Search Results - "ECKHART, Andrea D"

Regulation of GPCR signaling in Hypertension by Brinks, Henriette L., Eckhart, Andrea D.

“…Hypertension represents a complex, multifactorial disease and contributes to the major causes of morbidity and mortality in industrialized countries: ischemic…”
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G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure by Raake, Philip W, Vinge, Leif E, Gao, Erhe, Boucher, Matthieu, Rengo, Giuseppe, Chen, Xiongwen, DeGeorge, Brent R, Matkovich, Scot, Houser, Steven R, Most, Patrick, Eckhart, Andrea D, Dorn, Gerald W, Koch, Walter J

“…Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac β-adrenergic receptor (βAR) signaling and cardiac function. Its…”
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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent Jr, Chuprun, J. Kurt, Harris, David M, Gao, Erhe, Eckhart, Andrea D, Pitcher, Julie A, Koch, Walter J

“…G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs…”
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Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms by Brinks, Henriette, Boucher, Matthieu, Gao, Erhe, Chuprun, J Kurt, Pesant, Stéphanie, Raake, Philip W, Huang, Z Maggie, Wang, Xiaoliang, Qiu, Gang, Gumpert, Anna, Harris, David M, Eckhart, Andrea D, Most, Patrick, Koch, Walter J

“…RATIONALE:Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein–coupled receptors (GPCRs) protects myocardium in…”
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Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells by Mahadev, Kalyankar, Wu, Xiangdong, Donnelly, Sylvia, Ouedraogo, Raogo, Eckhart, Andrea D., Goldstein, Barry J.

“…Aims Vascular endothelial growth factor (VEGF)-induced endothelial cell migration and angiogenesis are associated with the vascular complications of diabetes…”
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Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy by Chen, Xiongwen, Nakayama, Hiroyuki, Zhang, Xiaoying, Ai, Xiaojie, Harris, David M, Tang, Mingxin, Zhang, Hongyu, Szeto, Christopher, Stockbower, Kathryn, Berretta, Remus M, Eckhart, Andrea D, Koch, Walter J, Molkentin, Jeffery D, Houser, Steven R

“…Abstract Pathological cardiac hypertrophy (PCH) is associated with the development of arrhythmia and congestive heart failure. While calcium (Ca2+ ) is…”
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S100A1 Genetically Targeted Therapy Reverses Dysfunction of Human Failing Cardiomyocytes by Brinks, Henriette, MD, Rohde, David, MD, Voelkers, Mirko, MD, Qiu, Gang, MD, Pleger, Sven T., MD, Herzog, Nicole, MS, Rabinowitz, Joseph, PhD, Ruhparwar, Arjang, MD, Silvestry, Scott, MD, Lerchenmüller, Carolin, MD, Mather, Paul J., MD, Eckhart, Andrea D., PhD, Katus, Hugo A., MD, Carrel, Thierry, MD, Koch, Walter J., PhD, Most, Patrick, MD

“…Objectives This study investigated the hypothesis whether S100A1 gene therapy can improve pathological key features in human failing ventricular cardiomyocytes…”
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Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue by PLEGER, Sven T, MOST, Patrick, KATUS, Hugo A, ECKHART, Andrea D, RABINOWITZ, Joseph E, KOCH, Walter J, BOUCHER, Matthieu, SOLTYS, Stephen, KURT CHUPRUN, J, PLEGER, Wiebke, ERHE GAO, DASGUPTA, Abhijit, RENGO, Giuseppe, REMPPIS, Andrew

“…The incidence of heart failure is ever-growing, and it is urgent to develop improved treatments. An attractive approach is gene therapy; however, the clinical…”
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Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction by MOST, Patrick, SEIFERT, Hanna, FELDMAN, Arthur M, KOCH, Walter J, ERHE GAO, FUNAKOSHI, Hajime, VÖLKERS, Mirko, HEIERHORST, Jörg, REMPPIS, Andrew, PLEGER, Sven T, DEGEORGE, Brent R, ECKHART, Andrea D

“…Diminished cardiac S100A1 protein levels are characteristic of ischemic and dilated human cardiomyopathy. Because S100A1 has recently been identified as a…”
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GPCR signalling in hypertension: role of GRKs by Harris, David M, Cohn, Heather I, Pesant, Stéphanie, Eckhart, Andrea D

“…Hypertension is a prevalent condition in the developed world and disease severity is directly correlated with additional cardiovascular complications. It is…”
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Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress by DEGEORGE, Brent R, ERHE GAO, ECKHART, Andrea D, KOCH, Walter J, BOUCHER, Matthieu, VINGE, Leif E, MARTINI, Jeffrey S, RAAKE, Philip W, CHUPRUN, J. Kurt, HARRIS, David M, KIM, Gilbert W, SOLTYS, Stephen

“…A salient characteristic of dysfunctional myocardium progressing to heart failure is an upregulation of the adenylyl cyclase inhibitory guanine nucleotide (G)…”
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Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart by Gao, Erhe, Boucher, Matthieu, Chuprun, J Kurt, Zhou, Rui-Hai, Eckhart, Andrea D, Koch, Walter J

“…Recent studies from our lab and others have shown that the hematopoietic cytokine erythropoietin (EPO) can protect the heart from ischemic damage in a red…”
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G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor by Mifune, Mizuo, Ohtsu, Haruhiko, Suzuki, Hiroyuki, Nakashima, Hidekatsu, Brailoiu, Eugen, Dun, Nae J., Frank, Gerald D., Inagami, Tadashi, Higashiyama, Shigeki, Thomas, Walter G., Eckhart, Andrea D., Dempsey, Peter J., Eguchi, Satoru

“…A G protein-coupled receptor agonist, angiotensin II (AngII), induces epidermal growth factor (EGF) receptor (EGFR) transactivation possibly through…”
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Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia by Giangrande, Paloma H, Zhang, JianXin, Tanner, Alice, Eckhart, Andrea D, Rempel, Rachel E, Andrechek, Eran R, Layzer, Juliana M, Keys, Janelle R, Hagen, Per-Otto, Nevins, Joseph R, Koch, Walter J, Sullenger, Bruce A

“…Intimal hyperplasia (IH) and restenosis limit the long-term utility of bypass surgery and angioplasty due to pathological proliferation and migration of…”
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Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism by Miller, Marcus J., Kennedy, Adam D., Eckhart, Andrea D., Burrage, Lindsay C., Wulff, Jacob E., Miller, Luke A.D., Milburn, Michael V., Ryals, John A., Beaudet, Arthur L., Sun, Qin, Sutton, V. Reid, Elsea, Sarah H.

“…Global metabolic profiling currently achievable by untargeted mass spectrometry-based metabolomic platforms has great potential to advance our understanding of…”
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Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure by Koch, Walter J, Lymperopoulos, Anastasios, Rengo, Giuseppe, Funakoshi, Hajime, Eckhart, Andrea D

“…Cardiac overstimulation by the sympathetic nervous system (SNS) is a salient characteristic of heart failure, reflected by elevated circulating levels of…”
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Myocardial gene transfer and overexpression of β2-Adrenergic receptors potentiates the functional recovery of unloaded failing hearts by TEVAEARAI, Hendrik T, ECKHART, Andrea D, WALTON, G. Brant, KEYS, Janelle R, WILSON, Katrina, KOCH, Walter J

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Gq-Coupled Receptor Agonists Mediate Cardiac Hypertrophy Via the Vasculature by Keys, Janelle R, Greene, Emily A, Koch, Walter J, Eckhart, Andrea D

“…ABSTRACT—The Gq-coupled receptor-signaling pathway has been implicated in the cardiac hypertrophic response to stress, but little is actually known about the…”
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Metabolomics as a Key Integrator for "Omic" Advancement of Personalized Medicine and Future Therapies by Eckhart, Andrea D., Beebe, Kirk, Milburn, Mike

“…Investigation into biological complexity, whether for a better understanding of disease or drug process, is a monumental task plaguing investigators. The lure…”
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Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart by Eckhart, Andrea D, Duncan, Sandra J, Penn, Raymond B, Benovic, Jeffrey L, Lefkowitz, Robert J, Koch, Walter J

“…G protein–coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including α1B-adrenergic receptors (ARs), resulting in…”
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