Search Results - "EFFLAND, R. C"

Synthesis and Structure−Activity Relationships of N-Propyl-N-(4-pyridinyl)-1H-indol-1-amine (Besipirdine) and Related Analogs as Potential Therapeutic Agents for Alzheimer's Disease by Klein, Joseph T, Davis, Larry, Olsen, Gordon E, Wong, George S, Huger, Francis P, Smith, Craig P, Petko, Wayne W, Cornfeldt, Michael, Wilker, Jeffrey C, Blitzer, R. D, Landau, E, Haroutunian, V, Martin, Lawrence L, Effland, Richard C

“…A series of novel N-(4-pyridinyl)-1H-indol-1-amines and other heteroaryl analogs was synthesized and evaluated in tests to determine potential utility for the…”
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Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease by Fink, David M, Bores, Gina M, Effland, Richard C, Huger, Francis P, Kurys, Barbara E, Rush, Douglas K, Selk, David E

“…A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors. The compounds are related to hyperzine A, a…”
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Stereoselective R-(+) enantiomer of HA-966 displays anxiolytic effects in rodents by Dunn, R W, Flanagan, D M, Martin, L L, Kerman, L L, Woods, A T, Camacho, F, Wilmot, C A, Cornfeldt, M L, Effland, R C, Wood, P L

“…Anxiolytic agents disinhibit suppressed behaviors in rodents in preclinical models of anxiety such as the non-conditioned social interaction and elevated plus…”
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Substituted (Pyrroloamino)pyridines:  Potential Agents for the Treatment of Alzheimer's Disease by Davis, Larry, Klein, Joseph T, Kapples, Kevin J, Huger, Francis P, Smith, Craig P, Petko, Wayne W, Cornfeldt, Michael, Effland, Richard C

“…A novel series of substituted (pyrroloamino)pyridines was synthesized, and the compounds were evaluated for cholinomimetic-like properties in vitro (inhibition…”
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2,3-Dihydro-3-(1-pyrryl)spiro[benzofuran-2,4'-piperidine]s and 2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,3'-pyrrolidine]s: novel antihypertensive agents by Davis, Larry, Agnew, Marc N, Effland, Richard C, Klein, Joseph T, Kitzen, Jan M, Schwenkler, Mary A

“…A series of 2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,4'-piperidine]s (IV) and 2,3-dihydro-3-(1-pyrryl)spiro[benzofuran-2,3'-pyrrolidine]s (V) was synthesized…”
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Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitor by Martin, Lawrence L., Davis, Larry, Klein, Joseph T., Nemoto, Peter, Olsen, Gordon E., Bores, Gina M., Camacho, Fernando, Petko, Wayne W., Rush, Douglas K., Selk, David, Smith, Craig P., Vargas, Hugo M., Winslow, James T., Effland, Richard C., Fink, David M.

“…A series of carbamate analogs of besipirdine (HP 749) was synthesized as potential agents with enhanced cholinomimetic properties for the treatment of…”
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Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography by Hsu, R S, DiLeo, E M, Chesson, S M, Klein, J T, Effland, R C

“…N-(n-Propyl)-N-(4-pyridinyl)-1H-indol-1-amine hydrochloride (HP 749, I), a non-receptor-dependent cholinomimetic agent with noradrenergic activity, is a…”
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4-aminopyridine derivatives: A family of novel modulators of voltage-dependent sodium channels by Tang, Lei, Huger, Francis P., Klein, Joseph T., Davis, Larry, Martin, Lawrence L., Shimshock, Stephen, Effland, Richard C., Smith, Craig P., Kongsamut, Sathapana

“…The interactions of a family of aminopyridine derivatives with Site II of the voltage‐dependent sodium channel were examined by measuring the ability of these…”
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3-substituted-1,2-benzisoxazoles: novel antipsychotic agents by Davis, L, Effland, R C, Klein, J T, Dunn, R W, Geyer, 3rd, H M, Petko, W W

“…A series of 3-substituted-6-fluoro-1,2-benzisoxazoles (II) was synthesized and evaluated for potential antipsychotic activity. Many of the compounds displayed…”
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Synthesis of novel pyrido[3,4-f]pyrrolo[1,2-b][1,2,5]triazepines. A Novel heterocyclic ring system by Effland, Richard C., Davis, Larry, Kapples, Kevin J., Olsen, Gordon E.

“…The synthesis of novel pyrido[3,4‐f]pyrrolo[1,2‐b][1,2,5]triazepines 6–17 is described. Subsequent reactions on the parent system include reduction, Grignard…”
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Synthesis of 2′,3′-dihydrospiro[benzofuran-2(3H),4′(1′-H)isoquinoline]s. A novel heterocyclic ring system by Klein, Joseph T., Davis, Larry, Effland, Richard C.

“…The synthesis of a novel 2′,3′‐dihydrospiro(benzofuran‐2(3H),4′(1′H)isoquinoline] ring system (IV) by a nucleophilic aromatic fluoride displacement‐cyclization…”
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Synthesis of pyrrolo[1,2-b]cinnolines by Hamer, R. Richard L., Sekerak, Danette, Effland, Richard C., Klein, Joseph T.

“…The synthesis of the pyrrolo[1,2‐b]cinnoline analogs 2 and 4–13 is described. The key step of this synthesis involves an intramolecular aromatic halide…”
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Synthesis of carboxyarylindoles and benzofurans as nonsteroidal antiinflammatory agents by Effland, Richard C

“…2-Carboxyaryl-substituted dihydrobenz[e]indoles, tetrahydroindoles, and tetrahydrobenzofurans have been synthesized as structural analogues of fendosal, a new…”
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[(3-Aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series by Shutske, Gregory M, Setescak, Linda L, Allen, Richard C, Davis, Larry, Effland, Richard C, Ranbom, Karen, Kitzen, Jan M, Wilker, Jeffrey C, Novick, William J

“…A series of [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids was synthesized and tested for diuretic activity in saline-loaded mice and in conscious,…”
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Synthesis of 5-phenylpyrrolo[1,2-b][1,2,5]-triazepin-2(3H)-ones by Hamer, R. Richard L., Effland, Richard C., Klein, Joseph T., Huger, Francis P., Wilker, Jeffrey C.

“…The synthesis of a series of 5‐phenylpyrrolo[1,2‐b][1,2,5]triazepin‐2(3H)‐ones 1 as potential anxiolytic agents is described. Benzoylation of…”
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Pyrrolo[2,1-c][1,4]benzoxazepines. II: Synthesis of 5-phenyl derivatives by KAPPLES, K. J, EFFLAND, R. C

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Synthesis of pyrrolo[2,1-c][1,4]benzoxazepines. I: A novel heterocyclic ring system by EFFLAND, R. C, DAVIS, L

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Pyrrolo[2,1-c][1,4]benzoxazepines. 2. Synthesis of 5-phenyl derivatives by Kapples, Kevin J., Effland, Richard C.

“…A series of 5‐phenylpyrrolo[2,1‐c][1,4]benzoxazepines with basic substituents at the 11‐position has been synthesized utilizing a nucleophilic aromatic…”
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Synthesis of pyrrolo[2,1-c][1,4]benzoxazepines. 1. A novel heterocyclic ring system by Effland, Richard C., Davis, Larry

“…The synthesis of a novel pyrrolo[2,1‐c][1,4]benzoxazepine ring system (II) by a nucleophilic aromatic fluoride displacement‐cyclization is described…”
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Synthesis of 2,3-dihydrospiro[benzofuran-2,4′ -piperidines] and 2,3-dihydrospiro[benzofuran-2,3′-pyrrolidines] by Effland, Richard C., Gardner, Beth Ann, Strupczewski, Joseph

“…The synthesis of 2,3‐dihydrospiro[benzofuran‐2,4′‐piperidines] 3 and 2,3‐dihydrospiro[benzofuran‐2,3′]‐pyrrolidine] 6 is described. The synthesis was achieved…”
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