Search Results - "EDWARDS, Jeffrey E"

Acute Passive Static Stretching and Cramp Threshold Frequency by Panza, Gino, Stadler, Justin, Murray, Donal, Lerma, Nicholas, Barrett, Tomas, Pettit-Mee, Ryan, Edwards, Jeffrey E

“…Exercise-associated muscle cramps are a common clinical problem for athletes.   To determine whether acute passive static stretching altered cramp threshold…”
Get full text

Effect of knee joint effusion on quadriceps and soleus motoneuron pool excitability by HOPKINS, Jon T, INGERSOLL, Christopher D, KRAUSE, B. Andrew, EDWARDS, Jeffrey E, CORDOVA, Mitchell L

“…To examine changes in quadriceps and soleus MN pool activity resulting from knee joint effusion over a 4-h period and assess the relationship between the…”
Get full text

APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology by Adams, John W, Ramirez, Juan, Shi, Yunqing, Thomsen, William, Frazer, John, Morgan, Michael, Edwards, Jeffrey E, Chen, Weichao, Teegarden, Bradley R, Xiong, Yifeng, Al-Shamma, Hussien, Behan, Dominic P, Connolly, Daniel T

“…We have evaluated the receptor pharmacology, antiplatelet activity, and vascular pharmacology of APD791…”
Get more information

The relationship between intramuscular temperature, skin temperature, and adipose thickness during cryotherapy and rewarming by Jutte, Lisa S., Merrick, Mark A., Ingersoll, Christopher D., Edwards, Jeffrey E.

“…ABSTRACT Jutte LS, Merrick MA, Ingersoll CD, Edwards JE. The relationship between intramuscular temperature, skin temperature, and adipose thickness during…”
Get full text

A new family of H3 receptor antagonists based on the natural product Conessine by SANTORA, Vincent J, COVEL, Jonathan A, WEBB, Robert R, SAGE, Carleton, REN, Albert, PEREIRA, Guilherme, KNUDSEN, Jens, EDWARDS, Jeffrey E, SUAREZ, Marissa, FRAZER, John, THOMSEN, William, HAUSER, Erin, HAYASHI, Rena, WHELAN, Kevin, GROTTICK, Andrew J, HOFILENA, Brian J, IBARRA, Jason B, PULLEY, Michelle D, WEINHOUSE, Michael I, SENGUPTA, Dipanjan, DUFFIELD, Jonathan J, SEMPLE, Graeme

“…A new family of Histamine H(3) receptor antagonists (5a-t) has been prepared based on the structure of the natural product Conessine, a known H(3) antagonist…”
Get full text

Muscle cramp susceptibility increases following a volitionally induced muscle cramp by Miller, Kevin C., Long, Blaine C., Edwards, Jeffrey E.

“…ABSTRACT Introduction Muscle cramping may increase peripheral nervous system excitability. It is unknown if, and how long, cramp susceptibility is affected by…”
Get full text

GF120918, a P-Glycoprotein Modulator, Increases the Concentration of Unbound Amprenavir in the Central Nervous System in Rats by EDWARDS, Jeffrey E, BROUWER, Kenneth R, MCNAMARA, Patrick J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Role of P-Glycoprotein in Distribution of Nelfinavir across the Blood-Mammary Tissue Barrier and Blood-Brain Barrier by EDWARDS, Jeffrey E, ALCORN, Jane, SAVOLAINEN, Juoko, ANDERSON, Bradley D, MCNAMARA, Patrick J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects by Edwards, Jeffrey E., Eliot, Lise, Parkinson, Andrew, Karan, Sharon, MacConell, Leigh

“…Introduction Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC)…”
Get full text

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916) by Semple, Graeme, Santora, Vincent J., Smith, Jeffrey M., Covel, Jonathan A., Hayashi, Rena, Gallardo, Charlemagne, Ibarra, Jason B., Schultz, Jeffrey A., Park, Douglas M., Estrada, Scott A., Hofilena, Brian J., Smith, Brian M., Ren, Albert, Suarez, Marissa, Frazer, John, Edwards, Jeffrey E., Hart, Ryan, Hauser, Erin K., Lorea, Jodie, Grottick, Andrew J.

“…The design of a new clinical candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described…”
Get full text

Evidence of FXR Activation with Obeticholic Acid in an in Vitro Intestinal Model by Zhang, Yuanyuan, LaCerte, Carl, Brouwer, Kenneth R, Jackson, Jonathan P, Kansra, Sanjay, Edwards, Jeffrey E

Get full text

Does a Reduction in Serum Sodium Concentration or Serum Potassium Concentration Increase the Prevalence of Exercise-Associated Muscle Cramps? by Murray, Donal, Miller, Kevin C, Edwards, Jeffrey E

“…Although exercise-associated muscle cramps (EAMC) are common in ultradistance runners and athletes in general, their etiology remains unclear. EAMC are…”
Get more information

Sa1576 Exposure-Response Relationship of Obeticholic Acid for Alkaline Phosphatase and Total Bilirubin in Patients With Primary Biliary Cirrhosis (PBC) by Edwards, Jeffrey E, LaCerte, Carl, Pheng, Leng Hong, Peyret, Thomas, Gosselin, Nathalie, Marier, JF, Shapiro, David

Get full text

Effects of a P-Glycoprotein Inhibitor on Brain and Plasma Concentrations of Anti-Human Immunodeficiency Virus Drugs Administered in Combination in Rats by SAVOLAINEN, Jouko, EDWARDS, Jeffrey E, MORGAN, Michael E, MCNAMARA, Patrick J, ANDERSON, Bradley D

“…Most of the existing anti-human immunodeficiency virus agents enter the central nervous system (CNS) inefficiently and thus may allow slow viral replication in…”
Get full text

Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models by Zhang, Yuanyuan, LaCerte, Carl, Kansra, Sanjay, Jackson, Jonathan P., Brouwer, Kenneth R., Edwards, Jeffrey E.

“…Obeticholic acid (OCA) is a semisynthetic farnesoid X receptor (FXR) agonist, an analogue of chenodeoxycholic acid (CDCA) which is indicated for the treatment…”
Get full text

Eccentric and concentric strength of the shoulder and arm musculature in collegiate baseball pitchers by Mikesky, A E, Edwards, J E, Wigglesworth, J K, Kunkel, S

“…Many pitching injuries occur during deceleration of the upper extremity when the muscles of the shoulder and arm are acting eccentrically. Published…”
Get more information

Obeticholic acid, a selective farnesoid X receptor agonist, regulates bile acid homeostasis in sandwich‐cultured human hepatocytes by Zhang, Yuanyuan, Jackson, Jonathan P., St. Claire, Robert L., Freeman, Kimberly, Brouwer, Kenneth R., Edwards, Jeffrey E.

“…Farnesoid X receptor (FXR) is a master regulator of bile acid homeostasis through transcriptional regulation of genes involved in bile acid synthesis and…”
Get full text

Pre-synaptic modulation of quadriceps arthrogenic muscle inhibition by Palmieri, Riann M, Weltman, Arthur, Edwards, Jeffrey E, Tom, James A, Saliba, Ethan N, Mistry, Danny J, Ingersoll, Christopher D

“…Arthrogenic muscle inhibition (AMI) impedes rehabilitation following knee joint injury by preventing activation of the quadriceps. AMI has been attributed to…”
Get full text

Exercise-Associated Muscle Cramps: Causes, Treatment, and Prevention by Miller, Kevin C., Stone, Marcus S., Huxel, Kellie C., Edwards, Jeffrey E.

“…Context: Exercise-associated muscle cramps (EAMC) are a common condition experienced by recreational and competitive athletes. Despite their commonality and…”
Get full text

Threshold frequency of an electrically induced cramp increases following a repeated, localized fatiguing exercise by Stone, Marcus B., Edwards, Jeffrey E., Huxel, Kellie C., Cordova, Mitchell L., Ingersoll, Christopher D., Patrick Babington, J.

“…Though clinical observations and laboratory data provide some support for the neuromuscular imbalance theory of the genesis of exercise-associated muscle…”
Get full text