Search Results - "EBERS, G. C"

Review: The role of vitamin D in nervous system health and disease by DeLuca, G. C., Kimball, S. M., Kolasinski, J., Ramagopalan, S. V., Ebers, G. C.

“…Vitamin D and its metabolites have pleomorphic roles in both nervous system health and disease. Animal models have been paramount in contributing to our…”
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Age and disability accumulation in multiple sclerosis by SCALFARI, A, NEUHAUS, A, DAUMER, M, EBERS, G. C, MURARO, P. A

“…We tested the hypothesis that age is a prognostic factor with respect to long-term accumulation of disability in multiple sclerosis (MS). Kaplan-Meier analysis…”
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Survival in MS: A randomized cohort study 21 years after the start of the pivotal IFNβ-1b trial by GOODIN, D. S, REDER, A. T, KNAPPERTZ, V, EBERS, G. C, CUTTER, G, KREMENCHUTZKY, M, OGER, J, LANGDON, D, RAMETTA, M, BECKMANN, K, DESIMONE, T. M

“…To examine the effects of interferon beta (IFNβ)-1b on all-cause mortality over 21 years in the cohort of 372 patients who participated in the pivotal…”
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The natural history of multiple sclerosis: a geographically based study 9: Observations on the progressive phase of the disease by Kremenchutzky, M., Rice, G. P. A., Baskerville, J., Wingerchuk, D. M., Ebers, G. C.

“…The clinical features of relapses and progression largely define multiple sclerosis phenotypes. A relapsing course is followed by chronic progression in some…”
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MRI as an outcome in multiple sclerosis clinical trials by DAUMER, M, NEUHAUS, A, MORRISSEY, S, HINTZEN, R, EBERS, G. C

“…T2-weighted and gadolinium enhanced T1-weighted MRI scans measure plaque burden and breakdown of the blood-brain barrier, respectively, in multiple sclerosis…”
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Disability as an outcome in MS clinical trials by EBERS, G. C, HEIGENHAUSER, L, DAUMER, M, LEDERER, C, NOSEWORTHY, J. H

“…Inferences about long-term effects of therapies in multiple sclerosis (MS) have been based on surrogate markers studied in short-term trials. Preventing…”
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Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial by Ebers, G C, Traboulsee, A, Li, D, Langdon, D, Reder, A T, Goodin, D S, Bogumil, T, Beckmann, K, Wolf, C, Konieczny, A

“…BackgroundEvidence for efficacy of disease-modifying drugs in multiple sclerosis (MS) comes from trials of short duration. We report results from a 16 y,…”
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The relationship of age with the clinical phenotype in multiple sclerosis by Scalfari, A, Lederer, C, Daumer, M, Nicholas, R, Ebers, GC, Muraro, PA

“…Background: The multiple sclerosis (MS) clinical course and relapses frequency before progression vary widely. Objective: To investigate the influence of age…”
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The contribution of demyelination to axonal loss in multiple sclerosis by DeLuca, G. C., Williams, K., Evangelou, N., Ebers, G. C., Esiri, M. M.

“…The traditional notion that multiple sclerosis is a primary demyelinating disease has led to a plaque-centred view of both aetiology and the pathogenesis of…”
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Regulation of major histocompatibility complex class II gene expression, genetic variation and disease by Handunnetthi, L, Ramagopalan, S V, Ebers, G C, Knight, J C

“…Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s,…”
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Relationship of UV exposure to prevalence of multiple sclerosis in England by RAMAGOPALAN, S. V, HANDEL, A. E, GIOVANNONI, G, RUTHERFORD SIEGEL, S, EBERS, G. C, CHAPLIN, G

“…To assess the potential relationship of ultraviolet B radiation (UVB) and Epstein-Barr virus (EBV) exposure in explaining the period prevalence of multiple…”
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Association of UV radiation with multiple sclerosis prevalence and sex ratio in France by ORTON, S.-M, WALD, L, CONFAVREUX, C, VUKUSIC, S, KROHN, J. P, RAMAGOPALAN, S. V, HERRERA, B. M, SADOVNICK, A. D, EBERS, G. C

“…French farmers and their families constitute an informative population to study multiple sclerosis (MS) prevalence and related epidemiology. We carried out an…”
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Twin Concordance and Sibling Recurrence Rates in Multiple Sclerosis by Willer, C. J., Dyment, D. A., Risch, N. J., Sadovnick, A. D., Ebers, G. C., The Canadian Collaborative Study Group

“…Size and ascertainment constraints often limit twin studies to concordance comparisons between identical and fraternal twins. Here we report the final results…”
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Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts by DeLuca, G. C., Ebers, G. C., Esiri, M. M.

“…Clinical, imaging, and pathological studies in multiple sclerosis have generally emphasized the relative preservation of axons in comparison with myelin…”
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A pilot study of oral calcitriol (1,25-dihydroxyvitamin D3) for relapsing–remitting multiple sclerosis by Wingerchuk, D M, Lesaux, J, Rice, G P A, Kremenchutzky, M, Ebers, G C

“…Background: Epidemiological and ecological studies suggest links between vitamin D deficiency and increased multiple sclerosis (MS) prevalence. Objective: To…”
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The extent of axonal loss in the long tracts in hereditary spastic paraplegia by DeLuca, G. C., Ebers, G. C., Esiri, M. M.

“…Hereditary spastic paraplegia (HSP) comprises a group of inherited neurodegenerative disorders with the shared characteristics of progressive weakness and…”
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Genetic and environmental factors and the distribution of multiple sclerosis in Europe by Handel, A. E., Handunnetthi, L., Giovannoni, G., Ebers, G. C., Ramagopalan, S. V.

“…Background:  The observation that the incidence of multiple sclerosis (MS) increases further from the equator has prompted considerable interest in the factors…”
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MHC transmission: Insights into gender bias in MS susceptibility by CHAO, M. J, RAMAGOPALAN, S. V, HERRERA, B. M, ORTON, S. M, HANDUNNETTHI, L, LINCOLN, M. R, DYMENT, D. A, SADOVNICK, A. D, EBERS, G. C

“…Major histocompatibility complex (MHC) genes dominate genetic susceptibility factors in multiple sclerosis (MS). Given the general consensus that incidence and…”
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extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus by DeLuca, G.C, Ramagopalan, S.V, Herrera, B.M, Dyment, D.A, Lincoln, M.R, Montpetit, A, Pugliatti, M, Barnardo, M.C.N, Risch, N.J, Sadovnick, A.D, Chao, M, Sotgiu, S, Hudson, T.J, Ebers, G.C

“…Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for variability in disease outcome. A cohort of sporadic MS…”
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Parent-of-origin effects in MS : Observations from avuncular pairs by HERRERA, B. M, RAMAGOPALAN, S. V, LINCOLN, M. R, ORTON, S. M, CHAO, M. J, SADOVNICK, A. D, EBERS, G. C

“…Multiple sclerosis (MS) is a complex neurologic disease of unknown etiology and inheritance pattern, but with increasing incidence among females. The study of…”
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