Search Results - "ECKERT, H. G"

Influence of multiplicity of infection and protein stability on retroviral vector-mediated gene expression in hematopoietic cells by WAHLERS, A, SCHWIEGER, M, LI, Z, MEIER-TACKMANN, D, LINDEMANN, C, ECKERT, H.-G, VON LAER, D, BAUM, C

“…Using retroviral vectors encoding enhanced green fluorescent protein (EGFP), we addressed to what extent expression of retroviral transgenes in hematopoietic…”
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Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice by Schiedlmeier, B., Kühlcke, K., Eckert, H.G., Baum, C., Zeller, W.J., Fruehauf, S.

“…Mobilized peripheral blood progenitor cells (PBPC) are a potential target for the retrovirus-mediated transfer of cytostatic drug-resistance genes. We analyzed…”
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Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells by Baum, C, Hegewisch-Becker, S, Eckert, H G, Stocking, C, Ostertag, W

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Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells by KNIPPER, R, KUEHLCKE, K, ECKERT, H.-G, BAUM, C, SCHIEDLMEIER, B, HILDINGER, M, LINDEMANN, C, SCHILZ, A. J, FAUSER, A. A, FRUEHAUF, S, ZELLER, W. J, OSTERTAG, W

“…We describe the functional analysis of a novel retroviral vector, SF91m3, which was designed for improved expression of the in vivo selectable marker,…”
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FMEV vectors : both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells by HILDINGER, M, ECKERT, H.-G, SCHILZ, A. T, JOHN, T, OSTERTAG, W, BAUM, C

“…FMEV retroviral vectors combine the long terminal repeat of Friend mink cell focus-forming viruses with the 5' untranslated leader region of the murine…”
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MDR1 Gene Expression in NOD/SCID Repopulating Cells after Retroviral Gene Transfer under Clinically Relevant Conditions by Schilz, A.J., Schiedlmeier, B., Kühlcke, K., Fruehauf, S., Lindemann, C., Zeller, W.J., Grez, M., Fauser, A.A., Baum, C., Eckert, H.-G.

“…We have adapted a recently published protocol for retroviral gene transfer into hematopoietic cells [A. J. Schilz et al. (1998) Blood 92: 3163–3171] with…”
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Clinical scale production of an improved retroviral vector expressing the human multidrug resistance 1 gene (MDR1) by Eckert, H G, Kühlcke, K, Schilz, A J, Lindemann, C, Basara, N, Fauser, A A, Baum, C

“…Retroviral vectors are currently the most important and best characterized tools for ex vivo genetic modification of hematopoietic progenitor/stem cells. As a…”
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Establishment of an optimised gene transfer protocol for human primary T lymphocytes according to clinical requirements by AYUK, F. A, LI, Z, KÜHLCKE, K, LINDEMANN, C, SCHADE, U. M, ECKERT, H.-G, ZANDER, A. R, FEHSE, B

“…Current gene therapeutic protocols directed towards the treatment of inherited disorders (eg ADA-SCID) and viral infections (eg AIDS), as well as adoptive…”
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Bicistronic retroviral vectors for combining myeloprotection with cell-surface marking by HILDINGER, M, SCHILZ, A, ECKERT, H.-G, BOHN, W, FEHSE, B, ZANDER, A. R, OSTERTAG, W, BAUM, C

“…We have developed a retroviral vector coexpressing the multidrug-resistance 1 (MDR1) cDNA for inducing cancer drug resistance and the truncated version of the…”
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Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas by Baum, C, Peinert, S, Carpinteiro, A, Eckert, H G, Fairbairn, L J

“…Genetic transfer and expression of drug-resistance functions into haematopoietic stem and progenitor cells is a promising means to overcome both the acute and…”
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Retroviral transduction of T lymphocytes for suicide gene therapy in allogeneic stem cell transplantation by Kühlcke, K, Ayuk, F A, Li, Z, Lindemann, C, Schilz, A, Schade, U M, Fauser, A A, Zander, A R, Eckert, H G, Fehse, B

“…Transplantation of suicide gene modified allogeneic T lymphocytes is an approach to prevent T cell mediated GVHD while preserving the 'graft-versus-leukemia'…”
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The effects of dose, route of administration, drug scheduling and MDR-1 gene transfer on the genotoxicity of etoposide in bone marrow by TURNER, S. D, RAFFERTY, J. A, FAIRBAIRN, L. J, ASHBY, J, TINWELL, H, ECKERT, H-G, BAUM, C, LASHFORD, L. S

“…We have used the bone marrow micronucleus assay (BMMN) as a measure of clastogenicity, in response to etoposide exposure in murine bone marrow. Oral delivery…”
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Murine Leukemia Induced by Retroviral Gene Marking by Li, Zhixiong, Düllmann, Jochen, Schiedlmeier, Bernd, Schmidt, Manfred, von Kalle, Christof, Meyer, Johann, Forster, Martin, Stocking, Carol, Wahlers, Anke, Frank, Oliver, Ostertag, Wolfram, Kühlcke, Klaus, Eckert, Hans-Georg, Fehse, Boris, Baum, Christopher

“…Using a replication-defective vector, the authors introduced the clinically used dLNGFR marker gene into murine bone marrow cells before transplantation into…”
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High-Dose Multidrug Resistance in Primary Human Hematopoietic Progenitor Cells Transduced With Optimized Retroviral Vectors by Eckert, Hans-Georg, Stockschläder, Marcus, Just, Ursula, Hegewisch-Becker, Susanna, Grez, Manuel, Uhde, Almut, Zander, Axel, Ostertag, Wolfram, Baum, Christopher

“…Retroviral transfer of the multidrug-resistance 1 (mdr1) cDNA into primary human hematopoietic progenitor cells (HPC) of cancer patients undergoing high-dose…”
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Optimization of retroviral vector generation for clinical application by Schilz, Andrea J., Kühlcke, Klaus, Fauser, Axel A., Eckert, Hans-Georg

“…Background For many inherited and acquired diseases of the blood system, gene transfer into hematopoietic cells is a promising strategy to alleviate…”
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Gene transfer to augment the therapeutic index of anticancer chemotherapy by Baum, C, Margison, G P, Eckert, H G, Fairbairn, L J, Ostertag, W, Rafferty, J A

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Human multidrug resistance-1 gene transfer to long-term repopulating human mobilized peripheral blood progenitor cells by Schiedlmeier, B, Wermann, K, Kühlcke, K, Eckert, H G, Baum, C, Fruehauf, S, Zeller, W J

“…Mobilized peripheral blood progenitor cells (PBPC) are an attractive target for the retrovirus-mediated transfer of cytostatic drug resistance genes. We…”
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cis-Active elements of Friend spleen focus-forming virus: from disease induction to disease prevention by Baum, C, Hunt, N, Hildinger, M, Eckert, H G, Zaehres, H, Richters, A, John, J, Löhler, J, Ostertag, W

“…The polycythemic strain of the Friend spleen focus-forming virus (SFFVp) is a replication-defective, acutely transforming retrovirus inducing a bistage…”
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Lack of interaction between ramipril and simvastatin by MEYER, B. H, SCHOLTZ, H. E.K, MÜLLER, F. O, LUUS, H. G, DE LA REY, N, SEIBERT-GRAFE, M, ECKERT, H. G, METZGER, H

“…Twenty two healthy males participated in a randomised, placebo-controlled, double blind, cross-over study to investigate the influence of simvastatin on the…”
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Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice by Schiedlmeier, Bernd, Schilz, Andrea J, Kühlcke, Klaus, Laufs, Stephanie, Baum, Christopher, Zeller, W Jens, Eckert, Hans-Georg, Fruehauf, Stefan

“…Myelosuppression is the main side effect of cancer chemotherapy. An improved rate of retroviral vector-mediated gene transfer to hematopoietic stem cells,…”
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