Search Results - "EDWARDS, Paul"

Complex multi-enhancer contacts captured by genome architecture mapping by Beagrie, Robert A., Scialdone, Antonio, Schueler, Markus, Kraemer, Dorothee C. A., Chotalia, Mita, Xie, Sheila Q., Barbieri, Mariano, de Santiago, Inês, Lavitas, Liron-Mark, Branco, Miguel R., Fraser, James, Dostie, Josée, Game, Laurence, Dillon, Niall, Edwards, Paul A. W., Nicodemi, Mario, Pombo, Ana

“…The organization of the genome in the nucleus and the interactions of genes with their regulatory elements are key features of transcriptional control and…”
Get full text

Infrastructure studies meet platform studies in the age of Google and Facebook by Plantin, Jean-Christophe, Lagoze, Carl, Edwards, Paul N, Sandvig, Christian

“…Two theoretical approaches have recently emerged to characterize new digital objects of study in the media landscape: infrastructure studies and platform…”
Get full text

Challenge of Atropisomerism in Drug Discovery by Clayden, Jonathan, Moran, Wesley J, Edwards, Paul J, LaPlante, Steven R

“…A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or…”
Get full text

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing by Edkins, Sarah, Santarius, Thomas, Goodhead, Ian, Edwards, Paul A W, Menzies, Andrew, Bignell, Graham R, Pleasance, Erin D, Stephens, Philip J, O'Meara, Sarah, Stebbings, Lucy A, Hardy, Claire, Brown, Clive, Li, Heng, Turner, Daniel J, Cox, Antony, Campbell, Peter J, Quail, Michael A, Teague, Jon W, Leroy, Catherine, Durbin, Richard, Clee, Christopher M, Futreal, P Andrew, Stratton, Michael R, Hurles, Matthew E

“…Human cancers often carry many somatically acquired genomic rearrangements, some of which may be implicated in cancer development. However, conventional…”
Get full text

Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation by Edwards, Paul AW

“…Much of tumour cell biology and the tumour microenvironment may be normal wound‐healing responses as a consequence of the disruption of tissue structure. This…”
Get full text

When should workers embrace or resist new technology? by Edwards, Paul, Ramirez, Paulina

“…The question of how workers might respond to new technologies has lurked behind many debates on the subject. It has not been posed directly, in part because of…”
Get full text

Definition and classification of fault damage zones: A review and a new methodological approach by Choi, Jin-Hyuck, Edwards, Paul, Ko, Kyoungtae, Kim, Young-Seog

“…Although the widths of fault damage zones commonly show a positive correlation with displacements, these relationships also show a somewhat scattered…”
Get full text

The essence of trade unions: understanding identity, ideology and purpose by Hodder, Andy, Edwards, Paul

“…Academics have long investigated trade union behaviour through the complex interaction of identity, ideology and purpose. At the same time, there have been…”
Get full text

Conflict and control in the contemporary workplace: Structured antagonism revisited by Edwards, Paul, Hodder, Andy

“…The concept of a structured antagonism lying at the heart of the employment relationship is widely cited but also commonly misinterpreted. The paper firstly…”
Get full text

Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium by Li, Yue, Gappy, Shawn, Liu, Xiuli, Sassalos, Therese, Zhou, Tongrong, Hsu, Andrew, Zhang, Alice, Edwards, Paul A, Gao, Hua, Qiao, Xiaoxi

“…Metformin is a traditional anti-hyperglycemic medication that has recently been shown to benefit vascular complications of diabetes via an anti-inflammatory…”
Get full text

Material flow during friction stir welding of Ti-6Al-4V by Edwards, Paul D., Ramulu, M.

“…6mm thick Ti-6Al-4V butt joints were produced with a tracer material embedded in the joint under a variety of process conditions, namely rotational speed and…”
Get full text

NRG1 fusions in breast cancer by Howarth, Karen D, Mirza, Tashfina, Cooke, Susanna L, Chin, Suet-Feung, Pole, Jessica C, Turro, Ernest, Eldridge, Matthew D, Garcia, Raquel Manzano, Rueda, Oscar M, Boursnell, Chris, Abraham, Jean E, Caldas, Carlos, Edwards, Paul A W

“…NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors. The NRG1 gene…”
Get full text

Fusion genes and chromosome translocations in the common epithelial cancers by Edwards, Paul AW

“…It has been known for 25 years that fusion genes play a central role in leukaemias and sarcomas but they have been neglected in the common carcinomas, largely…”
Get full text

History of climate modeling by Edwards, Paul N.

“…The history of climate modeling begins with conceptual models, followed in the 19th century by mathematical models of energy balance and radiative transfer, as…”
Get full text

Institutions, Infrastructures, and Innovation by Edwards, Paul N., King, John Leslie

“…Innovators, institutions, and infrastructures are hidden but essential to innovation ecologies that produced important breakthroughs. This article provides…”
Get full text

Making ‘Critical Performativity’ Concrete: Sumantra Ghoshal and Linkages between the Mainstream and the Critical by Edwards, Paul K.

“…Critical performativity (CP) advocates direct engagement with managerial practice to promote social change while being subversive of a focus on efficiency. Its…”
Get full text

Assessing Atropisomer Axial Chirality in Drug Discovery and Development by LaPlante, Steven R, D. Fader, Lee, Fandrick, Keith R, Fandrick, Daniel R, Hucke, Oliver, Kemper, Ray, Miller, Stephen P. F, Edwards, Paul J

Get full text

Critical performativity and the small firm: Challenges and prospects by Edwards, Paul

“…The idea of engaging directly with management practice while retaining a strongly critical social science stance has become popular under the banner of…”
Get full text

Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin by Brown, Sarah D, Nativo, Paola, Smith, Jo-Ann, Stirling, David, Edwards, Paul R, Venugopal, Balaji, Flint, David J, Plumb, Jane A, Graham, Duncan, Wheate, Nial J

“…The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting…”
Get full text

Knowledge infrastructures for the Anthropocene by Edwards, Paul N

“…The technosphere metabolizes not only energy and materials, but information and knowledge as well. This article first examines the history of knowledge about…”
Get full text