Search Results - "EDGAR, Bruce A"

Polyploidy in tissue homeostasis and regeneration by Øvrebø, Jan Inge, Edgar, Bruce A

“…Polyploid cells, which contain multiple copies of the typically diploid genome, are widespread in plants and animals. Polyploidization can be developmentally…”
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EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors by Jiang, Huaqi, Edgar, Bruce A

“…In holometabolous insects, the adult appendages and internal organs form anew from larval progenitor cells during metamorphosis. As described here, the adult…”
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Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut by Dutta, Devanjali, Dobson, Adam J., Houtz, Philip L., Gläßer, Christine, Revah, Jonathan, Korzelius, Jerome, Patel, Parthive H., Edgar, Bruce A., Buchon, Nicolas

“…Deciphering contributions of specific cell types to organ function is experimentally challenging. The Drosophila midgut is a dynamic organ with five…”
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Fly-FUCCI: A Versatile Tool for Studying Cell Proliferation in Complex Tissues by Zielke, Norman, Korzelius, Jerome, van Straaten, Monique, Bender, Katharina, Schuhknecht, Gregor F.P., Dutta, Devanjali, Xiang, Jinyi, Edgar, Bruce A.

“…One promising approach for in vivo studies of cell proliferation is the FUCCI system (fluorescent ubiquitination-based cell cycle indicator). Here, we report…”
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EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila by Jiang, Huaqi, Grenley, Marc O., Bravo, Maria-Jose, Blumhagen, Rachel Z., Edgar, Bruce A.

“…Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or aged cells are replaced by the progeny of resident stem cells. To…”
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EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration by Xiang, Jinyi, Bandura, Jennifer, Zhang, Peng, Jin, Yinhua, Reuter, Hanna, Edgar, Bruce A.

“…Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem…”
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From Cell Structure to Transcription: Hippo Forges a New Path by Edgar, Bruce A.

“…The control of cell number during animal development is a longstanding puzzle. Recent studies in the fruit fly Drosophila melanogaster have defined a new…”
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ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration by Zhou, Jun, Edgar, Bruce A., Boutros, Michael

“…Epithelial barrier function is maintained by coordination of cell proliferation and cell loss, whereas barrier dysfunction can lead to disease and organismal…”
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Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut by Patel, Parthive H., Pénalva, Clothilde, Kardorff, Michael, Roca, Marianne, Pavlović, Bojana, Thiel, Anja, Teleman, Aurelio A., Edgar, Bruce A.

“…Epithelia are exposed to diverse types of stress and damage from pathogens and the environment, and respond by regenerating. Yet, the proximal mechanisms that…”
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An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine by Marchetti, Marco, Zhang, Chenge, Edgar, Bruce A

“…In recent years, live-imaging techniques have been developed for the adult midgut of that allow temporal characterization of key processes involved in stem…”
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EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes by Jin, Yinhua, Ha, Nati, Forés, Marta, Xiang, Jinyi, Gläßer, Christine, Maldera, Julieta, Jiménez, Gerardo, Edgar, Bruce A

“…Epithelial renewal in the Drosophila intestine is orchestrated by Intestinal Stem Cells (ISCs). Following damage or stress the intestinal epithelium produces…”
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TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease by Wang, Tao, Lao, Uyen, Edgar, Bruce A

“…Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also enhance cell death, and the TOR inhibitor rapamycin protects cells…”
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Enhanced expression of thioredoxin‐interacting‐protein regulates oxidative DNA damage and aging by Oberacker, Tina, Bajorat, Jörg, Ziola, Sabine, Schroeder, Anne, Röth, Daniel, Kastl, Lena, Edgar, Bruce A., Wagner, Wolfgang, Gülow, Karsten, Krammer, Peter H.

“…The “free radical theory of aging” suggests that reactive oxygen species (ROS) are responsible for age‐related loss of cellular functions and, therefore,…”
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In Vivo Analysis of Centromeric Proteins Reveals a Stem Cell-Specific Asymmetry and an Essential Role in Differentiated, Non-proliferating Cells by García del Arco, Ana, Edgar, Bruce A., Erhardt, Sylvia

“…Stem cells of the Drosophila midgut (ISCs) are the only mitotically dividing cells of the epithelium and, therefore, presumably the only epithelial cells that…”
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Mechanisms controlling cell cycle exit upon terminal differentiation by Buttitta, Laura A, Edgar, Bruce A

“…Coordinating terminal differentiation with permanent exit from the cell cycle is crucial for proper organogenesis, yet how the cell cycle is blocked in…”
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Inter-cell type interactions that control JNK signaling in the Drosophila intestine by Zhang, Peng, Pronovost, Stephen M., Marchetti, Marco, Zhang, Chenge, Kang, Xiaoyu, Kandelouei, Tahmineh, Li, Christopher, Edgar, Bruce A.

“…JNK signaling is a critical regulator of inflammation and regeneration, but how it is controlled in specific tissue contexts remains unclear. Here we show…”
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Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells by Korzelius, Jerome, Naumann, Svenja K, Loza-Coll, Mariano A, Chan, Jessica SK, Dutta, Devanjali, Oberheim, Jessica, Gläßer, Christine, Southall, Tony D, Brand, Andrea H, Jones, D Leanne, Edgar, Bruce A

“…Snail family transcription factors are expressed in various stem cell types, but their function in maintaining stem cell identity is unclear. In the adult…”
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Intestinal Stem Cell Pool Regulation in Drosophila by Jin, Yinhua, Patel, Parthive H., Kohlmaier, Alexander, Pavlovic, Bojana, Zhang, Chenge, Edgar, Bruce A.

“…Intestinal epithelial renewal is mediated by intestinal stem cells (ISCs) that exist in a state of neutral drift, wherein individual ISC lineages are regularly…”
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Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells by Tauc, Helen M, Rodriguez-Fernandez, Imilce A, Hackney, Jason A, Pawlak, Michal, Ronnen Oron, Tal, Korzelius, Jerome, Moussa, Hagar F, Chaudhuri, Subhra, Modrusan, Zora, Edgar, Bruce A, Jasper, Heinrich

“…Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful…”
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LST8 Regulates Cell Growth via Target-of-Rapamycin Complex 2 (TORC2) by Wang, Tao, Blumhagen, Rachel, Lao, Uyen, Kuo, Ying, Edgar, Bruce A.

“…Author's Correction ( vol. 32 , p. 3187 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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