Search Results - "EDGERTON, Mary E"

Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing by Casasent, Anna K., Schalck, Aislyn, Gao, Ruli, Sei, Emi, Long, Annalyssa, Pangburn, William, Casasent, Tod, Meric-Bernstam, Funda, Edgerton, Mary E., Navin, Nicholas E.

“…Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses to invasive ductal carcinoma (IDC). Genomic evolution has been…”
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Prediction of Drug Response in Breast Cancer Using Integrative Experimental/Computational Modeling by FRIEBOES, Hermann B, EDGERTON, Mary E, FRUEHAUF, John P, ROSE, Felicity R. A. J, WORRALL, Lisa K, GATENBY, Robert A, FERRARI, Mauro, CRISTINI, Vittorio

“…Nearly 30% of women with early-stage breast cancer develop recurrent disease attributed to resistance to systemic therapy. Prevailing models of chemotherapy…”
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Ductal Carcinoma in Situ: State of the Science and Roadmap to Advance the Field by KUERER, Henry M, ALBARRACIN, Constance T, BABIERA, Gildy, EDGERTON, Mary E, CZERNIECKI, Brian J, ARUN, Banu K, HORTOBAGYI, Gabriel N, YANG, Wei T, CARDIFF, Robert D, BREWSTER, Abenaa M, FRASER SYMMANS, W, HYLTON, Nola M, MIDDLETON, Lavinia P, KRISHNAMURTHY, Savitri, PERKINS, George H

“…Ductal carcinoma in situ (DCIS) is the fourth leading cancer for women in the United States. Understanding of the biology and clinical behavior of DCIS is…”
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Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression by Macklin, Paul, Edgerton, Mary E., Thompson, Alastair M., Cristini, Vittorio

“…Ductal carcinoma in situ (DCIS)—a significant precursor to invasive breast cancer—is typically diagnosed as microcalcifications in mammograms. However, the…”
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Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer by Thompson, Patricia A, Brewster, Abenaa M, Kim-Anh, Do, Baladandayuthapani, Veerabhadran, Broom, Bradley M, Edgerton, Mary E, Hahn, Karin M, Murray, James L, Sahin, Aysegul, Tsavachidis, Spyros, Wang, Yuker, Zhang, Li, Hortobagyi, Gabriel N, Mills, Gordon B, Bondy, Melissa L

“…A number of studies of copy number imbalances (CNIs) in breast tumors support associations between individual CNIs and patient outcomes. However, no pattern or…”
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Early Involvement of the Phosphatidylinositol 3-Kinase/Akt Pathway in Lung Cancer Progression by Massion, Pierre P, Taflan, Peter M, Shyr, Yu, Rahman, S. M. Jamshedur, Yildiz, Pinar, Shakthour, Bashar, Edgerton, Mary E, Ninan, Matthew, Andersen, Jeremiah J, Gonzalez, Adriana L

“…Signaling through the phosphatidylinositol 3-kinase (PI3-kinase) pathway has been associated with lung tumorigenesis. We examined the association between gene…”
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Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family by Sanga, Sandeep, Broom, Bradley M, Cristini, Vittorio, Edgerton, Mary E

“…Pathway discovery from gene expression data can provide important insight into the relationship between signaling networks and cancer biology. Oncogenic…”
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The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes by Han, Leng, Yuan, Yuan, Zheng, Siyuan, Yang, Yang, Li, Jun, Edgerton, Mary E., Diao, Lixia, Xu, Yanxun, Verhaak, Roeland G. W., Liang, Han

“…Although individual pseudogenes have been implicated in tumour biology, the biomedical significance and clinical relevance of pseudogene expression have not…”
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A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast by Edgerton, Mary E, Chuang, Yao-Li, Macklin, Paul, Yang, Wei, Bearer, Elaine L, Cristini, Vittorio

“…We introduce a novel “mathematical pathology” approach, founded on a biophysical model, to identify robust patient-specific predictors of tumor growth useful…”
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Challenges of the information age: the impact of false discovery on pathway identification by Rog, Colin J, Chekuri, Srinivasa C, Edgerton, Mary E

“…Pathways with members that have known relevance to a disease are used to support hypotheses generated from analyses of gene expression and proteomic studies…”
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Utility of Whole Slide Imaging for Intraoperative Consultation: Experience of a Large Academic Center by Shehabeldin, Ahmed, Rohra, Prih, Sellen, Linton D, Zhao, Jianping, Alqaidy, Doaa, Aramin, Hermineh, Hameed, Nadia, Perez, Ydamis Estrella, Lai, Zongshan, Tong, Yi Tat, Milton, Denái R, Edgerton, Mary E, Fuller, Gregory, Hansel, Donna, Prieto, Victor G, Ballester, Leomar Y, Aung, Phyu P

“…In the United States, review of digital whole slide images (WSIs) using specific systems is approved for primary diagnosis but has not been implemented for…”
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The deployment of a tissue request tracking system for the CHTN: a case study in managing change in informatics for biobanking operations by Edgerton, Mary E, Grizzle, William E, Washington, M Kay

“…Managing change has not only been recognized as an important topic in medical informatics, but it has become increasingly important in translational…”
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Multiplicity: an organizing principle for cancers and somatic mutations by Frey, Lewis J, Piccolo, Stephen R, Edgerton, Mary E

“…With the advent of whole-genome analysis for profiling tumor tissue, a pressing need has emerged for principled methods of organizing the large amounts of…”
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Exploring the College of American Pathologists Electronic Cancer Checklists: What They Are and What They Can Do for You by Torous, Vanda F, Allan, Robert W, Balani, Jyoti, Baskovich, Brett, Birdsong, George G, Dellers, Elizabeth, Dryden, Mignon, Edgerton, Mary E, Giannico, Giovanna A, Heayn, Michelle, Jackson, Christopher R, Klepeis, Veronica E, Olson, Jordan E, Pettus, Jason R, Simpson, Ross W, Sirintrapun, S Joseph, Smith, Deven L, Srigley, John R, Berman, Michael A

“…In order to make use of the eCC, the end user (the pathologist) must have access to a laboratory information system or to a third-party vendor that integrates…”
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2013 HIPAA Changes Provide Opportunities and Challenges for Researchers: Perspectives from a Cancer Center by Freedman, Ralph S, Cantor, Scott B, Merriman, Kelly W, Edgerton, Mary E

“…In 2013, the U.S. Department of Health and Human Services modified the Health Insurance Portability and Accountability Act Privacy Rule to "strengthen privacy…”
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Analysis of laboratory data transmission between two healthcare institutions using a widely used point-to-point health information exchange platform: a case report by Luu, Hung S, Campbell, Walter S, Cholan, Raja A, Edgerton, Mary E, Englund, Andrea, Keller, Alana, Korte, Elizabeth D, Mitchell, Sandra H, Watkins, Greg T, Westervelt, Lindsay, Wyman, Daniel, Powell, Stephen

“…The objective was to identify information loss that could affect clinical care in laboratory data transmission between 2 health care institutions via a Health…”
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DCIS Margins and Breast Conservation: MD Anderson Cancer Center Multidisciplinary Practice Guidelines and Outcomes by Kuerer, Henry M, Smith, Benjamin D, Chavez-MacGregor, Mariana, Albarracin, Constance, Barcenas, Carlos H, Santiago, Lumarie, Edgerton, Mary E, Rauch, Gaiane M, Giordano, Sharon H, Sahin, Aysegul, Krishnamurthy, Savitri, Woodward, Wendy, Tripathy, Debasish, Yang, Wei T, Hunt, Kelly K

“…Recent published guidelines suggest that adequate margins for DCIS should be ≥ 2 mm after breast conserving surgery followed by radiotherapy (RT). Many groups…”
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Abstract 2375: Multiclonal invasion in breast cancer identified by single cell DNA sequencing by Casasent, Anna K., Long, Annalyssa N., Schalck, Aislyn, Sei, Emi, Gao, Ruli, Davis, Alexander, Wang, Yong, Edgerton, Mary E., Navin, Nicholas E.

“…Ductal carcinoma in situ (DCIS) is the most common form of early stage breast cancer and is frequently detected by mammography. Only 10% of low-grade and 30%…”
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Significance of p63 amplification and overexpression in lung cancer development and prognosis by MASSION, Pierre P, TAFLAN, Peter M, GONZALEZ, Adriana L, JAMSHEDUR RAHMAN, S. M, YILDIZ, Pinar, SHYR, Yu, EDGERTON, Mary E, WESTFALL, Matthew D, ROBERTS, John R, PIETENPOL, Jennifer A, CARBONE, David P

“…The fight against lung cancer is greatly compromised by the lack of effective early detection strategies. Genomic abnormalities and specifically the…”
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Clinical, Histopathologic, and Immunohistochemical Features of Microglandular Adenosis and Transition Into In Situ and Invasive Carcinoma by KHALIFEH, Ibrahim M, ALBARRACIN, Constance, DIAZ, Leslie K, SYMMANS, Fraser W, EDGERTON, Mary E, HWANG, Rosa F, SNEIGE, Nour

“…Microglandular adenosis (MGA) of the breast is widely known as a benign lesion that can mimic invasive carcinoma. In situ and invasive carcinomas have been…”
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