Search Results - "ECKERT, Danny J"

Phenotypic approaches to obstructive sleep apnoea – New pathways for targeted therapy by Eckert, Danny J

“…Summary People develop obstructive sleep apnoea (OSA) for different reasons. The ability to understand these reasons, easily identify them in individual…”
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Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment by Eckert, Danny J, Younes, Magdy K

“…Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally important in restoring airflow and blood-gas disturbances at the…”
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Defining Phenotypic Causes of Obstructive Sleep Apnea: Identification of Novel Therapeutic Targets by ECKERT, Danny J, WHITE, David P, JORDAN, Amy S, MALHOTRA, Atul, WELLMAN, Andrew

“…The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among patients but have not been well characterized. To define carefully the…”
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The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial by Taranto-Montemurro, Luigi, Messineo, Ludovico, Sands, Scott A, Azarbarzin, Ali, Marques, Melania, Edwards, Bradley A, Eckert, Danny J, White, David P, Wellman, Andrew

“…There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and…”
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Bi-directional relationships between co-morbid insomnia and sleep apnea (COMISA) by Sweetman, Alexander, Lack, Leon, McEvoy, R Doug, Smith, Simon, Eckert, Danny J., Osman, Amal, Carberry, Jayne C., Wallace, Douglas, Nguyen, Phuc D., Catcheside, Peter

“…Insomnia and obstructive sleep apnea (OSA) commonly co-occur. Approximately 30–50% of patients with OSA report clinically significant insomnia symptoms, and…”
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Obstructive Sleep Apnea without Obesity Is Common and Difficult to Treat: Evidence for a Distinct Pathophysiological Phenotype by Gray, Emma L, McKenzie, David K, Eckert, Danny J

“…To determine the proportion and physiological characteristics of nonobese patients with obstructive sleep apnea (OSA) and their response to prescribed therapy…”
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Arousal Intensity is a Distinct Pathophysiological Trait in Obstructive Sleep Apnea by Amatoury, Jason, Azarbarzin, Ali, Younes, Magdy, Jordan, Amy S., Wellman, Andrew, Eckert, Danny J.

“…Abstract Study Objectives: Arousals from sleep vary in duration and intensity. Accordingly, the physiological consequences of different types of arousals may…”
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Obstructive sleep apnea in older adults is a distinctly different physiological phenotype by Edwards, Bradley A, Wellman, Andrew, Sands, Scott A, Owens, Robert L, Eckert, Danny J, White, David P, Malhotra, Atul

“…Current evidence suggests that the pathological mechanisms underlying obstructive sleep apnea (OSA) are altered with age. However, previous studies examining…”
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Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold by Eckert, Danny J, Owens, Robert L, Kehlmann, Geoffrey B, Wellman, Andrew, Rahangdale, Shilpa, Yim-Yeh, Susie, White, David P, Malhotra, Atul

“…Recent insights into sleep apnoea pathogenesis reveal that a low respiratory arousal threshold (awaken easily) is important for many patients. As most patients…”
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The effects of zolpidem in obstructive sleep apnea – An open‐label pilot study by Carberry, Jayne C., Grunstein, Ronald R., Eckert, Danny J.

“…New knowledge on hypnotics and their effects on the phenotypic causes of obstructive sleep apnea indicate that zolpidem has therapeutic potential for certain…”
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New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences by Lechat, Bastien, Scott, Hannah, Naik, Ganesh, Hansen, Kristy, Nguyen, Duc Phuc, Vakulin, Andrew, Catcheside, Peter, Eckert, Danny J

“…Current approaches to quantify and diagnose sleep disorders and circadian rhythm disruption are imprecise, laborious, and often do not relate well to key…”
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A method for measuring and modeling the physiological traits causing obstructive sleep apnea by WELLMAN, Andrew, ECKERT, Danny J, JORDAN, Amy S, EDWARDS, Bradley A, PASSAGLIA, Chris L, JACKSON, Andrew C, GAUTAM, Shiva, OWENS, Robert L, MALHOTRA, Atul, WHITE, David P

“…There is not a clinically available technique for measuring the physiological traits causing obstructive sleep apnea (OSA). Therefore, it is often difficult to…”
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An automated and reliable method for breath detection during variable mask pressures in awake and sleeping humans by Nguyen, Chinh D, Amatoury, Jason, Carberry, Jayne C, Eckert, Danny J

“…Accurate breath detection is crucial in sleep and respiratory physiology research and in several clinical settings. However, this process is technically…”
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Sleep-Disordered Breathing in People with Multiple Sclerosis: Prevalence, Pathophysiological Mechanisms, and Disease Consequences by Hensen, Hanna A, Krishnan, Arun V, Eckert, Danny J

“…Sleep problems are common in people with multiple sclerosis (MS). Reported prevalence rates of sleep-disordered breathing (SDB) vary between 0 and 87%…”
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Extended-Release Morphine for Chronic Breathlessness in Pulmonary Arterial Hypertension—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study by Ferreira, Diana H., Ekström, Magnus, Sajkov, Dimitar, Vandersman, Zac, Eckert, Danny J., Currow, David C.

“…Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with…”
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Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea by ECKERT, Danny J, LO, Yu L, SABOISKY, Julian P, JORDAN, Amy S, WHITE, David P, MALHOTRA, Atul

“…Numerous studies have demonstrated upper-airway neuromuscular abnormalities during wakefulness in snorers and obstructive sleep apnea (OSA) patients. However,…”
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Airway Dilator Muscle Activity and Lung Volume During Stable Breathing in Obstructive Sleep Apnea by JORDAN, Amy S, WHITE, David P, LO, Yu-Lun, WELLMAN, Andrew, ECKERT, Danny J, YIM-YEH, Susie, EIKERMANN, Matthias, SMITH, Scott A, STEVENSON, Karen E, MALHOTRA, Atul

“…Many patients with obstructive sleep apnea (OSA) have spontaneous periods of stable flow limited breathing during sleep without respiratory events or arousals…”
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Chronic breathlessness and sleep problems: a population-based survey by Currow, David C, Chang, Sungwon, Ferreira, Diana, Eckert, Danny J, Gonzalez-Chica, David, Stocks, Nigel, Ekström, Magnus Per

“…ObjectivesThis study aimed to explore the relationship (presence and severity) between chronic breathlessness and sleep problems, independently of diagnoses…”
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Association Between Sleep Microstructure and Incident Hypertension in a Population-Based Sample: The HypnoLaus Study by Berger, Mathieu, Vakulin, Andrew, Hirotsu, Camila, Marchi, Nicola Andrea, Solelhac, Geoffroy, Bayon, Virginie, Siclari, Francesca, Haba-Rubio, José, Vaucher, Julien, Vollenweider, Peter, Marques-Vidal, Pedro, Lechat, Bastien, Catcheside, Peter G, Eckert, Danny J, Adams, Robert J, Appleton, Sarah, Heinzer, Raphael

“…Background Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep…”
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Regular snoring is associated with uncontrolled hypertension by Lechat, Bastien, Naik, Ganesh, Appleton, Sarah, Manners, Jack, Scott, Hannah, Nguyen, Duc Phuc, Escourrou, Pierre, Adams, Robert, Catcheside, Peter, Eckert, Danny J.

“…Snoring may be a risk factor for cardiovascular disease independent of other co-morbidities. However, most prior studies have relied on subjective,…”
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