Search Results - "EDWARDS, Christopher J"

Rheumatoid arthritis in the elderly: Characteristics and treatment considerations by Serhal, Lina, Lwin, May N., Holroyd, Christopher, Edwards, Christopher J.

“…The elderly rheumatoid arthritis (RA) population consists of both elderly-onset RA that manifests after the age of 60 and individuals diagnosed with RA early…”
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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis by Reeves, Emma, Colebatch-Bourn, Alexandra, Elliott, Tim, Edwards, Christopher J., James, Edward

“…For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the…”
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Rheumatoid Arthritis: The Impact of Mental Health on Disease: A Narrative Review by Lwin, May N., Serhal, Lina, Holroyd, Christopher, Edwards, Christopher J.

“…Over 60% of rheumatoid arthritis (RA) patients achieve a good response after 12 months of treatment when following the European league against rheumatism…”
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Safety of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis by Sepriano, Alexandre, Kerschbaumer, Andreas, Bergstra, Sytske Anne, Smolen, Josef S, van der Heijde, Désirée, Caporali, Roberto, Edwards, Christopher J, Verschueren, Patrick, de Souza, Savia, Pope, Janet, Takeuchi, Tsutomu, Hyrich, Kimme, Winthrop, Kevin L, Aletaha, Daniel, Stamm, Tanja, Schoones, Jan W, Landewé, Robert B M

“…To perform a systematic literature review (SLR) concerning the safety of synthetic(s) and biological (b) disease-modifying antirheumatic drugs (DMARDs) to…”
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Long-term experience with apremilast in patients with psoriatic arthritis: 5-year results from a PALACE 1-3 pooled analysis by Kavanaugh, Arthur, Gladman, Dafna D, Edwards, Christopher J, Schett, Georg, Guerette, Benoit, Delev, Nikolay, Teng, Lichen, Paris, Maria, Mease, Philip J

“…The efficacy and safety of apremilast were assessed in patients with psoriatic arthritis (PsA) in three phase III clinical trials with similar designs (PALACE…”
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Randomized Controlled Trial of Rituximab and Cost‐Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome by Bowman, Simon J., Everett, Colin C., O'Dwyer, John L., Emery, Paul, Pitzalis, Costantino, Ng, Wan‐Fai, Pease, Colin T., Price, Elizabeth J., Sutcliffe, Nurhan, Gendi, Nagui S. T., Hall, Frances C., Ruddock, Sharon P., Fernandez, Catherine, Reynolds, Catherine, Hulme, Claire T., Davies, Kevin A., Edwards, Christopher J., Lanyon, Peter C., Moots, Robert J., Roussou, Euthalia, Giles, Ian P., Sharples, Linda D., Bombardieri, Michele

“…Objective To investigate whether rituximab, an anti–B cell therapy, improves symptoms of fatigue and oral dryness in patients with primary Sjögren's syndrome…”
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Free educational material on the EULAR school of rheumatology website by Edwards, Christopher J

“…There is lots of educational content including free educational material for all those interested in rheumatic and musculoskeletal diseases (RMDs) on the EULAR…”
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Prevalence of cognitive impairment in patients with rheumatoid arthritis: a cross sectional study by McDowell, Bethany, Marr, Calum, Holmes, Clive, Edwards, Christopher J, Cardwell, Christopher, McHenry, Michelle, Meenagh, Gary, McGuinness, Bernadette

“…To explore the role of chronic inflammation in rheumatoid arthritis (RA) on cognition. Six hundred sixty-one men and women aged ≥55 years who fulfilled the…”
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Fitting psychotherapy to patient coping style: A meta‐analysis by Beutler, Larry E., Kimpara, Satoko, Edwards, Christopher J., Miller, Kimberley D.

“…Over the course of 60 years of research, several personality traits have emerged as potential predictors of differential change in psychotherapy. Among them is…”
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Efficacy of subcutaneous vs intravenous infliximab in rheumatoid arthritis: a post-hoc analysis of a randomized phase III trial by Constantin, Arnaud, Caporali, Roberto, Edwards, Christopher J, Fonseca, João Eurico, Iannone, Florenzo, Keystone, Edward, Schulze-Koops, Hendrik, Kwon, Taek, Kim, Seungmin, Yoon, SangWook, Kim, Dong-Hyeon, Park, Gahee, Yoo, Dae Hyun

“…Abstract Objectives The primary endpoint of the pivotal phase III study of infliximab (IFX) s.c. demonstrated non-inferiority of s.c. to i.v. IFX, based on…”
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Lifetime risk of knee and hip replacement following a diagnosis of RA: findings from a cohort of 13 961 patients from England by Burn, Edward, Edwards, Christopher J, Murray, David W, Silman, Alan, Cooper, Cyrus, Arden, Nigel K, Pinedo-Villanueva, Rafael, Prieto-Alhambra, Daniel

“…Abstract Objective To estimate the lifetime risk of knee and hip replacement following a diagnosis of RA. Methods The analysis was undertaken using routinely…”
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Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis) by Colebatch, Alexandra N, Marks, Jonathan L, Edwards, Christopher J

“…Methotrexate is routinely used in the treatment of inflammatory arthritis. There have been concerns regarding the safety of using concurrent non-steroidal…”
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Amongst patients taking biologic therapies for axial spondyloarthritis, which factors are associated with work non-participation? by Nadin, Tom, Wallis, Dinny, Holroyd, Christopher R, D'Angelo, Stefania, Walker-Bone, Karen, Edwards, Christopher J

“…Axial spondyloarthritis (axSpA) frequently presents during working age and therefore impacts work participation. Biologic therapies have demonstrated a…”
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The effect of rheumatoid arthritis on patient-reported outcomes following knee and hip replacement: evidence from routinely collected data by Burn, Edward, Edwards, Christopher J, Murray, David W, Silman, Alan, Cooper, Cyrus, Arden, Nigel K, Pinedo-Villanueva, Rafael, Prieto-Alhambra, Daniel

“…To compare outcomes of total knee replacement (TKR) and total hip replacement (THR) for individuals with RA and OA. We performed a cohort study using routinely…”
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ERAP1 in the pathogenesis of ankylosing spondylitis by Reeves, Emma, Elliott, Tim, James, Edward, Edwards, Christopher J.

“…The endoplasmic reticulum aminopeptidase 1 (ERAP1) performs a major role in antigen processing, trimming N-terminally extended peptides to the final epitope…”
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Treat to target in RA: how strict should we be in the pursuit of remission? by Edwards, Christopher J

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"Patient's Family Wants an Update": A Curriculum for Senior Medical Students to Deliver Telephone Updates for Hospitalized Patients by Edwards, Christopher J, Fitzgerald, James T, Heidemann, Lauren A

“…Residents have the important task of updating family members of hospitalized patients, often by telephone. There are limited curricula dedicated to preparing…”
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Reply to Robinson and Brown: It is the combination of ERAP1 allotypes that identifies individuals with Ankylosing Spondylitis by Reeves, Emma, Colebatch-Bourn, Alexandra, Elliott, Tim, Edwards, Christopher J., James, Edward

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How important is JAK1 selectivity? by Edwards, Christopher J

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Tyrosine kinase 2 inhibitors in autoimmune diseases by Ramakrishna, Chethana, Mason, Alice, Edwards, Christopher J.

“…Tyk2 is a member of the JAK kinase family. It is an important mediator in pro-inflammatory signalling, implicated in both innate and adaptive immune system…”
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