Search Results - "ECKELS, K. H"

A human challenge model for dengue infection reveals a possible protective role for sustained interferon gamma levels during the acute phase of illness by Gunther, V.J, Putnak, R, Eckels, K.H, Mammen, M.P, Scherer, J.M, Lyons, A, Sztein, M.B, Sun, W

“…Abstract Dengue has recently been defined by the World Health Organization as a major international public health concern. Although several vaccine candidates…”
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Evaluation of Dengue Virus strains for human challenge studies by Mammen, M.P, Lyons, A, Innis, B.L, Sun, W, McKinney, D, Chung, R.C.Y, Eckels, K.H, Putnak, R, Kanesa-thasan, N, Scherer, J.M, Statler, J, Asher, L.V, Thomas, S.J, Vaughn, D.W

“…Highlights • Challenge of flavivirus-naïve adults with dengue viruses in a controlled setting resulted in dengue fever (DF). • Fifteen flavivirus-naïve adult…”
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Phase 1 studies of Walter Reed Army Institute of Research candidate attenuated dengue vaccines: selection of safe and immunogenic monovalent vaccines by Kanesa-Thasan, N, Edelman, R, Tacket, C O, Wasserman, S S, Vaughn, D W, Coster, T S, Kim-Ahn, G J, Dubois, D R, Putnak, J R, King, A, Summers, P L, Innis, B L, Eckels, K H, Hoke, Jr, C H

“…We describe the results of initial safety testing of 10 live-attenuated dengue virus (DENV) vaccine candidates modified by serial passage in primary dog kidney…”
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Development of a Purified, Inactivated, Dengue-2 Virus Vaccine Prototype in Vero Cells: Immunogenicity and Protection in Mice and Rhesus Monkeys by Putnak, Robert, Barvir, David A., Burrous, Jeanne M., Dubois, Doria R., D'Andrea, Valerie M., Hoke, Charles H., Sadoff, Jerald C., Eckels, Kenneth H.

“…The feasibility of a purified, inactivated dengue (DEN) vaccine made in Vero cells was explored. A DEN-2 virus candidate was chosen for production of a…”
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Evaluation of recombinant dengue viral envelope B domain protein antigens for the detection of dengue complex-specific antibodies by Simmons, M, Porter, K R, Escamilla, J, Graham, R, Watts, D M, Eckels, K H, Hayes, C G

“…To increase the specificity of dengue (DEN) diagnosis based on antibody detection, we have evaluated recombinant proteins as antigens that incorporate most of…”
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Small-animal model to measure efficacy and immunogenicity of Shigella vaccine strains by HARTMAN, A. B, POWELL, C. J, SCHULTZ, C. L, OAKS, E. V, ECKELS, K. H

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Mice immunized with recombinant vaccinia virus expressing dengue 4 virus structural proteins with or without nonstructural protein NS1 are protected against fatal dengue virus encephalitis by BRAY, M, BANGTI ZHAO, MARKOFF, L, ECKELS, K. H, CHANOCK, R. M, CHING-JUH LAI

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Flavivirus entry into cultured mosquito cells and human peripheral blood monocytes by Hase, T, Summers, P.L, Eckels, K.H

“…The entry modes of Japanese encephalitis (JE) and dengue-2 (DEN-2) viruses into C6/36 mosquito cells and of DEN-2 virus into human peripheral blood monocytes…”
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A Live Attenuated Dengue-1 Vaccine Candidate (45AZ5) Passaged in Primary Dog Kidney Cell Culture Is Attenuated and Immunogenic for Humans by Edelman, Robert, Tacket, Carol O., Wasserman, Steven S., Vaughn, David W., Eckels, Kenneth H., Dubois, Doria R., Summers, Peter L., Hoke, Charles H.

“…A dengue-1 candidate vaccine (45AZ5), previously found to be underattenuated in 2 volunteers, was further attenuated by passage in primary dog kidney (PDK)…”
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Immunization of mice with dengue structural proteins and nonstructural protein NS1 expressed by baculovirus recombinant induces resistance to dengue virus encephalitis by YI-MING ZHANG, HAYES, E. P, MCCARTY, T. C, DUBOIS, D. R, SUMMERS, P. L, ECKELS, K. H, CHANOCK, R. M, CHING-JUH LAI

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Immunization of monkeys with baculovirus-dengue type-4 recombinants containing envelope and nonstructural proteins: evidence of priming and partial protection by Eckels, K H, Dubois, D R, Summers, P L, Schlesinger, J J, Shelly, M, Cohen, S, Zhang, Y M, Lai, C J, Kurane, I, Rothman, A

“…Groups of rhesus monkeys were immunized with baculovirus-dengue type-4 (DEN-4) recombinant-infected cell extracts. One recombinant contained all of the DEN-4…”
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Monoclonal antibodies against dengue 2 virus E-glycoprotein protect mice against lethal dengue infection by Kaufman, B M, Summers, P L, Dubois, D R, Eckels, K H

“…A panel of 11 murine monoclonal antibodies directed against dengue type 2 was evaluated for antigen specificity by dot immunobinding assay and Western blot…”
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Dengue virus-specific human CD4+ T-lymphocyte responses in a recipient of an experimental live-attenuated dengue virus type 1 vaccine: bulk culture proliferation, clonal analysis, and precursor frequency determination by Green, S, Kurane, I, Edelman, R, Tacket, C O, Eckels, K H, Vaughn, D W, Hoke, Jr, C H, Ennis, F A

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Delayed-Type Hypersensitivity Skin Testing using Third Variable Loop Peptides Identifies T Lymphocyte Epitopes in Human Immunodeficiency Virus-Infected Persons by Sitz, Karl V., Price, Lawrence D. Loomis, Kim, Silvia Ratto, Kenner, Julie R., Sau, Purnima, Eckels, Kenneth H., Redfield, Robert R., Birx, Deborah L.

“…Cellular immune responses to human immunodeficiency virus type 1 (HIV-1) infection, particularly in vivo responses, have been difficult to study in large…”
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Quantitative Relationship Between Oral Temperature and Severity of Illness Following Inoculation with Candidate Attenuated Dengue Virus Vaccines by Mackowiak, Philip A., Wasserman, Steven S., Tacket, Carol O., Vaughn, David W., Eckels, Kenneth H., Dubois, Doria R., Hoke, Charles H., Edelman, Robert

“…The relationship between oral temperature and other parameters of illness was examined in 51 adult volunteers who were inoculated experimentally with partially…”
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Hepatitis A in the US Army: epidemiology and vaccine development by Hoke, Jr, C H, Binn, L N, Egan, J E, DeFraites, R F, MacArthy, P O, Innis, B L, Eckels, K H, Dubois, D, D'Hondt, E, Sjogren, M H

“…Control of hepatitis A has been an important concern for US military forces in war and peace. Immune serum globulin, although effective, is exceedingly…”
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Lack of attenuation of a candidate dengue 1 vaccine (45AZ5) in human volunteers by McKee, Jr, K T, Bancroft, W H, Eckels, K H, Redfield, R R, Summers, P L, Russell, P K

“…A dengue type 1, candidate live virus vaccine (45AZ5) was prepared by serial virus passage in fetal rhesus lung cells. Infected cells were treated with a…”
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Maturation process of Japanese encephalitis virus in cultured mosquito cells in vitro and mouse brain cells in vivo by HASE, T, SUMMERS, P. L, ECKELS, K. H, BAZE, W. B

“…The maturation process of Japanese encephalitis (JE) virus in C6/36 cells in vitro and in mouse brain cells in vivo was studied by electron microscopy. In the…”
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electron and immunoelectron microscopic study of Dengue-2 virus infection of cultured mosquito cells: maturation events by Hase, T, Summers, P.L, Eckels, K.H, Baze, W.B

“…The maturation process of dengue-2 virus in C6/36 mosquito cells was studied by electron microscopy at 12, 16, 24, 48, and 78 hours postinoculation (p.i.) and…”
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Infection of Aedes albopictus and Aedes aegypti mosquitoes with dengue parent and progeny candidate vaccine viruses: a possible marker of human attenuation by Schoepp, R J, Beaty, B J, Eckels, K H

“…Dengue (DEN-1) and DEN-4 parent (P) and progeny candidate vaccine (CV) viruses were compared in their abilities to infect and to replicate in Aedes aegypti and…”
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