Search Results - "ECKSTEIN, James A"

INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450 by FAYER REHMEL, Jessica L, ECKSTEIN, James A, FARID, Nagy A, HEIM, John B, KASPER, Steve C, KURIHARA, Atsushi, WRIGHTON, Steven A, RING, Barbara J

“…The biotransformation of prasugrel to R-138727 (2-[1-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic acid) involves rapid…”
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An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes by SOARS, Matthew G, PETULLO, David M, ECKSTEIN, James A, KASPER, Steve C, WRIGHTON, Steven A

“…Uridine diphosphate glucuronosyltransferases (UGTs) catalyze the glucuronidation of a wide range of xenobiotics and endogenous substrates. However, there is a…”
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Identification of the Human Cytochromes P450 Responsible for Atomoxetine Metabolism by RING, Barbara J, GILLESPIE, Jennifer S, ECKSTEIN, James A, WRIGHTON, Steven A

“…Studies were performed to determine the human enzymes responsible for the biotransformation of atomoxetine to its major metabolite, 4-hydroxyatomoxetine, and…”
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Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation by Ackermann, Bradley L, Berna, Michael J, Eckstein, James A, Ott, Lee W, Chaudhary, Ajai K

“…Current drug discovery involves a highly iterative process pertaining to three core disciplines: biology, chemistry, and drug disposition. For most…”
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Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules by Jones, Barry R, Schultz, Gary A, Eckstein, James A, Ackermann, Bradley L

“…Quantitation of biomarkers by LC-MS/MS is complicated by the presence of endogenous analytes. This challenge is most commonly overcome by calibration using an…”
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Analysis of glutamine, glutamate, pyroglutamate, and GABA in cerebrospinal fluid using ion pairing HPLC with positive electrospray LC/MS/MS by Eckstein, James A., Ammerman, Gina M., Reveles, Jessica M., Ackermann, Bradley L.

“…A simple and sensitive method for the separation and quantitation of glutamine, glutamate, pyroglutamate, and γ-aminobutyric acid (GABA) in cerebrospinal fluid…”
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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes by Fell, Matthew J, Witkin, Jeffrey M, Falcone, Julie F, Katner, Jason S, Perry, Kenneth W, Hart, John, Rorick-Kehn, Linda, Overshiner, Carl D, Rasmussen, Kurt, Chaney, Stephen F, Benvenga, Mark J, Li, Xia, Marlow, Deanna L, Thompson, Linda K, Luecke, Susan K, Wafford, Keith A, Seidel, Wesley F, Edgar, Dale M, Quets, Anne T, Felder, Christian C, Wang, XuShan, Heinz, Beverly A, Nikolayev, Alexander, Kuo, Ming-Shang, Mayhugh, Daniel, Khilevich, Albert, Zhang, Deyi, Ebert, Philip J, Eckstein, James A, Ackermann, Bradley L, Swanson, Steven P, Catlow, John T, Dean, Robert A, Jackson, Kimberley, Tauscher-Wisniewski, Sitra, Marek, Gerard J, Schkeryantz, Jeffrey M, Svensson, Kjell A

“…The normalization of excessive glutamatergic neurotransmission through the activation of metabotropic glutamate 2 (mGlu2) receptors may have therapeutic…”
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Simultaneous profiling of multiple neurochemical pathways from a single cerebrospinal fluid sample using GC/MS/MS with electron capture detection by Eckstein, James A, Ammerman, Gina M, Reveles, Jessica M, Ackermann, Bradley L

“…Biogenic amines and amino acids are widely characterized in the pathways representing neurotransmission. Although several analytical methodologies have been…”
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Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine by Ring, B J, Eckstein, J A, Gillespie, J S, Binkley, S N, VandenBranden, M, Wrighton, S A

“…The formation of R- and S-norfluoxetine was analyzed in vitro in human liver microsomes. Low apparent K(m) values for R-norfluoxetine formation of < or =8…”
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Cloning and sequencing of the Candida albicans C-4 sterol methyl oxidase gene (ERG25) and expression of an ERG25 conditional lethal mutation in Saccharomyces cerevisiae by Kennedy, M.A, Johnson, T.A, Lees, N.D, Barbuch, R, Eckstein, J.A, Bard, M

“…The ERG25 gene encoding the Candida albicans C‐4 sterol methyl oxidase was cloned and sequenced by complementing a Saccharomyces cerevisiae erg25 mutant with a…”
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Determination of a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist (LY300164) and its N-acetyl metabolite in mouse, rat, dog, and monkey plasma using high-performance liquid chromatography with ultraviolet detection by Eckstein, James A., Swanson, Steven P.

“…A method for the analysis of the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptor antagonist LY300164 (compound I) and its N-acetyl metabolite…”
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Determination of dolasetron and its reduced metabolite in human plasma by GC-MS and LC by Gillespie, T A, Eckstein, J A, Nardella, P, Coutant, J E

“…Both a GC-MS and an LC method have been developed for the simultaneous quantitation of dolasetron and reduced dolasetron in human plasma. The GC-MS method has…”
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