Search Results - "E. E. Korbolina"

Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease by Bryzgalov, Leonid O, Korbolina, Elena E, Merkulova, Tatiana I

“…Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that…”
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Multi-Omics Analysis Revealed the rSNPs Potentially Involved in T2DM Pathogenic Mechanism and Metformin Response by Damarov, Igor S, Korbolina, Elena E, Rykova, Elena Y, Merkulova, Tatiana I

“…The goal of our study was to identify and assess the functionally significant SNPs with potentially important roles in the development of type 2 diabetes…”
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Human-genome single nucleotide polymorphisms affecting transcription factor binding and their role in pathogenesis by Antontseva, E V, Degtyareva, A O, Korbolina, E E, Damarov, I S, Merkulova, T I

“…Single nucleotide polymorphisms (SNPs) are the most common type of variation in the human genome. The vast majority of SNPs identified in the human genome do…”
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Rat retinal transcriptome: Effects of aging and AMD-like retinopathy by Kozhevnikova, Oyuna S., Korbolina, Elena E., Ershov, Nikita I., Kolosova, Natalia G.

“…Pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly, remains poorly understood due to the paucity of animal…”
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The functional insight into the genetics of cardiovascular disease: results from the post-GWAS study by Bryzgalov, L O, Korbolina, E E, Damarov, I S, Merkulova, T I

“…Cardiovascular diseases (CVDs), the leading cause of death worldwide, generally refer to a range of pathological conditions with the involvement of the heart…”
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A Panel of rSNPs Demonstrating Allelic Asymmetry in Both ChIP-seq and RNA-seq Data and the Search for Their Phenotypic Outcomes through Analysis of DEGs by Korbolina, Elena E., Bryzgalov, Leonid O., Ustrokhanova, Diana Z., Postovalov, Sergey N., Poverin, Dmitry V., Damarov, Igor S., Merkulova, Tatiana I.

“…Currently, the detection of the allele asymmetry of gene expression from RNA-seq data or the transcription factor binding from ChIP-seq data is one of the…”
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Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia by Bryzgalov, Leonid O, Korbolina, Elena E, Brusentsov, Ilja I, Leberfarb, Elena Y, Bondar, Natalia P, Merkulova, Tatiana I

“…A challenge of understanding the mechanisms underlying cognition including neurodevelopmental and neuropsychiatric disorders is mainly given by the potential…”
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Development of behavioural dysfunctions in accelerated-senescence OXYS rats is associated with early postnatal alterations in brain phosphate metabolism by Sergeeva, S., Bagryanskaya, E., Korbolina, E., Kolosova, N.

“…We recently demonstrated that senescence-accelerated OXYS rats may represent a model adequate for studying aging processes. The animals of this strain have a…”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as the signs of Alzheimer’s disease development by N. A. Stefanova, E. E. Korbolina, N. I. Ershov, E. I. Rogaev, N. G. Kolosova

“…Alzheimer’s disease (AD) is the most prevalent neuro­degenerative disease. It produces atrophic changes in the brain, which cause dementia. The incidence of AD…”
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Senescence-accelerated OXYS rats: A genetic model of premature aging and age-related diseases by Kolosova, N. G., Stefanova, N. A., Korbolina, E. E., Fursova, A. Zh, Kozhevnikova, O. S.

“…A genetic model of accelerated senescence and the associated diseases in the OXYS strain of rats was established by selection and inbreeding of Wistar rats…”
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RatDNA: DATABASE ON MICROARRAY STUDIES OF RATS BEARING GENES ASSOCIATED WITH AGE-RELATED DISEASES by O. S. Kozhevnikova, M. K. Martyschenko, M. A. Genaev, E. E. Korbolina, N. A. Muraleva, N. G. Kolosova, Y. L. Orlov

“…The purpose of the RatDNA database is the development of experimental methods for basic molecular studies of human age-related diseases in rats involving…”
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Novel approach to functional SNPs discovery from genome‐wide data reveals promising variants for colon cancer risk by Korbolina, Elena E., Brusentsov, Ilja I., Bryzgalov, Leonid O., Leberfarb, Elena Yu, Degtyareva, Arina O., Merkulova, Tatyana I.

“…In the majority of colorectal cancer (CRC) cases, the genetic basis of predisposition remains unexplained. The goal of the study was to assess the regulatory…”
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Senescence-accelerated OXYS rats: A model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease by Stefanova, Natalia, Kozhevnikova, Oyuna, Vitovtov, Anton, Maksimova, Kseniya, Logvinov, Sergey, Rudnitskaya, Ekaterina, Korbolina, Elena, Muraleva, Natalia, Kolosova, Nataliya

“…Senescence-accelerated OXYS rats are an experimental model of accelerated aging that was established from Wistar stock via selection for susceptibility to…”
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Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats by Stefanova, Natalia A, Muraleva, Natalia A, Korbolina, Elena E, Kiseleva, Elena, Maksimova, Kseniya Yi, Kolosova, Nataliya G

“…The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (AD)…”
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Identification of functional networks associated with cell death in the retina of OXYS rats during the development of retinopathy by Telegina, Darya V, Korbolina, Elena E, Ershov, Nikita I, Kolosova, Nataliya G, Kozhevnikova, Oyuna S

“…Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events in AMD is poorly…”
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Association of AMD-like retinopathy development with an Alzheimer’s disease metabolic pathway in OXYS rats by Kozhevnikova, Oyuna S., Korbolina, Elena E., Stefanova, Natalia A., Muraleva, Natalia A., Orlov, Yuriy L., Kolosova, Nataliya G.

“…The main cause of vision loss in older individuals is age-related macular degeneration (AMD)—a complex multifactorial disease, whose etiology and pathogenesis…”
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Application of quantitative trait locus mapping and transcriptomics to studies of the senescence-accelerated phenotype in rats by Korbolina, Elena E, Ershov, Nikita I, Bryzgalov, Leonid O, Kolosova, Natalia G

“…Etiology of complex disorders, such as cataract and neurodegenerative diseases including age-related macular degeneration (AMD), remains poorly understood due…”
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Quantitative trait loci on chromosome 1 for cataract and AMD-like retinopathy in senescence-accelerated OXYS rats by Korbolina, Elena E, Kozhevnikova, Ouyna S, Stefanova, Nataliya A, Kolosova, Natalia G

“…Age-related macular degeneration (AMD) and cataract are common age-related diseases in humans. Previously we showed that senescence-accelerated OXYS rats…”
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Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: analysis by means of congenic strains by Korbolina, Elena E, Zhdankina, Anna A, Fursova, Anzhela Zh, Kozhevnikova, Oyuna S, Kolosova, Natalia G

“…There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To…”
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Changes in the transcriptome of the prefrontal cortex of OXYS rats as signs of the development of Alzheimer’s disease by Stefanova, N. A., Korbolina, E. E., Ershov, N. I., Rogaev, E. I., Kolosova, N. G.

“…Alzheimer’s disease (AD) is the most common neurodegenerative disease. It produces atrophic changes in the brain which cause dementia. The incidence of AD is…”
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