar, Juan-Sebastian, Topol, Eric J, van den Boom, Dirk, Ehrich, Mathias

“…Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal…”
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Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing by Wong, David, Moturi, Sharmili, Angkachatchai, Vach, Mueller, Reinhold, DeSantis, Grace, van den Boom, Dirk, Ehrich, Mathias

“…Fetal mutations and fetal chromosomal abnormalities can be detected by molecular analysis of circulating cell free fetal DNA (ccffDNA) from maternal plasma…”
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Detection of Microdeletion 22q11.2 in a Fetus by Next-Generation Sequencing of Maternal Plasma by JENSEN, Taylor J, DZAKULA, Zeljko, DECIU, Cosmin, VAN DEN BOOM, Dirk, EHRICH, Mathias

“…Efforts have been undertaken recently to assess the fetal genome through analysis of circulating cell-free (ccf) fetal DNA obtained from maternal plasma…”
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DNA sequencing of maternal plasma reliably identifies trisomy 18 and trisomy 13 as well as Down syndrome: an international collaborative study by Palomaki, Glenn E., Deciu, Cosmin, Kloza, Edward M., Lambert-Messerlian, Geralyn M., Haddow, James E., Neveux, Louis M., Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T., Grody, Wayne W., Nelson, Stanley F., Canick, Jacob A.

“…Purpose: To determine whether maternal plasma cell–free DNA sequencing can effectively identify trisomy 18 and 13. Methods: Sixty-two pregnancies with trisomy…”
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Oct4-Induced Pluripotency in Adult Neural Stem Cells by Kim, Jeong Beom, Sebastiano, Vittorio, Wu, Guangming, Araúzo-Bravo, Marcos J., Sasse, Philipp, Gentile, Luca, Ko, Kinarm, Ruau, David, Ehrich, Mathias, van den Boom, Dirk, Meyer, Johann, Hübner, Karin, Bernemann, Christof, Ortmeier, Claudia, Zenke, Martin, Fleischmann, Bernd K., Zaehres, Holm, Schöler, Hans R.

“…The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse and human fibroblasts. We previously described direct reprogramming…”
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Quantitative High-Throughput Analysis of DNA Methylation Patterns by Base-Specific Cleavage and Mass Spectrometry by Mathias Ehrich, Nelson, Matthew R., Stanssens, Patrick, Zabeau, Marc, Triantafillos Liloglou, George Xinarianos, Cantor, Charles R., John K. Field, van den Boom, Dirk

“…Methylation is one of the major epigenetic processes pivotal to our understanding of carcinogenesis. It is now widely accepted that there is a relationship…”
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Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma by Mazloom, Amin R., Džakula, Željko, Oeth, Paul, Wang, Huiquan, Jensen, Taylor, Tynan, John, McCullough, Ron, Saldivar, Juan-Sebastian, Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T., Maeder, Margo, McLennan, Graham, Meschino, Wendy, Palomaki, Glenn E., Canick, Jacob A., Deciu, Cosmin

“…ABSTRACT Objective Whole‐genome sequencing of circulating cell free (ccf) DNA from maternal plasma has enabled noninvasive prenatal testing for common…”
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DNA sequencing of maternal plasma to identify Down syndrome and other trisomies in multiple gestations by Canick, Jacob A., Kloza, Edward M., Lambert-Messerlian, Geralyn M., Haddow, James E., Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T., Deciu, Cosmin, Palomaki, Glenn E.

“…ABSTRACT Objective Studies on prenatal testing for Down syndrome (trisomy 21), trisomy 18, and trisomy 13 by massively parallel shotgun sequencing (MPSS) of…”
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Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing by Linhart, Heinz G, Lin, Haijiang, Yamada, Yasuhiro, Moran, Eva, Steine, Eveline J, Gokhale, Sumita, Lo, Grace, Cantu, Erika, Ehrich, Mathias, He, Timothy, Meissner, Alex, Jaenisch, Rudolf

“…Increased methylation of CpG islands and silencing of affected target genes is frequently found in human cancer; however, in vivo the question of causality has…”
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Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice by Kansara, Maya, Tsang, Michael, Kodjabachian, Laurent, Sims, Natalie A, Trivett, Melanie K, Ehrich, Mathias, Dobrovic, Alexander, Slavin, John, Choong, Peter F M, Simmons, Paul J, Dawid, Igor B, Thomas, David M

“…Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies…”
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Quantitative DNA methylation predicts survival in adult acute myeloid leukemia by Bullinger, Lars, Ehrich, Mathias, Döhner, Konstanze, Schlenk, Richard F., Döhner, Hartmut, Nelson, Matthew R., van den Boom, Dirk

“…Acute myeloid leukemia (AML) is characterized by molecular heterogeneity that is not fully reflected in the current classification system. Recent insights…”
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Quantification of Fetal DNA by Use of Methylation-Based DNA Discrimination by NYGREN, Anders O. H, DEAN, Jarrod, JENSEN, Taylor J, KRUSE, Selena, KWONG, William, VAN DEN BOOM, Dirk, EHRICH, Mathias

“…Detection of circulating cell-free fetal nucleic acids in maternal plasma has been used in noninvasive prenatal diagnostics. Most applications rely on the…”
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Cytosine methylation profiling of cancer cell lines by Ehrich, Mathias, Turner, Julia, Gibbs, Peter, Lipton, Lara, Giovanneti, Mara, Cantor, Charles, van den Boom, Dirk

“…DNA-methylation changes in human cancer are complex and vary between the different types of cancer. Capturing this epigenetic variability in an atlas of…”
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High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma by Jensen, Taylor J, Zwiefelhofer, Tricia, Tim, Roger C, Džakula, Željko, Kim, Sung K, Mazloom, Amin R, Zhu, Zhanyang, Tynan, John, Lu, Tim, McLennan, Graham, Palomaki, Glenn E, Canick, Jacob A, Oeth, Paul, Deciu, Cosmin, van den Boom, Dirk, Ehrich, Mathias

“…Circulating cell-free (ccf) fetal DNA comprises 3-20% of all the cell-free DNA present in maternal plasma. Numerous research and clinical studies have…”
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