Search Results - "EGELHOFF, Thomas T"

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing by Pasapera, Ana M., Plotnikov, Sergey V., Fischer, Robert S., Case, Lindsay B., Egelhoff, Thomas T., Waterman, Clare M.

“…Cell migration requires coordinated formation of focal adhesions (FAs) and assembly and contraction of the actin cytoskeleton. Nonmuscle myosin II (MII) is a…”
Get full text

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion by Thomas, Dustin G, Yenepalli, Aishwarya, Denais, Celine Marie, Rape, Andrew, Beach, Jordan R, Wang, Yu-Li, Schiemann, William P, Baskaran, Harihara, Lammerding, Jan, Egelhoff, Thomas T

“…Non-muscle myosin II (NMII) is reported to play multiple roles during cell migration and invasion. However, the exact biophysical roles of different NMII…”
Get full text

Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration by BETAPUDI, Venkaiah, LICATE, Lucila S, EGELHOFF, Thomas T

“…Initial stages of tumor cell metastasis involve an epithelial-mesenchyme transition that involves activation of amoeboid migration and loss of cell-cell…”
Get full text

Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple‐Negative Breast Cancer by Thiagarajan, Praveena S., Hitomi, Masahiro, Hale, James S., Alvarado, Alvaro G., Otvos, Balint, Sinyuk, Maksim, Stoltz, Kevin, Wiechert, Andrew, Mulkearns‐Hubert, Erin, Jarrar, Awad M., Zheng, Qiao, Thomas, Dustin, Egelhoff, Thomas T., Rich, Jeremy N., Liu, Huiping, Lathia, Justin D., Reizes, Ofer

“…Advanced cancers display cellular heterogeneity driven by self‐renewing, tumorigenic cancer stem cells (CSCs). The use of cell lines to model CSCs is…”
Get full text

Myosin II isoform switching mediates invasiveness after TGF-β–induced epithelial–mesenchymal transition by Beach, Jordan R, Hussey, George S, Miller, Tyler E, Chaudhury, Arindam, Patel, Purvi, Monslow, James, Zheng, Qiao, Keri, Ruth A, Reizes, Ofer, Bresnick, Anne R, Howe, Philip H, Egelhoff, Thomas T

“…Despite functional significance of nonmuscle myosin II in cell migration and invasion, its role in epithelial–mesenchymal transition (EMT) or TGF-β signaling…”
Get full text

Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion by Gupta, Sounak, Hau, Andrew M, Beach, Jordan R, Harwalker, Jyoti, Mantuano, Elisabetta, Gonias, Steven L, Egelhoff, Thomas T, Hansel, Donna E

“…Bladder cancer is the fourth most common cause of cancer in males in the United States. Invasive behavior is a major determinant of prognosis. In this study,…”
Get full text

Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells by Breckenridge, Mark T, Dulyaninova, Natalya G, Egelhoff, Thomas T

“…To better understand the mechanism controlling nonmuscle myosin II (NM-II) assembly in mammalian cells, mutant NM-IIA constructs were created to allow tests in…”
Get full text

ROCK Inhibition Promotes the Development of Chondrogenic Tissue by Improved Mass Transport by Wang, Kuo-Chen, Egelhoff, Thomas T, Caplan, Arnold I, Welter, Jean F, Baskaran, Harihara

“…Human mesenchymal stem cell (hMSC)-based chondrogenesis is a key process used to develop tissue engineered cartilage constructs from stem cells, but the…”
Get more information

Myosin II Recruitment during Cytokinesis Independent of Centralspindlin-mediated Phosphorylation by Beach, Jordan R., Egelhoff, Thomas T.

“…During cell division, the mechanisms by which myosin II is recruited to the contractile ring are not fully understood. Much recent work has focused on a model…”
Get full text

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation by Wang, Yu, Steimle, Paul A, Ren, Yixin, Ross, Christopher A, Robinson, Douglas N, Egelhoff, Thomas T, Sesaki, Hiromi, Iijima, Miho

“…Abnormalities in the huntingtin protein (Htt) are associated with Huntington's disease. Despite its importance, the function of Htt is largely unknown. We show…”
Get full text

Role of B Regulatory Subunits of Protein Phosphatase Type 2A in Myosin II Assembly Control in Dictyostelium discoideum by Rai, Vandana, Egelhoff, Thomas T

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Myosin IIA Heavy Chain Phosphorylation Mediates Adhesion Maturation and Protrusion in Three Dimensions by Rai, Vandana, Thomas, Dustin G, Beach, Jordan R, Egelhoff, Thomas T

“…Non-muscle myosin II (NMII) is a conserved force-producing cytoskeletal enzyme with important but poorly understood roles in cell migration. To investigate…”
Get full text

Matrix-driven Myosin II Mediates the Pro-fibrotic Fibroblast Phenotype by Southern, Brian D., Grove, Lisa M., Rahaman, Shaik O., Abraham, Susamma, Scheraga, Rachel G., Niese, Kathryn A., Sun, Huanxing, Herzog, Erica L., Liu, Fei, Tschumperlin, Daniel J., Egelhoff, Thomas T., Rosenfeld, Steven S., Olman, Mitchell A.

“…Pro-fibrotic mesenchymal cells are known to be the key effector cells of fibroproliferative disease, but the specific matrix signals and the induced cellular…”
Get full text

Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2–Dependent Bladder Cancer Cell Migration and Invasion by Gupta, Sounak, Hau, Andrew M, Al-Ahmadie, Hikmat A, Harwalkar, Jyoti, Shoskes, Aaron C, Elson, Paul, Beach, Jordan R, Hussey, George S, Schiemann, William P, Egelhoff, Thomas T, Howe, Philip H, Hansel, Donna E

“…Our prior work identified the mammalian target of rapamycin complex 2 (mTORC2) as a key regulator of bladder cancer cell migration and invasion, although…”
Get full text

A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration by Betapudi, Venkaiah, Gokulrangan, Giridharan, Chance, Mark R., Egelhoff, Thomas T.

“…Myosin II motor proteins play important roles in cell migration. Although myosin II filament assembly plays a key role in the stabilization of focal contacts…”
Get full text

Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality by Crish, James, Conti, Mary Anne, Sakai, Takao, Adelstein, Robert S., Egelhoff, Thomas T.

“…In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described…”
Get full text

A microfluidic imaging chamber for the direct observation of chemotactic transmigration by Breckenridge, Mark T., Egelhoff, Thomas T., Baskaran, Harihara

“…To study the roles of nonmuscle myosin II (NM-II) during invasive cell migration, microfluidic migration chambers have been designed and fabricated using…”
Get full text

Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration by Liang, Wenchuan, Licate, Lucila, Warrick, Hans, Spudich, James, Egelhoff, Thomas

“…Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration, and in the cleavage furrow…”
Get full text

Generation of double gene disruptions in Dictyostelium discoideum using a single antibiotic marker selection by Betapudi, Venkaiah, Shoebotham, Karen, Egelhoff, Thomas T

“…Gene targeting is a powerful molecular genetic technique that has been widely used to understand specific gene function in vivo. This technique allows the…”
Get full text

Roles of an Unconventional Protein Kinase and Myosin II in Amoeba Osmotic Shock Responses by Betapudi, Venkaiah, Egelhoff, Thomas T

“…The contractile vacuole (CV) is a dynamic organelle that enables Dictyostelium amoeba and other protist to maintain osmotic homeostasis by expelling excess…”
Get full text