Search Results - "E Kövér, Katalin"
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Expedited Nuclear Magnetic Resonance Assignment of Small- to Medium-Sized Molecules with Improved HSQC−CLIP−COSY Experiments
Published in Analytical chemistry (Washington) (16-02-2021)“…Resonance assignment is a pivotal step for any nuclear magnetic resonance (NMR) analysis, such as structure elucidation or the investigation of protein–ligand…”
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Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3
Published in International journal of molecular sciences (24-02-2022)“…Human galectin-3 ( Gal-3) is involved in a variety of biological processes and is implicated in wide range of diseases. As a result, targeting Gal-3 for…”
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3
NORD: NO Relaxation Delay NMR Spectroscopy
Published in Angewandte Chemie International Edition (07-06-2021)“…The novel concept of NORD (NO relaxation delay) NMR spectroscopy is introduced. The idea is to design concatenated experiments in a way that the magnetization…”
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Comparison of Carbohydrate Force Fields Using Gaussian Accelerated Molecular Dynamics Simulations and Development of Force Field Parameters for Heparin-Analogue Pentasaccharides
Published in Journal of chemical information and modeling (25-11-2019)“…Computational description of conformational and dynamic properties of anticoagulant heparin analogue pentasaccharides is of crucial importance in understanding…”
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Synthesis of a Heparinoid Pentasaccharide Containing l‑Guluronic Acid Instead of l‑Iduronic Acid with Preserved Anticoagulant Activity
Published in Journal of organic chemistry (02-12-2022)“…l-Iduronic acid is a key constituent of heparin and heparan sulfate polysaccharides due to its unique conformational plasticity, which facilitates the binding…”
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Four-in-one: HSQC, HSQC-TOCSY (or H2BC), TOCSY, and enhanced HMBC spectra integrated into a single NO Relaxation Delay (NORD) NMR experiment
Published in Journal of magnetic resonance (1997) (01-10-2022)“…[Display omitted] •New three-module NORD experiments deliver four spectra, including HMBC, HSQC, TOCSY, and either HSQC-TOCSY or H2BC.•A homonuclear TOCSY…”
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Conformational Analysis of Heparin-Analogue Pentasaccharides by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulations
Published in Journal of chemical information and modeling (28-06-2021)“…Elucidation and improvement of the blood coagulant properties of heparin are the focus of intense research. In this study, we performed conformational analysis…”
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Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis
Published in Nature communications (10-03-2023)“…During muscle cell differentiation, the alternatively spliced, acidic β-domain potentiates transcription of Myocyte-specific Enhancer Factor 2 (Mef2D)…”
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Double and adiabatic BANGO for concatenating two NMR experiments relying on the same pool of magnetization
Published in Journal of magnetic resonance (1997) (01-07-2020)“…[Display omitted] •Concatenated experiments with single relaxation delay deliver full H/C correlations.•Double application of BANGO pulse allows to tap same…”
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DMSO-Induced Unfolding of the Antifungal Disulfide Protein PAF and Its Inactive Variant: A Combined NMR and DSC Study
Published in International journal of molecular sciences (07-01-2023)“…PAF and related antifungal proteins are promising antimicrobial agents. They have highly stable folds around room temperature due to the presence of 3-4…”
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Synergy and sensitivity-balance in concatenating experiments in NO relaxation delay NMR (NORD)
Published in Chemical communications (Cambridge, England) (17-02-2022)“…The NMR experiment design strategy of NO Relaxation Delay (NORD), introduced mostly as an idealized theoretical approach, is extended and put to practical use…”
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Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1
Published in International journal of molecular sciences (01-03-2023)“…Identification of specific protein phosphatase-1 (PP1) inhibitors is of special importance regarding the study of its cellular functions and may have…”
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Multifaceted Domino Knoevenagel‐Cyclization Reactions; Four Movements for 2H‐Chromenes and Chromans
Published in Advanced synthesis & catalysis (13-10-2023)“…Domino Knoevenagel‐cyclization reactions of 2H‐chromene and chroman derivatives containing o‐formylaryl amine or ether side‐chain was carried out to produce…”
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Thio- and selenoglycosides as ligands for biomedically relevant lectins: Valency–activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides
Published in Bioorganic & medicinal chemistry letters (15-02-2015)“…[Display omitted] Substitution of the oxygen atom in the glycosidic linkage by a disulfide bond or by selenium makes the resulting glycoside resistant to…”
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PSYCHE CPMG-HSQMBC: An NMR Spectroscopic Method for Precise and Simple Measurement of Long-Range Heteronuclear Coupling Constants
Published in Chemistry : a European journal (28-09-2015)“…Among the NMR spectroscopic parameters, long‐range heteronuclear coupling constants convey invaluable information on torsion angles relevant to glycosidic…”
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Replacement of the L-iduronic acid unit of the anticoagulant pentasaccharide idraparinux by a 6-deoxy-L-talopyranose – Synthesis and conformational analysis
Published in Scientific reports (13-09-2018)“…One critical part of the synthesis of heparinoid anticoagulants is the creation of the L-iduronic acid building block featured with unique conformational…”
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Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8′-Linked 9,10-Phenanthrenequinone Dimers
Published in Journal of natural products (Washington, D.C.) (28-02-2020)“…In a search for new secondary metabolites from mosses, leucobryns A–E, axially chiral 9,10-phenanthrenequinone dimers, were isolated from Paraleucobryum…”
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Synthesis of Tetravalent Thio- and Selenogalactoside-Presenting Galactoclusters and Their Interactions with Bacterial Lectin PA-IL from Pseudomonas aeruginosa
Published in Molecules (Basel, Switzerland) (21-01-2021)“…Synthesis of tetravalent thio- and selenogalactopyranoside-containing glycoclusters using azide-alkyne click strategy is presented. Prepared compounds are…”
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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity
Published in International journal for parasitology -- drugs and drug resistance (01-04-2024)“…Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly…”
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The First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin
Published in Pharmaceuticals (Basel, Switzerland) (08-01-2022)“…Various dimeric derivatives of the glycopeptide antibiotic teicoplanin were prepared with the aim of increasing the activity of the parent compound against…”
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