Search Results - "EBERLING, J. L"

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease by CHRISTINE, C. W, STARR, P. A, LARSON, P. S, EBERLING, J. L, JAGUST, W. J, HAWKINS, R. A, VANBROCKLIN, H. F, WRIGHT, J. F, BANKIEWICZ, K. S, AMINOFF, M. J

“…In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes…”
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Results from a phase I safety trial of hAADC gene therapy for Parkinson disease by EBERLING, J. L, JAGUST, W. J, CHRISTINE, C. W, STARR, P, LARSON, P, BANKIEWICZ, K. S, AMINOFF, M. J

“…In a primate model of Parkinson disease (PD), intrastriatal infusion of an adeno-associated viral (AAV) vector containing the human aromatic l-amino acid…”
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Preliminary evidence that estrogen protects against age-related hippocampal atrophy by Eberling, J.L., Wu, C., Haan, M.N., Mungas, D., Buonocore, M., Jagust, W.J.

“…Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used…”
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Brain structure and cognition in a community sample of elderly latinos by WU, C. C, MUNGAS, D, PETKOV, C. I, EBERLING, J. L, ZRELAK, P. A, BUONOCORE, M. H, BRUNBERG, J. A, HAAN, M. N, JAGUST, W. J

“…Previous studies have found that hippocampal atrophy and white matter hyperintensities (WMH) on MRI are linked to cognitive impairment and dementia. The…”
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Convection-Enhanced Delivery of AAV Vector in Parkinsonian Monkeys; In Vivo Detection of Gene Expression and Restoration of Dopaminergic Function Using Pro-drug Approach by Bankiewicz, Krys S., Eberling, Jamie L., Kohutnicka, Malgorzata, Jagust, William, Pivirotto, Phillip, Bringas, John, Cunningham, Janet, Budinger, Thomas F., Harvey-White, Judith

“…Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter…”
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Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease by Reed, B. R., Eberling, J. L., Mungas, D., Weiner, M. W., Jagust, W. J.

“…Patients with extensive subcortical cerebrovascular disease may have impaired memory, often despite the absence of medial temporal or diencephalic strokes. In…”
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Effect of estrogen on cerebral glucose metabolism in postmenopausal women by EBERLING, J. L, REED, B. R, COLEMAN, J. E, JAGUST, W. J

“…PET was used to evaluate the effect of estrogen use on regional cerebral glucose metabolism in postmenopausal women. Women receiving estrogen replacement…”
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Brain function and cognition in a community sample of elderly latinos by JAGUST, W. J, EBERLING, J. L, WU, C. C, FINKBEINER, A, MUNGAS, D, VALK, P. E, HAAN, M. N

“…Previous studies using PET to measure cerebral glucose metabolism in AD have found metabolic reductions in the temporoparietal and posterior cingulate cortices…”
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Tremor Is Associated with PET Measures of Nigrostriatal Dopamine Function in MPTP-Lesioned Monkeys by Eberling, J.L., Pivirotto, P., Bringas, J., Bankiewicz, K.S.

“…Unilateral intracarotid artery (ICA) MPTP infusion, along with sequential systemic doses of MPTP, produces near complete degeneration of the nigrostriatal…”
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PET studies of functional compensation in a primate model of Parkinsonʼs disease by Eberling, J L, Bankiewicz, K S, Jordan, S, VanBrocklin, H F, Jagust, W J

“…MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is a neurotoxin that produces degeneration of nigrostriatal dopaminergic neurons and a chronic parkinsonian…”
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In vivo PET imaging of gene expression in parkinsonian monkeys by Eberling, J.L., Cunningham, J., Pivirotto, P., Bringas, J., Daadi, M.M., Bankiewicz, K.S.

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Reduced temporal lobe blood flow in Alzheimer's disease by Eberling, J L, Jagust, W J, Reed, B R, Baker, M G

“…We used single photon emission computed tomography with the blood flow tracer [123I]N-isopropyl-p-iodoamphetamine (IMP) to study regional cerebral blood flow…”
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Cerebral Glucose Metabolism and Memory in Aged Rhesus Macaques by Eberling, J.L, Roberts, J.A, Rapp, P.R, Tuszynski, M.H, Jagust, W.J

“…Positron emission tomography and the glucose metabolic tracer [ 18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral…”
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A methodology for specifying PET VOIs using multimodality techniques by Klein, G.J., Teng, X., Jagust, W.J., Eberling, J.L., Acharya, A., Reutter, B.W., Huesman, R.H.

“…Volume-of-interest (VOI) extraction for radionuclide and anatomical measurements requires correct identification and delineation of the anatomical feature…”
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A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes by Eberling, Jamie L., Jagust, William J., Taylor, Scott, Bringas, John, Pivirotto, Phillip, VanBrocklin, Henry F., Bankiewicz, Krys S.

“…Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [ 18 F] 6-fluoro- l- m-tyrosine (FMT) were used to evaluate the relationship…”
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Brain perfusion imaging predicts survival in Alzheimer's disease by JAGUST, W. J, HAAN, M. N, REED, B. R, EBERLING, J. L

“…The variability of disease course in patients diagnosed with AD makes prediction of survival difficult, despite the identification of numerous predictors to…”
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Cortical glucose metabolism in Parkinson's disease without dementia by Eberling, J L, Richardson, B C, Reed, B R, Wolfe, N, Jagust, W J

“…There have been several reports of decreased regional cerebral metabolic rates for glucose (rCMRglc) in Parkinson's disease (PD), although others find no…”
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Human corpus callosum in aging and Alzheimer's disease: a magnetic resonance imaging study by Biegon, A, Eberling, J L, Richardson, B C, Roos, M S, Wong, S T, Reed, B R, Jagust, W J

“…The involvement of the corpus callosum in aging and Alzheimer's disease (AD) is not clear. We measured cross sectional areas of the entire corpus callosum…”
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Iodine-123-5-Iodo-6-Nitroquipazine: SPECT Radiotracer to Image the Serotonin Transporter by Jagust, William J, Eberling, Jamie L, Biegon, Anat, Taylor, Scott E, VanBrocklin, Henry F, Jordan, Shaun, Hanrahan, Stephen M, Roberts, Jeffrey A, Brennan, Kathleen M, Mathis, Chester A

“…Because serotonergic function has been implicated in the pathophysiology of a number of diseases of the nervous system, efforts to image this system in vivo…”
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Dopamine transporter loss and clinical changes in MPTP-lesioned primates by Eberling, Jamie L, Bankiewicz, Krzysztof S, Pivirotto, Phillip, Bringas, John, Chen, Karen, Nowotnik, David P, Steiner, Joseph P, Budinger, Thomas F, Jagust, William J

“…Single photon emission computed tomography (SPECT) and the dopamine (DA) transporter tracer, 2 beta-carboxymethoxy-3 beta-(4-iodophenyl)tropane ([123I]β-CIT),…”
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