Search Results - "E Voll"

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis by Hakkim, Abdul, Fürnrohr, Barbara G, Amann, Kerstin, Laube, Britta, Abed, Ulrike Abu, Brinkmann, Volker, Herrmann, Martin, Voll, Reinhard E, Zychlinsky, Arturo

“…Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients develop autoantibodies to DNA, histones, and often to neutrophil proteins. These…”
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The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus by Alexander, Tobias, Sarfert, Ramona, Klotsche, Jens, Kühl, Anja A, Rubbert-Roth, Andrea, Lorenz, Hannes-Martin, Rech, Jürgen, Hoyer, Bimba F, Cheng, Qingyu, Waka, Aderajew, Taddeo, Adriano, Wiesener, Michael, Schett, Georg, Burmester, Gerd-Rüdiger, Radbruch, Andreas, Hiepe, Falk, Voll, Reinhard E

“…To investigate whether bortezomib, a proteasome inhibitor approved for treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in…”
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High‐mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus by Urbonaviciute, V., Voll, R. E.

“…  Urbonaviciute V, Voll RE (Friedrich‐Alexander University of Erlangen‐Nuremberg, Erlangen; and University Medical Centre Freiburg, Freiburg/Breisgau;…”
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B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients by Thiel, Jens, Rizzi, Marta, Engesser, Marie, Dufner, Ann-Kathrin, Troilo, Arianna, Lorenzetti, Raquel, Voll, Reinhard E, Venhoff, Nils

“…B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been…”
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Increased binding of anti-dsDNA antibodies to short oligonucleotides modified with topoisomerase I reveals a potential new enzyme function independent from DNA relaxation by Frese-Schaper, Manuela, Voll, Reinhard E, Frese, Steffen

“…Topoisomerase I (topo I) is a highly conserved enzyme which is known to reduce torsional stress at double-stranded (ds) DNA. Torsional stress induced by…”
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Pathogenesis of autoimmunity in common variable immunodeficiency by Warnatz, Klaus, Voll, Reinhard E

“…Common variable immunodeficiency (CVID) presents in up to 25% of patients with autoimmune (AI) manifestations. Given the frequency and early onset in some…”
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Favourable outcome of acute hepatitis E infection in patients with ANCA-associated vasculitis by Zeisbrich, Markus, Wendel, Sarah, Finzel, Stephanie, Voll, Reinhard E, Venhoff, Nils

“…Hepatitis E virus (HEV) infection is a frequent cause of acute viral hepatitis. Immunocompromised patients are at increased risk for viral infection and…”
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Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE by Urbonaviciute, Vilma, Fürnrohr, Barbara G, Meister, Silke, Munoz, Luis, Heyder, Petra, De Marchis, Francesco, Bianchi, Marco E, Kirschning, Carsten, Wagner, Hermann, Manfredi, Angelo A, Kalden, Joachim R, Schett, Georg, Rovere-Querini, Patrizia, Herrmann, Martin, Voll, Reinhard E

“…Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved…”
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Streptobacillus moniliformis and IgM and IgG Immune Response in Patient with Endocarditis by Mathe, Philipp, Schmidt, Katja, Schindler, Viktoria, Fawzy, Ahmad, Schultze, Tilman, Voll, Reinhard E, Pauli, David, Popova, Milena, Schauer, Franziska, Eisenberg, Tobias

“…We describe a case of endocarditis caused by Streptobacillus moniliformis bacteria, a known cause of rat-bite fever, in a 32-year-old woman with pet rats in…”
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Factors masking HMGB1 in human serum and plasma by Urbonaviciute, Vilma, Fürnrohr, Barbara G., Weber, Christian, Haslbeck, Martin, Wilhelm, Sabine, Herrmann, Martin, Voll, Reinhard E.

“…High mobility group box 1 protein (HMGB1) is a ubiquitously expressed architectural chromosomal protein. Recently, it has become obvious that HMGB1 can also…”
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Circulating multimeric immune complexes contribute to immunopathology in COVID-19 by Ankerhold, Jakob, Giese, Sebastian, Kolb, Philipp, Maul-Pavicic, Andrea, Voll, Reinhard E., Göppert, Nathalie, Ciminski, Kevin, Kreutz, Clemens, Lother, Achim, Salzer, Ulrich, Bildl, Wolfgang, Welsink, Tim, Morgenthaler, Nils G., Grawitz, Andrea Busse, Emmerich, Florian, Steinmann, Daniel, Huzly, Daniela, Schwemmle, Martin, Hengel, Hartmut, Falcone, Valeria

“…A dysregulated immune response with high levels of SARS-CoV-2 specific IgG antibodies characterizes patients with severe or critical COVID-19. Although a…”
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Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases by Sehnert, Bettina, Burkhardt, Harald, Dübel, Stefan, Voll, Reinhard E

“…Deregulated NF-k activation is not only involved in cancer but also contributes to the pathogenesis of chronic inflammatory diseases like rheumatoid arthritis…”
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CMTM6-Deficient Monocytes in ANCA-Associated Vasculitis Fail to Present the Immune Checkpoint PD-L1 by Zeisbrich, Markus, Chevalier, Nina, Sehnert, Bettina, Rizzi, Marta, Venhoff, Nils, Thiel, Jens, Voll, Reinhard E.

“…ObjectivesANCA-associated vasculitides (AAV) affect small- and medium-sized blood vessels. In active disease, vessel wall infiltrates are mainly composed of…”
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Machine learning for precision diagnostics of autoimmunity by Kruta, Jan, Carapito, Raphael, Trendelenburg, Marten, Martin, Thierry, Rizzi, Marta, Voll, Reinhard E., Cavalli, Andrea, Natali, Eriberto, Meier, Patrick, Stawiski, Marc, Mosbacher, Johannes, Mollet, Annette, Santoro, Aurelia, Capri, Miriam, Giampieri, Enrico, Schkommodau, Erik, Miho, Enkelejda

“…Early and accurate diagnosis is crucial to prevent disease development and define therapeutic strategies. Due to predominantly unspecific symptoms, diagnosis…”
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Impact of rituximab on immunoglobulin concentrations and B cell numbers after cyclophosphamide treatment in patients with ANCA-associated vasculitides by Venhoff, Nils, Effelsberg, Nora M, Salzer, Ulrich, Warnatz, Klaus, Peter, Hans Hartmut, Lebrecht, Dirk, Schlesier, Michael, Voll, Reinhard E, Thiel, Jens

“…To assess the impact of immunosuppressive therapy with cyclophosphamide (CYC) and rituximab (RTX) on serum immunoglobulin (Ig) concentrations and B lymphocyte…”
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Impact of tofacitinib treatment on human B-cells in vitro and in vivo by Rizzi, Marta, Lorenzetti, Raquel, Fischer, Kathleen, Staniek, Julian, Janowska, Iga, Troilo, Arianna, Strohmeier, Valentina, Erlacher, Miriam, Kunze, Mirjam, Bannert, Bettina, Kyburz, Diego, Voll, Reinhard E, Venhoff, Nils, Thiel, Jens

“…Abstract B-cells are pivotal to the pathogenesis of rheumatoid arthritis and tofacitinib, a JAK inhibitor, is effective and safe in its treatment. Tofacitinib…”
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Older age, comorbidity, glucocorticoid use and disease activity are risk factors for COVID-19 hospitalisation in patients with inflammatory rheumatic and musculoskeletal diseases by Hasseli, Rebecca, Mueller-Ladner, Ulf, Hoyer, Bimba F, Krause, Andreas, Lorenz, Hanns-Martin, Pfeil, Alexander, Richter, Jutta, Schäfer, Martin, Schmeiser, Tim, Strangfeld, Anja, Schulze-Koops, Hendrik, Voll, Reinhard E, Specker, Christof, Regierer, Anne Constanze

“…IntroductionWhether patients with inflammatory rheumatic and musculoskeletal diseases (RMD) are at higher risk to develop severe courses of COVID-19 has not…”
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JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis by Frede, Natalie, Lorenzetti, Raquel, Hüppe, Janika M, Janowska, Iga, Troilo, Arianna, Schleyer, Marei-Theresa, Venhoff, Ana C, Voll, Reinhard E, Thiel, Jens, Venhoff, Nils, Rizzi, Marta

“…Janus kinase (JAK) inhibitors have been approved for the treatment of several immune-mediated diseases (IMIDs) including rheumatoid arthritis (RA) and…”
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Inflammatory stays inflammatory: a subgroup of systemic sclerosis characterized by high morbidity and inflammatory resistance to cyclophosphamide by Mitev, Aleksey, Christ, Lisa, Feldmann, Daria, Binder, Moritz, Möller, Kim, Kanne, Anna-Maria, Hügle, Thomas, Villiger, Peter M, Voll, Reinhard E, Finzel, Stephanie, Kollert, Florian

“…Elevated levels of C-reactive protein (CRP) in systemic sclerosis (SSc) have been linked to early inflammatory stages of the disease. This study has been…”
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Naive- and Memory-like CD21low B Cell Subsets Share Core Phenotypic and Signaling Characteristics in Systemic Autoimmune Disorders by Freudenhammer, Mirjam, Voll, Reinhard E., Binder, Sebastian C., Keller, Baerbel, Warnatz, Klaus

“…An expansion of CD21low B cells has been described in a variety of diseases associated with persistent immune stimulation as in chronic infection,…”
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