Search Results - "EATON, John W."

Nanomaterial cytotoxicity is composition, size, and cell type dependent by Sohaebuddin, Syed K, Thevenot, Paul T, Baker, David, Eaton, John W, Tang, Liping

“…Despite intensive research efforts, reports of cellular responses to nanomaterials are often inconsistent and even contradictory. Additionally, relationships…”
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Titanium dioxide (TiO2) nanoparticles preferentially induce cell death in transformed cells in a Bak/Bax-independent fashion by Zhu, Yanglong, Eaton, John W, Li, Chi

“…While the cytotoxic effects of titanium dioxide (TiO(2)) nanoparticles have been under intense investigation, the molecular mechanisms of this cytotoxicity…”
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Cancer Vaccines: Promising Therapeutics or an Unattainable Dream by Donninger, Howard, Li, Chi, Eaton, John W., Yaddanapudi, Kavitha

“…The advent of cancer immunotherapy has revolutionized the field of cancer treatment and offers cancer patients new hope. Although this therapy has proved…”
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Control of tumor-associated macrophage alternative activation by macrophage migration inhibitory factor by Yaddanapudi, Kavitha, Putty, Kalyani, Rendon, Beatriz E, Lamont, Gwyneth J, Faughn, Jonathan D, Satoskar, Abhay, Lasnik, Amanda, Eaton, John W, Mitchell, Robert A

“…Tumor stromal alternatively activated macrophages are important determinants of antitumor T lymphocyte responses, intratumoral neovascularization, and…”
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Redox activity within the lysosomal compartment: implications for aging and apoptosis by Kurz, Tino, Eaton, John W, Brunk, Ulf T

“…The lysosome is a redox-active compartment containing low-mass iron and copper liberated by autophagic degradation of metalloproteins. The acidic milieu and…”
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Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis by Nagy, Emőke, Eaton, John W, Jeney, Viktória, Soares, Miguel P, Varga, Zsuzsa, Galajda, Zoltán, Szentmiklósi, József, Méhes, Gábor, Csonka, Tamás, Smith, Ann, Vercellotti, Gregory M, Balla, György, Balla, József

“…OBJECTIVE—We investigated whether red cell infiltration of atheromatous lesions promotes the later stages of atherosclerosis. METHODS AND RESULTS—We find that…”
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Haem oxygenase-1 overexpression alters intracellular iron distribution by Lanceta, Lilibeth, Li, Chi, Choi, Augustine M, Eaton, John W

“…Induction or ectopic overexpression of HO-1 (haem oxygenase 1) protects against a wide variety of disorders. These protective effects have been variably…”
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Exosomes from GM-CSF expressing embryonic stem cells are an effective prophylactic vaccine for cancer prevention by Yaddanapudi, Kavitha, Meng, Shuhan, Whitt, Aaron G., Al Rayyan, Numan, Richie, Jamaal, Tu, Allison, Eaton, John W., Li, Chi

“…The antigenic similarity between embryos and tumors has raised the idea of using embryonic material as a preventative vaccine against neoplastic disease…”
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Targeting aspartate aminotransferase in breast cancer by Thornburg, Joshua Marshall, Nelson, Kristin K, Clem, Brian F, Lane, Andrew N, Arumugam, Sengodagounder, Simmons, Allan, Eaton, John W, Telang, Sucheta, Chesney, Jason

“…Glycolysis is increased in breast adenocarcinoma cells relative to adjacent normal cells in order to produce the ATP and anabolic precursors required for…”
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Mitochondrial DNA Damage in Iron Overload by Gao, Xueshan, Campian, Jian Li, Qian, Mingwei, Sun, Xiao-Feng, Eaton, John W.

“…Chronic iron overload has slow and insidious effects on heart, liver, and other organs. Because iron-driven oxidation of most biologic materials (such as…”
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Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment by Balla, József, Vercellotti, Gregory M, Jeney, Viktória, Yachie, Akihiro, Varga, Zsuzsa, Jacob, Harry S, Eaton, John W, Balla, György

“…Iron-derived reactive oxygen species are involved in the pathogenesis of numerous vascular disorders. One abundant source of redox active iron is heme, which…”
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Pro-oxidant and cytotoxic effects of circulating heme by Jeney, Viktória, Balla, József, Yachie, Akihiro, Varga, Zsuzsa, Vercellotti, Gregory M., Eaton, John W., Balla, György

“…Numerous pathologies may involve toxic side effects of free heme and heme-derived iron. Deficiency of the heme-catabolizing enzyme, heme oxygenase-1 (HO-1), in…”
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Heme cytotoxicity is the consequence of endoplasmic reticulum stress in atherosclerotic plaque progression by Pethő, Dávid, Hendrik, Zoltán, Nagy, Annamária, Beke, Lívia, Patsalos, Andreas, Nagy, László, Póliska, Szilárd, Méhes, Gábor, Tóth, Csaba, Potor, László, Eaton, John W., Jacob, Harry S., Balla, György, Balla, József, Gáll, Tamás

“…Hemorrhage and hemolysis with subsequent heme release are implicated in many pathologies. Endothelial cells (ECs) encounter large amount of free heme after…”
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Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice by Jiang, Youchun, Reynolds, Corey, Xiao, Chang, Feng, Wenke, Zhou, Zhanxiang, Rodriguez, Walter, Tyagi, Suresh C, Eaton, John W, Saari, Jack T, Kang, Y. James

“…Sustained pressure overload causes cardiac hypertrophy and the transition to heart failure. We show here that dietary supplementation with physiologically…”
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Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans by Zdolsek, Johann, Eaton, John W, Tang, Liping

“…Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited to implant surfaces. Despite the…”
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How Heme Oxygenase-1 Prevents Heme-Induced Cell Death by Lanceta, Lilibeth, Mattingly, Jacob M, Li, Chi, Eaton, John W

“…Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains…”
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Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible? by Yaddanapudi, Kavitha, Mitchell, Robert A, Putty, Kalyani, Willer, Sharon, Sharma, Rajesh K, Yan, Jun, Bodduluri, Haribabu, Eaton, John W

“…The antigenic similarity between tumors and embryos has been appreciated for many years and reflects the expression of embryonic gene products by cancer cells…”
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Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis by Zhao, Ming, Antunes, Fernando, Eaton, John W., Brunk, Ulf T.

“…Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal rupture followed by apoptosis or necrosis. Enhanced intracellular…”
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Molecular basis of biomaterial-mediated foreign body reactions by Hu, Wen-Jing, Eaton, John W., Ugarova, Tatiana P., Tang, Liping

“…Despite being inert and nontoxic, implanted biomaterials often trigger adverse foreign body reactions such as inflammation, fibrosis, infection, and…”
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CCR9 mediates PI3K/AKT‐dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9‐CCL25 interaction enhances the cytotoxic effects of etoposide by Sharma, Praveen K., Singh, Rajesh, Novakovic, Kristian R., Eaton, John W., Grizzle, William E., Singh, Shailesh

“…Despite recent advances in treatment and management of prostate cancer (PCa), it remains the second leading cause of cancer‐related deaths among men in the US…”
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