SPECIFIC FEATURE OF HORMONAL PROFILE IN PATIENTS WITH PRIMARY AND RECURRENT BREAST CANCER AND THEIR ROLE IN THE EFFICIENCY OF CHEMOTHERAPY

The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and change...

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Bibliographic Details
Published in:	Opukholi zhenskoĭ reproduktivnoĭ sistemy no. 1-2; pp. 29 - 33
Main Authors:	M. B. Kozlova, E. M. Frantziyantz, G. A. Nerodo, R. N. Salatov, R. G. Luganskaya, I. P. Sidorenko, M. V. Kashubina
Format:	Journal Article
Language:	Russian
Published:	ABV-press 01-09-2014
Subjects:	breast cancer chemotherapy hormonal profile recurrence
Online Access:	Get full text
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Summary:	The hormonal background was studied in 32 menopausal patients who had primary breast cancer (Stage III) or its recurrence in the postoperative scar. The patients with the primary process, unlike those with a recurrence, were found to have increased adrenocortical cortisol-forming activity and changed thyroid homeostasis. In both types of the neoplastic process, the blood concentrations of estradi- ol, testosterone, prolactin, follicle-stimulating and luteinizing hormones were disturbed in a substantial number of cases; the distinc- tive feature of the primary process and its recurrence lies in the opposite direction. An association of individual differences in the con- centrations of estradiol and testosterone with the efficiency of neoadjuvant chemotherapy was analyzed in patients with recurrent can- cer.
ISSN:	1994-4098 1999-8627
DOI:	10.17650/1994-4098-2009-0-1-2-29-33