Search Results - "ECKERDT, Frank"

Targeting BET bromodomain proteins in solid tumors by Sahai, Vaibhav, Redig, Amanda J, Collier, Katharine A, Eckerdt, Frank D, Munshi, Hidayatullah G

“…There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins…”
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Combined PI3Kα-mTOR Targeting of Glioma Stem Cells by Eckerdt, Frank D., Bell, Jonathan B., Gonzalez, Christopher, Oh, Michael S., Perez, Ricardo E., Mazewski, Candice, Fischietti, Mariafausta, Goldman, Stewart, Nakano, Ichiro, Platanias, Leonidas C.

“…Glioblastoma (GBM) is the most common and lethal primary intrinsic tumour of the adult brain and evidence indicates disease progression is driven by glioma…”
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Polo-like kinase 1 inhibitors SBE13 and BI 2536 induce different responses in primary cells by Eckerdt, Frank

“…Comment on: Keppner S, et al. Cell Cycle 2011; 10:708-720…”
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MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma by Bell, Jonathan B, Eckerdt, Frank D, Alley, Kristen, Magnusson, Lisa P, Hussain, Hridi, Bi, Yingtao, Arslan, Ahmet Dirim, Clymer, Jessica, Alvarez, Angel A, Goldman, Stewart, Cheng, Shi-Yuan, Nakano, Ichiro, Horbinski, Craig, Davuluri, Ramana V, James, C David, Platanias, Leonidas C

“…Glioblastoma multiforme remains the deadliest malignant brain tumor, with glioma stem cells (GSC) contributing to treatment resistance and tumor recurrence. We…”
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Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer by Kumar, Krishan, Chow, Christina R, Ebine, Kazumi, Arslan, Ahmet D, Kwok, Benjamin, Bentrem, David J, Eckerdt, Frank D, Platanias, Leonidas C, Munshi, Hidayatullah G

“…Human pancreatic ductal adenocarcinoma (PDAC) tumors are associated with dysregulation of mRNA translation. In this report, it is demonstrated that PDAC cells…”
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Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma by Katagi, Hiroaki, Takata, Nozomu, Aoi, Yuki, Zhang, Yongzhan, Rendleman, Emily J, Blyth, Gavin T, Eckerdt, Frank D, Tomita, Yusuke, Sasaki, Takahiro, Saratsis, Amanda M, Kondo, Akihide, Goldman, Stewart, Becher, Oren J, Smith, Edwin, Zou, Lihua, Shilatifard, Ali, Hashizume, Rintaro

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is associated with transcriptional dysregulation driven by H3K27 mutation. The super elongation…”
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HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma by Bell, Jonathan B., Rink, Jonathan S., Eckerdt, Frank, Clymer, Jessica, Goldman, Stewart, Thaxton, C. Shad, Platanias, Leonidas C.

“…Medulloblastoma is the most common paediatric malignant brain cancer and there is a need for new targeted therapeutic approaches to more effectively treat…”
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Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms by Saleiro, Diana, Wen, Jeremy Q., Kosciuczuk, Ewa M., Eckerdt, Frank, Beauchamp, Elspeth M., Oku, Chidera V., Blyth, Gavin T., Fischietti, Mariafausta, Ilut, Liliana, Colamonici, Marco, Palivos, William, Atsaves, Paula A., Tan, Dean, Kocherginsky, Masha, Weinberg, Rona Singer, Fish, Eleanor N., Crispino, John D., Hoffman, Ronald, Platanias, Leonidas C.

“…Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. IFNα is highly…”
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Polo-like kinase 1: Target and regulator of anaphase-promoting complex/cyclosome-dependent proteolysis by ECKERDT, Frank, STREBHARDT, Klaus

“…Polo-like kinase 1 (Plk1) is a key regulator of progression through mitosis. Although Plk1 seems to be dispensable for entry into mitosis, its role in spindle…”
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Schlafen 5 as a novel therapeutic target in pancreatic ductal adenocarcinoma by Fischietti, Mariafausta, Eckerdt, Frank, Blyth, Gavin T., Arslan, Ahmet D., Mati, William M., Oku, Chidera V., Perez, Ricardo E., Lee-Chang, Catalina, Kosciuczuk, Ewa M., Saleiro, Diana, Beauchamp, Elspeth M., Lesniak, Maciej S., Verzella, Daniela, Sun, Leyu, Fish, Eleanor N., Yang, Guang-Yu, Qiang, Wenan, Platanias, Leonidas C.

“…We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC)…”
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Modeling Therapy-Driven Evolution of Glioblastoma with Patient-Derived Xenografts by McCord, Matthew, Bartom, Elizabeth, Burdett, Kirsten, Baran, Aneta, Eckerdt, Frank D, Balyasnikova, Irina V, McCortney, Kathleen, Sears, Thomas, Cheng, Shi-Yuan, Sarkaria, Jann N, Stupp, Roger, Heimberger, Amy B, Ahmed, Atique, James, Charles David, Horbinski, Craig

“…Adult-type diffusely infiltrating gliomas, of which glioblastoma is the most common and aggressive, almost always recur after treatment and are fatal. Improved…”
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Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells by JUPING YUAN, RUILAN YAN, KRÄMER, Andrea, ECKERDT, Frank, ROLLER, Marc, KAUFMANN, Manfred, STREBHARDT, Klaus

“…Cyclin B1 is the regulatory subunit of M-phase promoting factor, and proper regulation of cyclin B1 is essential for the initiation of mitosis. Increasing…”
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Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation by Bell, Jonathan B, Eckerdt, Frank, Dhruv, Harshil D, Finlay, Darren, Peng, Sen, Kim, Seungchan, Kroczynska, Barbara, Beauchamp, Elspeth M, Alley, Kristen, Clymer, Jessica, Goldman, Stewart, Cheng, Shi-Yuan, James, C David, Nakano, Ichiro, Horbinski, Craig, Mazar, Andrew P, Vuori, Kristiina, Kumthekar, Priya, Raizer, Jeffrey, Berens, Michael E, Platanias, Leonidas C

“…Mesenchymal (MES) and proneural (PN) are two distinct glioma stem cell (GSC) populations that drive therapeutic resistance in glioblastoma (GBM). We screened a…”
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Regulation of Greatwall kinase by protein stabilization and nuclear localization by Yamamoto, Tomomi M, Wang, Ling, Fisher, Laura A, Eckerdt, Frank D, Peng, Aimin

“…Greatwall (Gwl) functions as an essential mitotic kinase by antagonizing protein phosphatase 2A. In this study we identified Hsp90, Cdc37 and members of the…”
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LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression by Eckerdt, Frank, Perez-Neut, Mathew, Colamonici, Oscar R

“…Cell cycle transitions are governed by the timely expression of cyclins, the activating subunits of Cyclin-dependent kinases (Cdks), which are responsible for…”
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A simple, low-cost staining method for rapid-throughput analysis of tumor spheroids by Eckerdt, Frank, Alvarez, Angel, Bell, Jonathan, Arvanitis, Constadina, Iqbal, Asneha, Arslan, Ahmet D, Hu, Bo, Cheng, Shi-Yuan, Goldman, Stewart, Platanias, Leonidas C

“…Tumor spheroids are becoming an important tool for the investigation of cancer stem cell (CSC) function in tumors; thus, low-cost and high-throughput methods…”
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Spindle Pole Regulation by a Discrete Eg5-Interacting Domain in TPX2 by Eckerdt, Frank, Eyers, Patrick A., Lewellyn, Andrea L., Prigent, Claude, Maller, James L.

“…Targeting protein for Xklp2 (TPX2) activates the Ser/Thr kinase Aurora A in mitosis and targets it to the mitotic spindle [1, 2]. These effects on Aurora A are…”
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Identification of a Polo-like Kinase 4-Dependent Pathway for De Novo Centriole Formation by Eckerdt, Frank, Yamamoto, Tomomi M., Lewellyn, Andrea L., Maller, James L.

“…Supernumerary centrosomes are a key cause of genomic instability in cancer cells [ 1]. New centrioles can be generated by duplication with a mother centriole…”
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Discovery of a distinct domain in cyclin A sufficient for centrosomal localization independently of Cdk binding by Pascreau, Gaetan, Eckerdt, Frank, Churchill, Mair E.A, Maller, James L

“…Centrosomes have recently emerged as key regulators of the cell cycle. The G1/S transition requires a functional centrosome, and centrosomal localization of…”
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Polo-like Kinase 1-mediated Phosphorylation Stabilizes Pin1 by Inhibiting Its Ubiquitination in Human Cells by Eckerdt, Frank, Yuan, Juping, Saxena, Krishna, Martin, Bernd, Kappel, Sven, Lindenau, Christine, Kramer, Andrea, Naumann, Steffen, Daum, Sebastian, Fischer, Gunter, Dikic, Ivan, Kaufmann, Manfred, Strebhardt, Klaus

“…The Polo-like kinase 1 (Plk1) is a key regulator of mitosis. It is reported that the human peptidyl-prolyl cis/trans-isomerase Pin1 binds to Plk1 from mitotic…”
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