Search Results - "ECKENHOFF, Roderic G"

Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review by Yuki, Koichi, Eckenhoff, Roderic G.

“…Volatile anesthetics (VAs) have been in clinical use for a very long time. Their mechanism of action is yet to be fully delineated, but multiple ion channels…”
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Human Alzheimer and Inflammation Biomarkers after Anesthesia and Surgery by TANG, Junxia X, BARANOV, Dimitry, HAMMOND, Mary, SHAW, Leslie M, ECKENHOFF, Maryellen F, ECKENHOFF, Roderic G

“…The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on…”
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Volatile anesthetics affect macrophage phagocytosis by Zha, Hui, Matsunami, Erika, Blazon-Brown, Nathan, Koutsogiannaki, Sophia, Hou, Lifei, Bu, Weiming, Babazada, Hasan, Odegard, Kirsten C, Liu, Renyu, Eckenhoff, Roderic G, Yuki, Koichi

“…Perioperative infections, particularly surgical site infections pose significant morbidity and mortality. Phagocytosis is a critical step for microbial…”
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Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team by Peden, Carol J, Miller, Thomas R, Deiner, Stacie G, Eckenhoff, Roderic G, Fleisher, Lee A

“…Delirium and postoperative neurocognitive disorder are the commonest perioperative complications in patients more than 65 yr of age. However, data suggest that…”
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Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll‐like receptor 4 system by Okuno, Toshiaki, Koutsogiannaki, Sophia, Hou, Lifei, Bu, Weiming, Ohto, Umeharu, Eckenhoff, Roderic G., Yokomizo, Takehiko, Yuki, Koichi

“…General anesthesia has been the requisite component of surgical procedures for over 150 yr. Although immunomodulatory effects of volatile anesthetics have been…”
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Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics by Covarrubias, Manuel, Barber, Annika F., Carnevale, Vincenzo, Treptow, Werner, Eckenhoff, Roderic G.

“…General anesthesia is a relatively safe medical procedure, which for nearly 170 years has allowed life saving surgical interventions in animals and people…”
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Differential general anesthetic effects on microglial cytokine expression by Ye, Xuefei, Lian, Qingquan, Eckenhoff, Maryellen F, Eckenhoff, Roderic G, Pan, Jonathan Z

“…Post-operative cognitive dysfunction has been widely observed, especially in older patients. An association of post-operative cognitive dysfunction with the…”
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The role of propofol hydroxyl group in 5-lipoxygenase recognition by Yuki, Koichi, Bu, Weiming, Eckenhoff, Roderic G., Yokomizo, Takehiko, Okuno, Toshiaki

“…Propofol is a clinically important intravenous anesthetic. We previously reported that it directly inhibited 5-lipoxygenase (5-LOX), a key enzyme for…”
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Computational Investigation of Cholesterol Binding Sites on Mitochondrial VDAC by Weiser, Brian P, Salari, Reza, Eckenhoff, Roderic G, Brannigan, Grace

“…The mitochondrial voltage-dependent anion channel (VDAC) allows passage of ions and metabolites across the mitochondrial outer membrane. Cholesterol binds…”
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Antagonism of propofol anesthesia by alkyl-fluorobenzene derivatives by Plasencia, Diana M., Rodgers, Liam H., Knighton, Alexys R., Eckenhoff, Roderic G., White, E. Railey

“…Despite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated…”
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The Common Inhalational Anesthetic Isoflurane Induces Apoptosis via Activation of Inositol 1,4,5-Trisphosphate Receptors by HUAFENG WEI, GE LIANG, HUI YANG, QIUJUN WANG, HAWKINS, Brian, MADESH, Muniswamy, SHOUPING WANG, ECKENHOFF, Roderic G

“…Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on…”
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Modulation of a voltage-gated Na+channel by sevoflurane involves multiple sites and distinct mechanisms by Barber, Annika F., Carnevale, Vincenzo, Klein, Michael L., Eckenhoff, Roderic G., Covarrubias, Manuel

“…Halogenated inhaled general anesthetic agents modulate voltage-gated ion channels, but the underlying molecular mechanisms are not understood. Many general…”
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Propofol inhibits prokaryotic voltage-gated Na + channels by promoting activation-coupled inactivation by Yang, Elaine, Granata, Daniele, Eckenhoff, Roderic G, Carnevale, Vincenzo, Covarrubias, Manuel

“…Propofol is widely used in the clinic for the induction and maintenance of general anesthesia. As with most general anesthetics, however, our understanding of…”
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Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain by Brannigan, Grace, LeBard, David N., Hénin, Jérôme, Eckenhoff, Roderic G., Klein, Michael L.

“…An extensive search for isoflurane binding sites in the nicotinic acetylcholine receptor (nAChR) and the proton gated ion channel from Gloebacter violaceus…”
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Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors by Woll, Kellie A., Zhou, Xiaojuan, Bhanu, Natarajan V., Garcia, Benjamin A., Covarrubias, Manuel, Miller, Keith W., Eckenhoff, Roderic G.

“…Most general anesthetics enhance GABA type A (GABAA) receptor activity at clinically relevant concentrations. Sites of action of volatile anesthetics on the…”
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Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics by Bianchi, Shannon L, Tran, Thuy, Liu, ChuiLiang, Lin, Susan, Li, Yujuan, Keller, Jason M, Eckenhoff, Roderic G, Eckenhoff, Maryellen F

“…Abstract Inhaled anesthetics have been shown to increase the aggregation of amyloid beta in vitro through the stabilization of intermediate toxic oligomers,…”
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A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia by Friedman, Eliot B, Sun, Yi, Moore, Jason T, Hung, Hsiao-Tung, Meng, Qing Cheng, Perera, Priyan, Joiner, William J, Thomas, Steven A, Eckenhoff, Roderic G, Sehgal, Amita, Kelz, Max B

“…One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable…”
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The effect of anesthetics on toll like receptor 9 by Koutsogiannaki, Sophia, Bu, Weiming, Hou, Lifei, Shibamura‐Fujiogi, Miho, Ishida, Hanako, Ohto, Umeharu, Eckenhoff, Roderic G., Yuki, Koichi

“…Toll like receptors (TLRs) are critical receptors to respond to danger signals, and their functions are relevant in the perioperative period. We previously…”
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Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats by Mansouri, Mohammed Taghi, Fidler, Jonathan A., Meng, Qing Cheng, Eckenhoff, Roderic G., García, Paul S.

“…Clinical studies have demonstrated sex-related differences in recovery from surgical anesthesia. This study aimed to characterize the emergence pattern…”
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Propofol Inhibits SIRT2 Deacetylase through a Conformation-specific, Allosteric Site by Weiser, Brian P., Eckenhoff, Roderic G.

“…meta-Azi-propofol (AziPm) is a photoactive analog of the general anesthetic propofol. We photolabeled a myelin-enriched fraction from rat brain with [3H]AziPm…”
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