Search Results - "E Knight, Jr"

Immunoregulatory properties of ISG15, an interferon-induced cytokine by J D'Cunha, E Knight, Jr, A L Haas, R L Truitt, E C Borden

“…ISG15 is a 15-kDa protein of unique primary amino acid sequence, which is transcriptionally regulated by interferon (IFN) alpha and IFN-beta. Because it is…”
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In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine by D'Cunha, J, Ramanujam, S, Wagner, RJ, Witt, PL, Knight, E, Jr, Borden, EC

“…ISG15, a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homologue and a cytokine that induces production of…”
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A human 15-kDa IFN-induced protein induces the secretion of IFN-gamma by Recht, M, Borden, EC, Knight, E, Jr

“…A 15,000 molecular weight protein (15-kDa), induced and secreted by human PBMC after treatment with IFN-alpha or -beta, was assessed for its ability to…”
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IFN-induced 15-kDa protein is released from human lymphocytes and monocytes by Knight, E, Jr, Cordova, B

“…The enhancement or inhibition of synthesis of specific proteins by IFN is believed to cause subsequent IFN-induced biological responses. The roles of most of…”
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Interferon-Induced Transcription of a Gene Encoding a 15-kDa Protein Depends on an Upstream Enhancer Element by Reich, N., Evans, B., Levy, D., Fahey, D., Knight, E., Darnell, J. E.

“…A human gene encoding an interferon-induced 15-kDa protein has been isolated from a genomic library. The gene appears to be single-copy and is composed of two…”
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Fused Pyrrolo[2,3-c]carbazol-6-ones:  Novel Immunostimulants That Enhance Human Interferon-γ Activity by Hudkins, Robert L, Diebold, James L, Angeles, Thelma S, Knight, Ernest

“…The clinical need for therapeutic agents which restore or enhance an immune response in immunocompromised patients such as occurs in viral infections, cancer,…”
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Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway by Maroney, Anna C, Glicksman, Marcie A, Basma, Alie N, Walton, Kevin M, Knight, Ernest, Jr, Murphy, Carol A, Bartlett, Becky A, Finn, James P, Angeles, Thelma, Matsuda, Yuzuru, Neff, Nicola T, Dionne, Craig A

“…Neurons undergoing apoptosis can be rescued by trophic factors that simultaneously increase the activity of extracellular signal-regulated kinase (ERK) and…”
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Interferon Regulates c-myc Gene Expression in Daudi Cells at the Post-Transcriptional Level by Knight, E., Anton, E. D., Fahey, D., Friedland, B. K., Jonak, G. J.

“…c-myc gene mRNA is reduced by >75% in the human lymphoblastoid cell line Daudi when growth is inhibited by treatment with human interferon β (IFN-β ). In the…”
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Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence by Blomstrom, D C, Fahey, D, Kutny, R, Korant, B D, Knight, E

“…We have isolated a cDNA clone for an interferon-induced 15-kDa protein. The cDNA clone was prepared from mRNA isolated from interferon-beta-treated human Daudi…”
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A 15-kDa interferon-induced protein is derived by COOH-terminal processing of a 17-kDa precursor by Knight, E, Fahey, D, Cordova, B, Hillman, M, Kutny, R, Reich, N, Blomstrom, D

“…An interferon-induced 15-kDa protein is synthesized from a precursor of higher molecular weight; the precursor contains 165 amino acids (17 kDa), whereas the…”
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Selective Reduction of c-myc mRNA in Daudi Cells by Human β Interferon by Jonak, G. J., Knight, E.

“…Under normal growth conditions, the human lymphoblastoid cell line Daudi expresses high levels of c-myc mRNA. These cells are also sensitive to growth…”
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Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon by Korant, B D, Blomstrom, D C, Jonak, G J, Knight, E

“…Human interferons induce a protein of 15,000 daltons in human and bovine cells. This protein is located in the cytoplasm in a soluble form and is induced by…”
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A growth inhibitory protein secreted by human diploid fibroblasts. Partial purification and characterization by Feltham, N., Fahey, D., Knight, E.

“…We have identified and partially purified a growth inhibitor protein secreted by human diploid fibroblast cells. This protein is not secreted constitutively…”
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Antibodies to synthetic peptides of human interferon-beta. Use in biosynthetic studies by T P Chow, W F DeGrado, E Knight, Jr

“…Two peptides from the amino terminus of human interferon-beta were synthesized corresponding to amino acids 1-21 and 18-45. The peptides were conjugated to…”
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Interferon: Purification and Initial Characterization from Human Diploid Cells by Knight, Ernest

“…Interferon produced by human diploid fibroblast cells in culture has been purified approximately 5000-fold. The purified interferon, when analyzed by…”
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Production and characterization of recombinant mouse brain-derived neurotrophic factor and rat neurotrophin-3 expressed in insect cells by Meyer, S L, Lang, D M, Forbes, M E, Knight, Jr, E, Hirsch, J D, Trusko, S P, Scott, R W

“…Bioactive brain-derived neurotrophic factor (BDNF) and neurotrophin-3 were produced using the baculovirus expression system and purified to homogeneity using…”
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Heterogeneity of purified mouse interferons by E Knight, Jr

“…A procedure for obtaining highly purified stable interferon from mouse L cells is described. Interferon with a specific activity of 2.5 times 10-8 reference…”
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Human fibroblast interferon. An improved purification by E Knight, Jr, D Fahey

“…Human fibroblast interferon has been purified 2,900-fold to homogeneity. The purification is achieved in two steps by chromatography on blue Sepharose. The…”
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Fibroblast Interferon Induces Synthesis of Four Proteins in Human Fibroblast Cells by Knight, Ernest, Korant, Bruce D.

“…Treatment of human diploid fibroblasts with fibroblast interferon for 8 hr inhibited replication of vesicular stomatitis virus. When the total cell protein of…”
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Human Fibroblast Interferon: Amino Acid Analysis and Amino Terminal Amino Acid Sequence by Knight, E., Hunkapiller, M. W., Korant, B. D., Hardy, R. W. F., Hood, L. E.

“…The purification of human fibroblast interferon has been simplified to a two-step procedure consisting of affinity chromatography on Blue Sepharose and sodium…”
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