Search Results - "ECKERT, Debra M"

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission by Koirala, Sajjan, Guo, Qian, Kalia, Raghav, Bui, Huyen T, Eckert, Debra M, Frost, Adam, Shaw, Janet M

“…Mitochondrial fission is mediated by the dynamin-related GTPases Dnm1/Drp1 (yeast/mammals), which form spirals around constricted sites on mitochondria…”
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Homogeneous surrogate virus neutralization assay to rapidly assess neutralization activity of anti-SARS-CoV-2 antibodies by Kim, Sun Jin, Yao, Zhong, Marsh, Morgan C., Eckert, Debra M., Kay, Michael S., Lyakisheva, Anna, Pasic, Maria, Bansal, Aiyush, Birnboim, Chaim, Jha, Prabhat, Galipeau, Yannick, Langlois, Marc-André, Delgado, Julio C., Elgort, Marc G., Campbell, Robert A., Middleton, Elizabeth A., Stagljar, Igor, Owen, Shawn C.

“…The COVID-19 pandemic triggered the development of numerous diagnostic tools to monitor infection and to determine immune response. Although assays to measure…”
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Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA by Consalvo, Claudia D, Aderounmu, Adedeji M, Donelick, Helen M, Aruscavage, P Joseph, Eckert, Debra M, Shen, Peter S, Bass, Brenda L

“…Invertebrates use the endoribonuclease Dicer to cleave viral dsRNA during antiviral defense, while vertebrates use RIG-I-like Receptors (RLRs), which bind…”
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Structural basis for ESCRT-III protein autoinhibition by Langelier, Charles, Hill, Christopher P, Uter, Nathan T, McCullough, John, Sundquist, Wesley I, Schubert, Heidi L, Bajorek, Monika, Myszka, David G, Eckert, Debra M, Stubblefield, William-May B

“…ESCRT-III proteins play important roles in multivesicular body (MVB) formation, cytokinesis, and enveloped virus budding. The structure of Ist1, which also…”
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MECHANISMS OF VIRAL MEMBRANE FUSION AND ITS INHIBITION by Eckert, Debra M, Kim, Peter S

“…Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical…”
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Design of a Potent d-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance by WELCH, Brett D, FRANCIS, J. Nicholas, ROOT, Michael J, KAY, Michael S, REDMAN, Joseph S, PAUL, Suparna, WEINSTOCK, Matthew T, REEVES, Jacqueline D, LIE, Yolanda S, WHITBY, Frank G, ECKERT, Debra M, HILL, Christopher P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mechanistic and structural studies reveal NRAP-1-dependent coincident activation of NMDARs by Goodell, Dayton J., Whitby, Frank G., Mellem, Jerry E., Lei, Ning, Brockie, Penelope J., Maricq, Aleksander J., Eckert, Debra M., Hill, Christopher P., Madsen, David M., Maricq, Andres V.

“…N-methyl-D-aspartate (NMDA)-type ionotropic glutamate receptors have essential roles in neurotransmission and synaptic plasticity. Previously, we identified an…”
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Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag by Fulcher, James M, Petersen, Mark E, Giesler, Riley J, Cruz, Zachary S, Eckert, Debra M, Francis, J Nicholas, Kawamoto, Eric M, Jacobsen, Michael T, Kay, Michael S

“…The application of solid-phase peptide synthesis and native chemical ligation in chemical protein synthesis (CPS) has enabled access to synthetic proteins that…”
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The Oligomeric State of the Active Vps4 AAA ATPase by Monroe, Nicole, Han, Han, Gonciarz, Malgorzata D., Eckert, Debra M., Karren, Mary Anne, Whitby, Frank G., Sundquist, Wesley I., Hill, Christopher P.

“…The cellular ESCRT (endosomal sorting complexes required for transport) pathway drives membrane constriction toward the cytosol and effects membrane fission…”
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Virion stiffness regulates immature HIV-1 entry by Pang, Hong-Bo, Hevroni, Liron, Kol, Nitzan, Eckert, Debra M, Tsvitov, Marianna, Kay, Michael S, Rousso, Itay

“…Human immunodeficiency virus type 1 (HIV-1) undergoes a protease-mediated maturation process that is required for its infectivity. Little is known about how…”
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Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations by Schubert, Heidi L., Zhai, Qianting, Sandrin, Virginie, Eckert, Debra M., Garcia-Maya, Mitla, Saul, Louise, Sundquist, Wesley I., Steiner, Roberto A., Hill, Christopher P., Harrison, Stephen C.

“…HIV-1 and other enveloped viruses can be restricted by a host cellular protein called BST2/tetherin that prevents release of budded viruses from the cell…”
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A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins by Khan, Danish, Lee, Dongju, Gulten, Gulcin, Aggarwal, Anup, Wofford, Joshua, Krieger, Inna, Tripathi, Ashutosh, Patrick, John W, Eckert, Debra M, Laganowsky, Arthur, Sacchettini, James, Lindahl, Paul, Bankaitis, Vytas A

“…Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer…”
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Cyclic Tetra-Adenylate (cA 4 ) Recognition by Csa3; Implications for an Integrated Class 1 CRISPR-Cas Immune Response in Saccharolobus solfataricus by Charbonneau, Alexander A, Eckert, Debra M, Gauvin, Colin C, Lintner, Nathanael G, Lawrence, C Martin

“…Csa3 family transcription factors are ancillary CRISPR-associated proteins composed of N-terminal CARF domains and C-terminal winged helix-turn-helix domains…”
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Characterization of resistance to a potent D-peptide HIV entry inhibitor by Smith, Amanda R, Weinstock, Matthew T, Siglin, Amanda E, Whitby, Frank G, Francis, J Nicholas, Hill, Christopher P, Eckert, Debra M, Root, Michael J, Kay, Michael S

“…PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved…”
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Design of Potent Inhibitors of HIV-1 Entry from the gp41 N-Peptide Region by Eckert, Debra M., Kim, Peter S.

“…The HIV-1 gp41 envelope glycoprotein promotes fusion of the virus and cell membranes through the formation of a trimer-of-hairpins structure, in which the…”
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Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes by Koirala, Sajjan, Bui, Huyen T, Schubert, Heidi L, Eckert, Debra M, Hill, Christopher P, Kay, Michael S, Shaw, Janet M

“…Recruitment and assembly of some dynamin-related guanosine triphosphatases depends on adaptor proteins restricted to distinct cellular membranes. The yeast…”
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RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA by Parker, Greg S, Eckert, Debra M, Bass, Brenda L

“…In organisms ranging from Arabidopsis to humans, Dicer requires dsRNA-binding proteins (dsRBPs) to carry out its roles in RNA interference (RNAi) and micro-RNA…”
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A Human Monoclonal Antibody Neutralizes Diverse HIV-1 Isolates by Binding a Critical gp41 Epitope by Miller, Michael D., Geleziunas, Romas, Bianchi, Elisabetta, Simon Lennard, Hrin, Renee, Hangchun Zhang, Lu, Meiqing, An, Zhiqiang, Ingallinella, Paolo, Finotto, Marco, Marco Mattu, Adam C. Finnefrock, Bramhill, David, Cook, James, Eckert, Debra M., Hampton, Richard, Patel, Mayuri, Stephen Jarantow, Joseph Joyce, Ciliberto, Gennaro, Cortese, Riccardo, Lu, Ping, William Strohl, Schleif, William, Michael Mc Elhaugh, Lane, Steven, Lloyd, Christopher, Lowe, David, Jane Osbourn, Tristan Vaughan, Emini, Emilio, Gaetano Barbato, Kim, Peter S., Hazuda, Daria J., Shiver, John W., Pessi, Antonello

“…HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat…”
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Stalking influenza by Eckert, Debra M, Kay, Michael S

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Biochemical and Structural Studies of Yeast Vps4 Oligomerization by Gonciarz, Malgorzata D., Whitby, Frank G., Eckert, Debra M., Kieffer, Collin, Heroux, Annie, Sundquist, Wesley I., Hill, Christopher P.

“…The ESCRT (endosomal sorting complexes required for transport) pathway functions in vesicle formation at the multivesicular body, the budding of enveloped RNA…”
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