Search Results - "E. Bollard, Mary"

Integrated Metabonomic Analysis of the Multiorgan Effects of Hydrazine Toxicity in the Rat by Garrod, Sarah, Bollard, Mary E, Nicholls, Andrew W, Connor, Susan C, Connelly, John, Nicholson, Jeremy K, Holmes, Elaine

“…Hydrazine is a model toxin that induces both hepatotoxic and neurotoxic effects in experimental animals. The direct biochemical effects of hydrazine in kidney,…”
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NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition by Bollard, Mary E., Stanley, Elizabeth G., Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine

“…Strategies such as genomics, proteomics and metabonomics are being applied with increasing frequency in the pharmaceutical industry. For each of these…”
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Prediction and Classification of Drug Toxicity Using Probabilistic Modeling of Temporal Metabolic Data:  The Consortium on Metabonomic Toxicology Screening Approach by Ebbels, Timothy M. D, Keun, Hector C, Beckonert, Olaf P, Bollard, Mary E, Lindon, John C, Holmes, Elaine, Nicholson, Jeremy K

“…Detection and classification of in vivo drug toxicity is an expensive and time-consuming process. Metabolic profiling is becoming a key enabling tool in this…”
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Improved analysis of multivariate data by variable stability scaling: application to NMR-based metabolic profiling by Keun, Hector C., Ebbels, Timothy M.D., Antti, Henrik, Bollard, Mary E., Beckonert, Olaf, Holmes, Elaine, Lindon, John C., Nicholson, Jeremy K.

“…Variable scaling alters the covariance structure of data, affecting the outcome of multivariate analysis and calibration. Here we present a new method,…”
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NMR-based metabonomic toxicity classification: hierarchical cluster analysis and k-nearest-neighbour approaches by Beckonert, Olaf, E. Bollard, Mary, Ebbels, Timothy M.D, Keun, Hector C, Antti, Henrik, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…The COnsortium for MEtabonomic Toxicology (COMET) project is constructing databases and metabolic models of drug toxicity using ca. 100,000 1 H NMR spectra of…”
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Comparative metabonomics of differential hydrazine toxicity in the rat and mouse by Bollard, Mary E., Keun, Hector C., Beckonert, Olaf, Ebbels, Tim M.D., Antti, Henrik, Nicholls, Andrew W., Shockcor, John P., Cantor, Glenn H., Stevens, Greg, Lindon, John C., Holmes, Elaine, Nicholson, Jeremy K.

“…Interspecies variation between rats and mice has been studied for hydrazine toxicity using a novel metabonomics approach. Hydrazine hydrochloride was…”
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NMR-Based Metabolic Profiling Identifies Biomarkers of Liver Regeneration Following Partial Hepatectomy in the Rat by Bollard, Mary E, Contel, Nancy R, Ebbels, Timothy M. D, Smith, Leon, Beckonert, Olaf, Cantor, Glenn H, Lehman-McKeeman, Lois, Holmes, Elaine C, Lindon, John C, Nicholson, Jeremy K, Keun, Hector C

“…Tissue injury and repair are often overlapping consequences of disease or toxic exposure, but are not often considered as distinct processes in molecular…”
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Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis by Lindon, John C., Holmes, Elaine, Bollard, Mary E., Stanley, Elizabeth G., Nicholson, Jeremy K.

“…In this review, metabonomics, a combination of data-rich analytical chemical measurements and chemometrics for profiling metabolism in complex systems, is…”
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Analytical reproducibility in (1)H NMR-based metabonomic urinalysis by Keun, Hector C, Ebbels, Timothy M D, Antti, Henrik, Bollard, Mary E, Beckonert, Olaf, Schlotterbeck, Götz, Senn, Hans, Niederhauser, Urs, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…Metabonomic analysis of biofluids and tissues utilizing high-resolution NMR spectroscopy and chemometric techniques has proven valuable in characterizing the…”
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Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project by Lindon, John C, Nicholson, Jeremy K, Holmes, Elaine, Antti, Henrik, Bollard, Mary E, Keun, Hector, Beckonert, Olaf, Ebbels, Timothy M, Reily, Michael D, Robertson, Donald, Stevens, Gregory J, Luke, Peter, Breau, Alan P, Cantor, Glenn H, Bible, Roy H, Niederhauser, Urs, Senn, Hans, Schlotterbeck, Goetz, Sidelmann, Ulla G, Laursen, Steen M, Tymiak, Adrienne, Car, Bruce D, Lehman-McKeeman, Lois, Colet, Jean-Marie, Loukaci, Ali, Thomas, Craig

“…The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented here together with a brief summary of published studies. To…”
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Geometric Trajectory Analysis of Metabolic Responses To Toxicity Can Define Treatment Specific Profiles by Keun, Hector C, Ebbels, Timothy M. D, Bollard, Mary E, Beckonert, Olaf, Antti, Henrik, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…Metabonomics can be viewed as the process of defining multivariate metabolic trajectories that describe the systemic response of organisms to physiological…”
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Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues by Wang, Yulan, Bollard, Mary E., Keun, Hector, Antti, Henrik, Beckonert, Olaf, Ebbels, Timothy M., Lindon, John C., Holmes, Elaine, Tang, Huiru, Nicholson, Jeremy K.

“…Principal component analysis (PCA) has been applied to three nuclear magnetic resonance (NMR) spectral editing methods, namely, the Carr–Purcell–Meiboom–Gill…”
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Metabolic Profiling of the Effects of d-Galactosamine in Liver Spheroids Using 1H NMR and MAS-NMR Spectroscopy by Bollard, Mary E, Xu, Jinsheng, Purcell, Wendy, Griffin, Julian L, Quirk, Christopher, Holmes, Elaine, Nicholson, Jeremy K

“…We report here the combined application of 1H magic angle spinning (MAS) and high-resolution NMR spectroscopy and pattern recognition methods to study the…”
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Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy by Bollard, Mary E, Xu, Jinsheng, Purcell, Wendy, Griffin, Julian L, Quirk, Christopher, Holmes, Elaine, Nicholson, Jeremy K

“…We report here the combined application of (1)H magic angle spinning (MAS) and high-resolution NMR spectroscopy and pattern recognition methods to study the…”
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Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships by Mitchell, Stephen C, Bollard, Mary E, Zhang, AiQin

“…Abstract The relationships between several small molecular weight aliphatic amines (methylamine, dimethylamine, trimethylamine, and ethylamine) and an…”
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Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague–Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition by Wang, Yulan, Bollard, Mary E., Nicholson, Jeremy K., Holmes, Elaine

“…Mercury II chloride (HgCl 2) toxicity was investigated in Sprague–Dawley rats using high-resolution magic angle spinning (HRMAS) 1H NMR spectroscopy in…”
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Analytical Reproducibility in 1H NMR-Based Metabonomic Urinalysis by Keun, Hector C, Ebbels, Timothy M. D, Antti, Henrik, Bollard, Mary E, Beckonert, Olaf, Schlotterbeck, Götz, Senn, Hans, Niederhauser, Urs, Holmes, Elaine, Lindon, John C, Nicholson, Jeremy K

“…Metabonomic analysis of biofluids and tissues utilizing high-resolution NMR spectroscopy and chemometric techniques has proven valuable in characterizing the…”
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Statistical experimental design and partial least squares regression analysis of biofluid metabonomic NMR and clinical chemistry data for screening of adverse drug effects by Antti, Henrik, Ebbels, Timothy M.D., Keun, Hector C., Bollard, Mary E., Beckonert, Olaf, Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine

“…Metabonomic analysis is increasingly recognised as a powerful approach for delineating the integrated metabolic changes in biofluids and tissues due to…”
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NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition: METABONOMIC CHARACTERIZATION OF PHYSIOLOGICAL VARIATION by Bollard, Mary E., Stanley, Elizabeth G., Lindon, John C., Nicholson, Jeremy K., Holmes, Elaine

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Metabolic Profiling of the Effects of d -Galactosamine in Liver Spheroids Using 1 H NMR and MAS-NMR Spectroscopy by Bollard, Mary E., Xu, Jinsheng, Purcell, Wendy, Griffin, Julian L., Quirk, Christopher, Holmes, Elaine, Nicholson, Jeremy K.

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