Search Results - "EHLERS, Stefan"

DC-SIGN and mannosylated surface structures of Mycobacterium tuberculosis: a deceptive liaison by Ehlers, Stefan

“…Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is recognized by pattern recognition receptors on macrophages and dendritic cells,…”
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Tumor Necrosis Factor and Its Blockade in Granulomatous Infections: Differential Modes of Action of Infliximab and Etanercept? by Ehlers, Stefan

“…Tumor necrosis factor (TNF) is a critical component of both the antibacterially protective and the inflammatory responses against infections, particularly…”
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The granuloma in tuberculosis: dynamics of a host-pathogen collusion by Ehlers, Stefan, Schaible, Ulrich E

“…A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a…”
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Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses by Schaale, Kolja, Neumann, Jan, Schneider, Dagmar, Ehlers, Stefan, Reiling, Norbert

“…Wnt proteins are secreted, palmitoylated glycoproteins with multiple functions in cell proliferation and migration as well as tissue organization. They are…”
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Common patterns and disease-related signatures in tuberculosis and sarcoidosis by Maertzdorf, Jeroen, Weiner, January, Mollenkopf, Hans-Joachim, Bauer, Torsten, Prasse, Antje, Müller-Quernheim, Joachim, Kaufmann, Stefan H. E.

“…In light of the marked global health impact of tuberculosis (TB), strong focus has been on identifying biosignatures. Gene expression profiles in blood cells…”
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The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation by Blumenthal, Antje, Ehlers, Stefan, Lauber, Jörg, Buer, Jan, Lange, Christoph, Goldmann, Torsten, Heine, Holger, Brandt, Ernst, Reiling, Norbert

“…Microarray - assisted gene - expression screens of human macrophages revealed WNT5A, a homolog of Wingless, a key regulator of Drosophila melanogaster…”
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Clade-specific virulence patterns of Mycobacterium tuberculosis complex strains in human primary macrophages and aerogenically infected mice by Reiling, Norbert, Homolka, Susanne, Walter, Kerstin, Brandenburg, Julius, Niwinski, Lisa, Ernst, Martin, Herzmann, Christian, Lange, Christoph, Diel, Roland, Ehlers, Stefan, Niemann, Stefan

“…In infection experiments with genetically distinct Mycobacterium tuberculosis complex (MTBC) strains, we identified clade-specific virulence patterns in human…”
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Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910 by LENAERTS, Anne J, HOFF, Donald, ALY, Sahar, EHLERS, Stefan, ANDRIES, Koen, CANTARERO, Luis, ORME, Ian M, BASARABA, Randall J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection by Behrends, Jochen, Renauld, Jean-Christophe, Ehlers, Stefan, Hölscher, Christoph

“…Anti-inflammatory treatment of autoimmune diseases is associated with an increased risk of reactivation tuberculosis (TB). Besides interleukin (IL-17)A, IL-22…”
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Infection, inflammation, and chronic diseases: consequences of a modern lifestyle by Ehlers, Stefan, Kaufmann, Stefan H.E

“…Infectious diseases, including tuberculosis, malaria, hepatitis, pneumonia, dysentery, and helminth infestations, still constitute a profound threat in…”
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Mycobacterium tuberculosis embB Codon 306 Mutations Confer Moderately Increased Resistance to Ethambutol In Vitro and In Vivo by PLINKE, Claudia, WALTER, Kerstin, ALY, Sahar, EHLERS, Stefan, NIEMANN, Stefan

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The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GlnR in nitrate assimilation of Mycobacterium tuberculosis by Malm, Sven, Tiffert, Yvonne, Micklinghoff, Julia, Schultze, Sonja, Joost, Insa, Weber, Isabel, Horst, Sarah, Ackermann, Birgit, Schmidt, Mascha, Wohlleben, Wolfgang, Ehlers, Stefan, Geffers, Robert, Reuther, Jens, Bange, Franz-Christoph

“…1 Department of Medical Microbiology and Hospital Epidemiology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany 2…”
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The IL-27 Receptor Chain WSX-1 Differentially Regulates Antibacterial Immunity and Survival during Experimental Tuberculosis by Holscher, Christoph, Holscher, Alexandra, Ruckerl, Dominik, Yoshimoto, Takayuki, Yoshida, Hiroki, Mak, Tak, Saris, Christiaan, Ehlers, Stefan

“…IL-12 is a potent inducer of IFN-gamma production and promotes a protective cell-mediated immune response after Mycobacterium tuberculosis infection. Recently,…”
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Genetically Determined Susceptibility to Tuberculosis in Mice Causally Involves Accelerated and Enhanced Recruitment of Granulocytes by Keller, Christine, Hoffmann, Reinhard, Lang, Roland, Brandau, Sven, Hermann, Corinna, Ehlers, Stefan

“…Classical twin studies and recent linkage analyses of African populations have revealed a potential involvement of host genetic factors in susceptibility or…”
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Inflammatory Macrophages Induce Nrf2 Transcription Factor-dependent Proteasome Activity in Colonic NCM460 Cells and Thereby Confer Anti-apoptotic Protection by Sebens, Susanne, Bauer, Iris, Geismann, Claudia, Grage-Griebenow, Evelin, Ehlers, Stefan, Kruse, Marie-Luise, Arlt, Alexander, Schäfer, Heiner

“…Adaptation of epithelial cells to persistent oxidative stress plays an important role in inflammation-associated carcinogenesis. This adaptation process…”
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Tumor necrosis factor and granuloma biology: Explaining the differential infection risk of etanercept and infliximab by Wallis, Robert S., Ehlers, Stefan

“…Several studies show that the risk of granulomatous infections following therapy with the anti-tumor necrosis factor (TNF) antibody infliximab is higher than…”
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Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis by Thye, Thorsten, Niemann, Stefan, Walter, Kerstin, Homolka, Susanne, Intemann, Christopher D, Chinbuah, Margaret Amanua, Enimil, Anthony, Gyapong, John, Osei, Ivy, Owusu-Dabo, Ellis, Rüsch-Gerdes, Sabine, Horstmann, Rolf D, Ehlers, Stefan, Meyer, Christian G

“…Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns…”
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Towards a comprehensive view of the bacterial cell wall by Dmitriev, Boris, Toukach, Filip, Ehlers, Stefan

“…Direct in vivo visualization, in full atomic detail, of the microbial cell wall and its stress-bearing structural architecture remains one of the prime…”
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Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis by Schmok, Erik, Abad Dar, Mahin, Behrends, Jochen, Erdmann, Hanna, Rückerl, Dominik, Endermann, Tanja, Heitmann, Lisa, Hessmann, Manuela, Yoshimura, Akihiko, Rose-John, Stefan, Scheller, Jürgen, Schaible, Ulrich Emil, Ehlers, Stefan, Lang, Roland, Hölscher, Christoph

“…Suppressor of cytokine signaling 3 (SOCS3) is a feedback inhibitor of interleukin (IL)-6 signaling in macrophages. In the absence of this molecule, macrophages…”
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MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis by Reiling, Norbert, Ehlers, Stefan, Hölscher, Christoph

“…Abstract Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like…”
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