Search Results - "EDDAHIBI, Saadia"

Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice by Savale, Laurent, Tu, Ly, Rideau, Dominique, Izziki, Mohamed, Maitre, Bernard, Adnot, Serge, Eddahibi, Saadia

“…Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated…”
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Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension by Perros, Frédéric, PhD, Ranchoux, Benoît, PhD, Izikki, Mohamed, PhD, Bentebbal, Sana, PhD, Happé, Chris, PhD, Antigny, Fabrice, PhD, Jourdon, Philippe, PhD, Dorfmüller, Peter, MD, PhD, Lecerf, Florence, MSc, Fadel, Elie, MD, Simonneau, Gerald, MD, Humbert, Marc, MD, PhD, Bogaard, Harm Jan, MD, PhD, Eddahibi, Saadia, PhD

“…Abstract Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting…”
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Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension by Gore, Benoît, Izikki, Mohamed, Mercier, Olaf, Dewachter, Laurence, Fadel, Elie, Humbert, Marc, Dartevelle, Philippe, Simonneau, Gerald, Naeije, Robert, Lebrin, Franck, Eddahibi, Saadia

“…Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients…”
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Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension by Tu, Ly, Dewachter, Laurence, Gore, Benoit, Fadel, Elie, Dartevelle, Philippe, Simonneau, Gérald, Humbert, Marc, Eddahibi, Saadia, Guignabert, Christophe

“…Pulmonary vascular remodeling is key to the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We recently reported that fibroblast growth…”
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Abnormal pulmonary endothelial cells may underlie the enigmatic pathogenesis of chronic thromboembolic pulmonary hypertension by Mercier, Olaf, MD, PhD, Ataam, Jennifer Arthur, MSc, Langer, Nathaniel B., MD, Dorfmüller, Peter, MD, PhD, Lamrani, Lilia, MSc, Lecerf, Florence, Decante, Benoit, MSc, Dartevelle, Philippe, MD, Eddahibi, Saadia, PhD, Fadel, Elie, MD, PhD

“…Background Chronic thromboembolic pulmonary hypertension results from chronic mechanical obstruction of the pulmonary arteries following acute venous…”
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Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents by Izikki, Mohamed, Guignabert, Christophe, Fadel, Elie, Humbert, Marc, Tu, Ly, Zadigue, Patricia, Dartevelle, Philippe, Simonneau, Gerald, Adnot, Serge, Maitre, Bernard, Raffestin, Bernadette, Eddahibi, Saadia

“…Pulmonary hypertension (PH) is a progressive, lethal lung disease characterized by pulmonary artery SMC (PA-SMC) hyperplasia leading to right-sided heart…”
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Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension by Perros, Frederic, Montani, David, Dorfmuller, Peter, Durand-Gasselin, Ingrid, Tcherakian, Colas, Le Pavec, Jerome, Mazmanian, Michel, Fadel, Elie, Mussot, Sacha, Mercier, Olaf, Herve, Philippe, Emilie, Dominique, Eddahibi, Saadia, Simonneau, Gerald, Souza, Rogerio, Humbert, Marc

“…Platelet-derived growth factor (PDGF) promotes the proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), and may play a role in the…”
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Role for interleukin-6 in COPD-related pulmonary hypertension by Chaouat, Ari, Savale, Laurent, Chouaid, Christos, Tu, Ly, Sztrymf, Benjamin, Canuet, Matthieu, Maitre, Bernard, Housset, Bruno, Brandt, Christian, Le Corvoisier, Philippe, Weitzenblum, Emmanuel, Eddahibi, Saadia, Adnot, Serge

“…Pulmonary artery remodeling triggered by alveolar hypoxia is considered the main mechanism of pulmonary hypertension (PH) in COPD patients. We hypothesized…”
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Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous by Perros, Frédéric, Sentenac, Pierre, Boulate, David, Manaud, Grégoire, Kotsimbos, Tom, Lecerf, Florence, Lamrani, Lilia, Fadel, Elie, Mercier, Olaf, Londono-Vallejo, Arturo, Humbert, Marc, Eddahibi, Saadia

“…Idiopathic pulmonary arterial hypertension (IPAH) is a complex disease associated with vascular remodeling and a proliferative disorder in pulmonary artery…”
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Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice by Hara, Yannis, Sassi, Yassine, Guibert, Christelle, Gambaryan, Natacha, Dorfmüller, Peter, Eddahibi, Saadia, Lompré, Anne-Marie, Humbert, Marc, Hulot, Jean-Sébastien

“…Multidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our…”
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Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension by Humbert, Marc, Montani, David, Perros, Frédéric, Dorfmüller, Peter, Adnot, Serge, Eddahibi, Saadia

“…Abstract The pathogenesis of pulmonary arterial hypertension (PAH) involves a complex and multifactorial process in which endothelial cell dysfunction appears…”
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Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats by GUIGNABERT, Christophe, RAFFESTIN, Bernadette, BENFERHAT, Rima, RAOUL, William, ZADIGUE, Patricia, RIDEAU, Dominique, HAMON, Michel, ADNOT, Serge, EDDAHIBI, Saadia

“…Progression of pulmonary hypertension (PH) is associated with increased lung expression of the serotonin transporter (5-HTT), which leads to hyperplasia of the…”
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Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats by Arthur-Ataam, Joanna, Bideaux, Patrice, Charrabi, Azzouz, Sicard, Pierre, Fromy, Bérengère, Liu, Kiaoling, Eddahibi, Saadia, Pasqualin, Côme, Jouy, Nicolas, Richard, Sylvain, Virsolvy, Anne

“…Vascular aging is characterized by increase in arterial stiffness and remodeling of the arterial wall with a loss of elastic properties. Silicon is an…”
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Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension by Guignabert, Christophe, Izikki, Mohamed, Tu, Ly Ieng, Li, Zhenlin, Zadigue, Patricia, Barlier-Mur, Anne-Marie, Hanoun, Naïma, Rodman, David, Hamon, Michel, Adnot, Serge, Eddahibi, Saadia

“…One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative…”
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Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension by Eddahibi, S, Humbert, M, Fadel, E, Raffestin, B, Darmon, M, Capron, F, Simonneau, G, Dartevelle, P, Hamon, M, Adnot, S

“…Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of primary pulmonary hypertension (PPH). Here we found that…”
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Apoptosis and Effects of Intracavernous Bone Marrow Cell Injection in a Rat Model of Postprostatectomy Erectile Dysfunction by Fall, Papa Ahmed, Izikki, Mohamed, Tu, Li, Swieb, Salem, Giuliano, Francois, Bernabe, Jacques, Souktani, Rachid, Abbou, Claude, Adnot, Serge, Eddahibi, Saadia, Yiou, René

“…Abstract Objectives To investigate the pathophysiology of postprostatectomy erectile dysfunction (pPED) in a rat model of bilateral cavernous nerve ablation…”
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Pulmonary microvascular lesions regress in reperfused chronic thromboembolic pulmonary hypertension by Boulate, David, MD, MSc, Perros, Fréderic, PhD, Dorfmuller, Peter, MD, PhD, Arthur-Ataam, Jennifer, MSc, Guihaire, Julien, MD, MSc, Lamrani, Lilia, MSc, Decante, Benoit, MSc, Humbert, Marc, MD, PhD, Eddahibi, Saadia, PhD, Dartevelle, Philippe, MD, Fadel, Elie, MD, PhD, Mercier, Olaf, MD, PhD

“…Background Pulmonary microvascular disease (PMD) develops in both occluded and non-occluded territories in patients with chronic thromboembolic pulmonary…”
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Serotonin-Induced Smooth Muscle Hyperplasia in Various Forms of Human Pulmonary Hypertension by Marcos, Elisabeth, Fadel, Elie, Sanchez, Olivier, Humbert, Marc, Dartevelle, Philippe, Simonneau, Gerald, Hamon, Michel, Adnot, Serge, Eddahibi, Saadia

“…Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of pulmonary hypertension (PH). Serotonin (5-HT) is involved…”
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Angiopoietin/Tie2 Pathway Influences Smooth Muscle Hyperplasia in Idiopathic Pulmonary Hypertension by Dewachter, Laurence, Adnot, Serge, Fadel, Elie, Humbert, Marc, Maitre, Bernard, Barlier-Mur, Anne-Marie, Simonneau, Gerald, Hamon, Michel, Naeije, Robert, Eddahibi, Saadia

“…Angiopoietins are involved in blood vessel maturation and remodeling. One consequence of endothelium-specific tyrosine kinase-2 (Tie2) receptor activation by…”
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Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease by EDDAHIBI, Saadia, CHAOUAT, Ari, ADNOT, Serge, MORRELL, Nicholas, FADEL, Elie, FUHRMAN, Claire, BUGNET, Anne-Sophie, DARTEVELLE, Philippe, HOUSSET, Bruno, HAMON, Michel, WEITZENBLUM, E

“…The serotonin transporter (5-HTT) is involved in the pulmonary artery smooth muscle hyperplasia that leads to pulmonary hypertension (PH). Because hypoxia and…”
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