Search Results - "EGGELING, Lothar"

A giant market and a powerful metabolism: l-lysine provided by Corynebacterium glutamicum by Eggeling, Lothar, Bott, Michael

“…l -lysine is made in an exceptional large quantity of currently 2,200,000 tons/year and belongs therefore to one of the leading biotechnological products…”
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Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors by Batt, Sarah M, Jabeen, Talat, Bhowruth, Veemal, Quill, Lee, Lund, Peter A, Eggeling, Lothar, Alderwick, Luke J, Fütterer, Klaus, Besra, Gurdyal S

“…Resistance against currently used antitubercular therapeutics increasingly undermines efforts to contain the worldwide tuberculosis (TB) epidemic. Recently,…”
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Pushing product formation to its limit: Metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction by Vogt, Michael, Haas, Sabine, Klaffl, Simon, Polen, Tino, Eggeling, Lothar, van Ooyen, Jan, Bott, Michael

“…Using metabolic engineering, an efficient l-leucine production strain of Corynebacterium glutamicum was developed. In the wild type of C. glutamicum, the…”
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A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level by Grünberger, Alexander, Paczia, Nicole, Probst, Christopher, Schendzielorz, Georg, Eggeling, Lothar, Noack, Stephan, Wiechert, Wolfgang, Kohlheyer, Dietrich

“…In the continuously growing field of industrial biotechnology the scale-up from lab to industrial scale is still a major hurdle to develop competitive…”
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Metabolic Function of Corynebacterium glutamicum Aminotransferases AlaT and AvtA and Impact on l-Valine Production by MARIENHAGEN, Jan, EGGELING, Lothar

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high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level by Binder, Stephan, Schendzielorz, Georg, Stäbler, Norma, Krumbach, Karin, Hoffmann, Kristina, Bott, Michael, Eggeling, Lothar

“…We present a novel method for visualizing intracellular metabolite concentrations within single cells of Escherichia coli and Corynebacterium glutamicum that…”
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Corynebacterium glutamicum as a Host for Synthesis and Export of d-Amino Acids by Stäbler, Norma, Oikawa, Tadao, Bott, Michael, Eggeling, Lothar

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Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs by Tatituri, Raju V. V., Watts, Gerald F. M., Bhowruth, Veemal, Barton, Nathaniel, Rothchild, Alissa, Hsu, Fong-Fu, Almeida, Catarina F., Cox, Liam R., Eggeling, Lothar, Cardell, Susanna, Rossjohn, Jamie, Godfrey, Dale I., Behar, Samuel M., Besra, Gurdyal S., Brenner, Michael B., Brigl, Manfred

“…CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are Vα14Jα18 ⁺ invariant NKT (iNKT) cells that recognize the…”
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Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways by Schendzielorz, Georg, Dippong, Martin, Grünberger, Alexander, Kohlheyer, Dietrich, Yoshida, Ayako, Binder, Stephan, Nishiyama, Chiharu, Nishiyama, Makoto, Bott, Michael, Eggeling, Lothar

“…Enzymes initiating the biosynthesis of cellular building blocks are frequently inhibited by the end-product of the respective pathway. Here we present an…”
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Pupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis by Küberl, Andreas, Fränzel, Benjamin, Eggeling, Lothar, Polen, Tino, Wolters, Dirk Andreas, Bott, Michael

“…In a manner similar to ubiquitin, the prokaryotic ubiquitin‐like protein (Pup) has been shown to target proteins for degradation via the proteasome in…”
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Acyl-CoA sensing by FasR to adjust fatty acid synthesis in Corynebacterium glutamicum by Irzik, Kristina, van Ooyen, Jan, Gätgens, Jochem, Krumbach, Karin, Bott, Michael, Eggeling, Lothar

“…•We coisolate long-chain fatty acid derivatives together with the regulatory protein FasR.•We show binding of FasR to DNA in dependence of acyl-CoA.•We present…”
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The E2 Domain of OdhA of Corynebacterium glutamicum Has Succinyltransferase Activity Dependent on Lipoyl Residues of the Acetyltransferase AceF by HOFFELDER, Melanie, RAASCH, Katharina, VAN OOYEN, Jan, EGGELING, Lothar

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Identification of a Novel Arabinofuranosyltransferase (AftA) Involved in Cell Wall Arabinan Biosynthesis in Mycobacterium tuberculosis by Alderwick, Luke J., Seidel, Mathias, Sahm, Hermann, Besra, Gurdyal S., Eggeling, Lothar

“…The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis, and is the target of…”
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TetR-type transcriptional regulator FasR of Corynebacterium glutamicum controls genes of lipid synthesis during growth on acetate by Nickel, Jens, Irzik, Kristina, van Ooyen, Jan, Eggeling, Lothar

“…The addition of fatty acids to either Escherichia coli or Bacillus subtilis elicits an elaborate cellular response of the lipid metabolism. We found that in…”
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Identification of a Novel Arabinofuranosyltransferase AftB Involved in a Terminal Step of Cell Wall Arabinan Biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis by Seidel, Mathias, Alderwick, Luke J., Birch, Helen L., Sahm, Hermann, Eggeling, Lothar, Besra, Gurdyal S.

“…Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in the biosynthesis of arabinogalactan, and the anti-tuberculosis agent…”
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three tricarboxylate synthase activities of Corynebacterium glutamicum and increase of l-lysine synthesis by Radmacher, Eva, Eggeling, Lothar

“…Corynebacterium glutamicum owns a citrate synthase and two methylcitrate synthases. Characterization of the isolated enzymes showed that the two methylcitrate…”
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Characterization of a Corynebacterium glutamicum Lactate Utilization Operon Induced during Temperature-Triggered Glutamate Production by STANSEN, Corinna, UY, Davin, DELAUNAY, Stephane, EGGELING, Lothar, GOERGEN, Jean-Louis, WENDISCH, Volker F

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Metabolic Engineering of Corynebacterium glutamicum for l-Serine Production by Peters-Wendisch, Petra, Stolz, Michael, Etterich, Helga, Kennerknecht, Nicole

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The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module by Alderwick, Luke J, Lloyd, Georgina S, Ghadbane, Hemza, May, John W, Bhatt, Apoorva, Eggeling, Lothar, Fütterer, Klaus, Besra, Gurdyal S

“…The D-arabinan-containing polymers arabinogalactan (AG) and lipoarabinomannan (LAM) are essential components of the unique cell envelope of the pathogen…”
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Visualization of Imbalances in Sulfur Assimilation and Synthesis of Sulfur-Containing Amino Acids at the Single-Cell Level by HOFFMANN, Kristina, GRÜNBERGER, Alexander, LAUSBERG, Frank, BOTT, Michael, EGGELING, Lothar

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