Search Results - "EHLERT, F. J"

Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle by Li, M, Bullock, C M, Knauer, D J, Ehlert, F J, Zhou, Q Y

“…The motility of gastrointestinal tract is regulated by classical neurotransmitters, neuropeptides, and humoral agents. Two novel human cDNAs have been cloned…”
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Investigating the interaction of McN‐A‐343 with the M1 muscarinic receptor using its nitrogen mustard derivative and ACh mustard by Figueroa, KW, Suga, H, Ehlert, FJ

“…Background and purpose:  We investigated how McN‐A‐343 inhibited the alkylation of the M1 muscarinic receptor by its nitrogen mustard derivative and that of…”
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Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods by Ehlert, F J

“…The theoretical basis for using radioligand binding and pharmacological techniques to estimate the dissociation constants of drugs which interact…”
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The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition in the rabbit myocardium by Ehlert, F J

“…The muscarinic receptor-binding properties of a series of muscarinic drugs were compared with their effects on adenylate cyclase in membranes of the rabbit…”
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Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum by Thomas, E A, Baker, S A, Ehlert, F J

“…A functional role for the M2 muscarinic receptor in smooth muscle contraction was investigated in isolated guinea pig ileum. Contractile responses to the…”
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Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain by Ehlert, F J, Tran, L P

“…The distribution of subtypes of the muscarinic receptor in homogenates of the rat brain was investigated by measuring the competitive inhibition of the binding…”
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Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis by Thomas, E A, Ehlert, F J

“…The effects of pertussis toxin on muscarinic receptor-induced contractions of the isolated guinea pig ileum were investigated. In control tissues,…”
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Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain by BURKEY, T. H, QUOCK, R. M, CONSROE, P, EHLERT, F. J, HOSOHATA, Y, ROESKE, W. R, YAMAMURA, H. I

“…We measured (-)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohe xyl]-phenol (CP 55,940)-, (-)11-OH-delta8-tetrahydrocannabinol-dimethylheptyl…”
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The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder by Pak, K J, Ostrom, R S, Matsui, M, Ehlert, F J

“…We investigate the role of M(2)-muscarinic receptors in maintaining neurogenic bladder contraction during hyperglycemia. Mice were injected with a single dose…”
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Specific inhibition of isoproterenol-stimulated cyclic AMP accumulation by M2 muscarinic receptors in rat intestinal smooth muscle by Griffin, M T, Ehlert, F J

“…The ability of oxotremorine-M to inhibit cyclic AMP accumulation in the presence of a variety of adenylate cyclase activators was studied in slices from the…”
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Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium by Ehlert, F J

“…The ability of gallamine to modify muscarinic receptor binding properties and to antagonize muscarinic receptor-mediated inhibition of adenylate cyclase…”
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Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum by Candell, L M, Yun, S H, Tran, L L, Ehlert, F J

“…The binding affinities of selective muscarinic antagonists were compared with their ability to block receptor-mediated inhibition of adenylate cyclase and…”
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Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder by Pak, K. J., Ostrom, R. S., Matsui, M., Ehlert, F. J.

“…We investigated the contractile roles of M 2 and M 3 muscarinic receptors in urinary bladder from streptozotocin-treated mice. Wild-type and M 2 muscarinic…”
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Investigating the interaction of McN‐A‐343 with the M 1 muscarinic receptor using its nitrogen mustard derivative and ACh mustard by Figueroa, KW, Suga, H, Ehlert, FJ

“…Background and purpose:  We investigated how McN‐A‐343 inhibited the alkylation of the M 1 muscarinic receptor by its nitrogen mustard derivative and that of…”
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Heterogeneity of muscarinic receptor subtypes in cerebral blood vessels by Garcia-Villalon, A L, Krause, D N, Ehlert, F J, Duckles, S P

“…The identity and distribution of muscarinic cholinergic receptor subtypes and associated signal transduction mechanisms was characterized for the cerebral…”
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Coupling of muscarinic receptors to adenylate cyclase in the rabbit myocardium: effects of receptor inactivation by Ehlert, F J

“…The relationship between muscarinic receptor occupancy and adenylate cyclase inhibition was investigated in homogenates of the rabbit myocardium. The highly…”
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Heparin, dextran and trypan blue allosterically modulate M2 muscarinic receptor binding properties and interfere with receptor-mediated inhibition of adenylate cyclase by Gerstin, Jr, E H, Luong, T, Ehlert, F J

“…The influences of heparin, dextran and trypan blue on muscarinic receptor binding properties and inhibition of adenylate cyclase were investigated in…”
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The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor by Ehlert, F J, Griffin, M T, Glidden, P F

“…The pharmacological activity of the enantiomers of aceclidine was investigated in Chinese hamster ovary cells transfected with the M1 through M5 subtypes of…”
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Coupling of subtypes of the muscarinic receptor to adenylate cyclase in the corpus striatum and heart by Ehlert, F J, Delen, F M, Yun, S H, Friedman, D J, Self, D W

“…The binding properties of a series of muscarinic antagonists were compared with their ability to antagonize muscarinic receptor mediated inhibition of…”
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Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues by Thomas, E A, Hsu, H H, Griffin, M T, Hunter, A L, Luong, T, Ehlert, F J

“…A 2-chloroethylamine derivative [N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard)] of the selective muscarinic antagonist…”
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