Search Results - "EBY, Michael T"

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models by HOEFLICH, Klaus P, GRAY, Daniel C, MURRAY, Lesley J, DAVIS, David P, SESHAGIRI, Somasekar, EBY, Michael T, TIEN, Janet Y, LEO WONG, BOWER, Janeko, GOGINENI, Alvin, JIPING ZHA, COLE, Mary J, STERN, Howard M

“…The usual paradigm for developing kinase inhibitors in oncology is to use a high-affinity proof-of-concept inhibitor with acceptable metabolic properties for…”
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Differential Inactivation of Caspase-8 in Lung Cancers by Shivapurkar, Narayan, Toyooka, Shinichi, Eby, Michael T., Huang, Chun Xian, Sathyanarayana, Ubaradka G., Cunningham, H. Thomas, Reddy, Jyotsna L., Brambilla, Elizabeth, Takahashi, Takashi, Minna, John D., Chaudhary, Preet, Gazdar, A.

“…Caspase-8 (CASP8) is an apoptosis inducing cysteine protease which is activated through the formation of a death-inducing signaling complex when death…”
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Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins by CHAUDHARY, P. M, JASMIN, A, EBY, M. T, HOOD, L

“…Death Effector Domains (DEDs) have been known to mediate the recruitment of Caspase 8 and its homologs to the aggregated death-inducing signaling complex…”
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Activation of the NF-κB pathway by Caspase 8 and its homologs by CHAUDHARY, Preet M, EBY, Michael T, JASMIN, Alan, KUMAR, Arvind, LI LIU, HOOD, Leroy

“…Caspase 8 is the most proximal caspase in the caspase cascade and has been known for its role in the mediation of cell death by various death receptors…”
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Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila by KAUPPILA, Saila, MAATY, Walid S. A, ABRAMS, John M, CHAUDHARY, Preet M, PO CHEN, TOMAR, Raghuvir S, EBY, Michael T, CHAPO, Joe, CHEW, Sukit, RATHORE, Nisha, ZACHARIAH, Sunny, SINHA, Suwan K

“…In mammals, members of the tumor necrosis factor (TNF) family play an important role in the regulation of cellular proliferation, differentiation and…”
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TAJ, a Novel Member of the Tumor Necrosis Factor Receptor Family, Activates the c-Jun N-terminal Kinase Pathway and Mediates Caspase-independent Cell Death by Eby, Michael T., Jasmin, Alan, Kumar, Arvind, Sharma, Kiran, Chaudhary, Preet M.

“…We have isolated a novel member of the TNFR family, designated TAJ, that is highly expressed during embryonic development. TAJ possesses a unique cytoplasmic…”
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Regulation of ERK3/MAPK6 expression by BRAF by HOEFLICH, Klaus P, EBY, Michael T, FORREST, William F, GRAY, Daniel C, TIEN, Janet Y, STERN, Howard M, MURRAY, Lesley J, DAVIS, David P, MODRUSAN, Zora, SESHAGIRI, Somasekar

“…Several forms of cancer are characterized by frequent activating mutations in the serine/threonine kinase, BRAF. Substitution of glutamic acid for valine at…”
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Activation of the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Overexpression of Caspase-8 and Its Homologs by Chaudhary, P M, Eby, M T, Jasmin, A, Hood, L

“…Caspase-8 is the most proximal caspase in the caspase cascade and possesses a prodomain consisting of two homologous death effector domains (DEDs). We have…”
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Role of MRIT/cFLIP in Protection Against Chemotherapy-Induced Apoptosis by Matta, Hittu, Eby, Michael T., Gazdar, Adi F., Chaudhary, Preet M.

“…MRIT (Mach-related inducer of toxicity)/cFLIP (cellular FADD like interlukin1-β converting enzyme inhibitory protein) is a proteolytically inactive structural…”
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The Human Herpes Virus 8-encoded Viral FLICE Inhibitory Protein Physically Associates with and Persistently Activates the IκB Kinase Complex by Liu, Li, Eby, Michael T., Rathore, Nisha, Sinha, Suwan K., Kumar, Arvind, Chaudhary, Preet M.

“…The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in…”
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The Ectodermal Dysplasia Receptor Activates the Nuclear Factor-κB, JNK, and Cell Death Pathways and Binds to Ectodysplasin A by Kumar, Arvind, Eby, Michael T., Sinha, Suwan, Jasmin, Alan, Chaudhary, Preet M.

“…The ectodermal dysplasia receptor (EDAR) is a recently isolated member of the tumor necrosis factor receptor family that has been shown to play a key role in…”
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The Human Herpes Virus 8-encoded Viral FLICE Inhibitory Protein Physically Associates with and Persistently Activates the IκB Kinase Complex by Li Liu, Michael T. Eby, Nisha Rathore, Suwan K. Sinha, Arvind Kumar, Preet M. Chaudhary

“…The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in…”
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The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex by Liu, Li, Eby, Michael T, Rathore, Nisha, Sinha, Suwan K, Kumar, Arvind, Chaudhary, Preet M

“…The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in…”
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Cytotoxicity of Tumor Necrosis Factor related apoptosis-inducing ligand towards Ewing's sarcoma cell lines by KUMAR, Arvind, JASMIN, Alan, EBY, Michael T, CHAUDHARY, Preet M

“…Death ligands of the Tumor Necrosis Factor (TNF) family are known to induce apoptosis upon binding to their cognate receptors. However, the clinical utility of…”
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Role of MRIT/cFLIP in Protection Against Chemotherapy-Induced Apoptosis by Adi F. Gazdar, Preet M. Chaudhary, Michael T. Eby, Hittu Matta

“…MRIT (Mach-related inducer of toxicity)/cFLIP (cellular FADD like interlukin1-β converting enzyme inhibitory protein) is a proteolytically inactive structural…”
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The Ectodermal Dysplasia Receptor Activates the Nuclear Factor-κB, JNK, and Cell Death Pathways and Binds to Ectodysplasin A by Arvind Kumar, Michael T. Eby, Suwan Sinha, Alan Jasmin, Preet M. Chaudhary

“…The ectodermal dysplasia receptor (EDAR) is a recently isolated member of the tumor necrosis factor receptor family that has been shown to play a key role in…”
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Activation of the NF-[kappa]B pathway by Caspase 8 and its homologs by Chaudhary, Preet M, Eby, Michael T, Jasmin, Alan, Kumar, Arvind, Liu, Li, Hood, Leroy

“…Caspase 8 is the most proximal caspase in the caspase cascade and has been known for its role in the mediation of cell death by various death receptors…”
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