Search Results - "ECK, Michael J"

Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes by Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B., Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A., Jeon, Hyesung, Eck, Michael J.

“…RAF family kinases are RAS-activated switches that initiate signalling through the MAP kinase cascade to control cellular proliferation, differentiation and…”
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EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors by Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A

“…Mutant selective irreversible pyrimidine-based EGFR kinase inhibitors, including WZ4002, CO-1686, and AZD9291, are effective in preclinical models and in lung…”
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Mechanism and function of formins in the control of actin assembly by Goode, Bruce L, Eck, Michael J

“…Formins are a widely expressed family of proteins that govern cell shape, adhesion, cytokinesis, and morphogenesis by remodeling the actin and microtubule…”
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Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING by Yin, Qian, Tian, Yuan, Kabaleeswaran, Venkataraman, Jiang, Xiaomo, Tu, Daqi, Eck, Michael J., Chen, Zhijian J., Wu, Hao

“…Detection of foreign materials is the first step of successful immune responses. Stimulator of interferon genes (STING) was shown to directly bind cyclic…”
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The FERM domain: organizing the structure and function of FAK by Frame, Margaret C, Eck, Michael J, Patel, Hitesh, Serrels, Bryan, Lietha, Daniel

“…Key Points Focal adhesion kinase (FAK) is a scaffold and kinase protein that binds to itself and cellular partners through its four-point-one, ezrin, radixin,…”
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Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer by Eck, Michael J., Yun, Cai-Hong

“…EGFR and other ErbB-family tyrosine kinases are overexpressed in many human tumors, and their aberrant expression and mutational activation is associated with…”
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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression by Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M., O’Neill, Brian T., Ramirez, Alfred K., Pan, Hui, Winnay, Jonathon N., Boucher, Jeremie, Eck, Michael J., Kahn, C. Ronald

“…Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate…”
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T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP by Yun, Cai-Hong, Mengwasser, Kristen E, Toms, Angela V, Woo, Michele S, Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J

“…Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase…”
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Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors by Kosaka, Takayuki, Tanizaki, Junko, Paranal, Raymond M, Endoh, Hideki, Lydon, Christine, Capelletti, Marzia, Repellin, Claire E, Choi, Jihyun, Ogino, Atsuko, Calles, Antonio, Ercan, Dalia, Redig, Amanda J, Bahcall, Magda, Oxnard, Geoffrey R, Eck, Michael J, Jänne, Pasi A

“…Insertion mutations in EGFR and HER2 both occur at analogous positions in exon 20. Non-small cell lung cancer (NSCLC) patients with tumors harboring these…”
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Cryo-EM structure of a RAS/RAF recruitment complex by Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J.

“…RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound RAS, whereupon they initiate signaling through the MAP kinase cascade…”
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Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer by Yasuda, Hiroyuki, Park, Eunyoung, Yun, Cai-Hong, Sng, Natasha J, Lucena-Araujo, Antonio R, Yeo, Wee-Lee, Huberman, Mark S, Cohen, David W, Nakayama, Sohei, Ishioka, Kota, Yamaguchi, Norihiro, Hanna, Megan, Oxnard, Geoffrey R, Lathan, Christopher S, Moran, Teresa, Sequist, Lecia V, Chaft, Jamie E, Riely, Gregory J, Arcila, Maria E, Soo, Ross A, Meyerson, Matthew, Eck, Michael J, Kobayashi, Susumu S, Costa, Daniel B

“…Epidermal growth factor receptor (EGFR) gene mutations (G719X, exon 19 deletions/insertions, L858R, and L861Q) predict favorable responses to EGFR tyrosine…”
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Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex by Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J.

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Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors by Beyett, Tyler S., To, Ciric, Heppner, David E., Rana, Jaimin K., Schmoker, Anna M., Jang, Jaebong, De Clercq, Dries J. H., Gomez, Gabriel, Scott, David A., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J.

“…Lung cancer is frequently caused by activating mutations in the epidermal growth factor receptor (EGFR). Allosteric EGFR inhibitors offer promise as the next…”
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Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6 by Park, Eunyoung, Kim, Nayoung, Ficarro, Scott B, Zhang, Yi, Lee, Byung Il, Cho, Ahye, Kim, Kihong, Park, Angela K J, Park, Woong-Yang, Murray, Bradley, Meyerson, Matthew, Beroukhim, Rameen, Marto, Jarrod A, Cho, Jeonghee, Eck, Michael J

“…Mig6 phosphorylation at two consecutive tyrosines induces rearrangements that lead to Mig6 sticking to and inhibiting the same EGFR that catalyzed its…”
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Mechanism for activation of mutated epidermal growth factor receptors in lung cancer by Red Brewer, Monica, Yun, Cai-Hong, Lai, Darson, Lemmon, Mark A, Eck, Michael J, Pao, William

“…The initiation of epidermal growth factor receptor (EGFR) kinase activity proceeds via an asymmetric dimerization mechanism in which a “donor” tyrosine kinase…”
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Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes by Goñi, Guillermina M, Epifano, Carolina, Boskovic, Jasminka, Camacho-Artacho, Marta, Zhou, Jing, Bronowska, Agnieszka, Martín, M Teresa, Eck, Michael J, Kremer, Leonor, Gräter, Frauke, Gervasio, Francesco Luigi, Perez-Moreno, Mirna, Lietha, Daniel

“…Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase (NRTK) with key roles in integrating growth and cell matrix adhesion signals, and FAK is a major…”
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The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers by Sasaki, Takaaki, Okuda, Katsuhiro, Zheng, Wei, Butrynski, James, Capelletti, Marzia, Wang, Liping, Gray, Nathanael S, Wilner, Keith, Christensen, James G, Demetri, George, Shapiro, Geoffrey I, Rodig, Scott J, Eck, Michael J, Jänne, Pasi A

“…The ALK kinase inhibitor crizotinib (PF-02341066) is clinically effective in patients with ALK-translocated cancers, but its efficacy will ultimately be…”
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The structural basis of PTEN regulation by multi-site phosphorylation by Dempsey, Daniel R., Viennet, Thibault, Iwase, Reina, Park, Eunyoung, Henriquez, Stephanie, Chen, Zan, Jeliazkov, Jeliazko R., Palanski, Brad A., Phan, Kim L., Coote, Paul, Gray, Jeffrey J., Eck, Michael J., Gabelli, Sandra B., Arthanari, Haribabu, Cole, Philip A.

“…Phosphatase and tensin homolog (PTEN) is a phosphatidylinositol-3,4,5-triphosphate (PIP 3 ) phospholipid phosphatase that is commonly mutated or silenced in…”
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Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1 by Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.

“…Upon stimulation by pathogen-associated inflammatory signals, TANK-binding kinase 1 (TBK1) induces type I interferon expression and modulates nuclear factor κB…”
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Structural Basis for the Autoinhibition of Focal Adhesion Kinase by Lietha, Daniel, Cai, Xinming, Ceccarelli, Derek F.J., Li, Yiqun, Schaller, Michael D., Eck, Michael J.

“…Appropriate tyrosine kinase signaling depends on coordinated sequential coupling of protein-protein interactions with catalytic activation. Focal adhesion…”
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