Co-administration of either curcumin or resveratrol with cisplatin treatment decreases hepatotoxicity in rats via anti-inflammatory and oxidative stress-apoptotic pathways

Cisplatin (CIS) is a broad-spectrum anticancer drug, with cytotoxic effects on either malignant or normal cells. We aimed to evaluate the hepatotoxicity in rats caused by CIS and its amelioration by the co-administration of either curcumin or resveratrol. Forty adult male rats divided into four equa...

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Published in:	PeerJ (San Francisco, CA) Vol. 12; p. e17687
Main Authors:	Ramadan, Osama I, S Ali, Lashin, M Abd-Allah, Fatma, E A Ereba, Rafik, S Humeda, Humeda, A Damanhory, Ahmed, E Moustafa, Ahmed, M Younes, Amr, M Y Awad, Moaaz, A A Omar, Nassar
Format:	Journal Article
Language:	English
Published:	United States PeerJ. Ltd 22-07-2024 PeerJ Inc
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-inflammatory drugs Anticancer Antimitotic agents Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - toxicity Antioxidants - administration & dosage Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Bilirubin Biochemistry Cancer Care and treatment Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Cisplatin Cisplatin - administration & dosage Cisplatin - toxicity Curcumin Curcumin - administration & dosage Curcumin - pharmacology Dosage and administration Hepatotoxicity Histology Liver Liver - drug effects Liver - metabolism Liver - pathology Male Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Resveratrol Resveratrol - administration & dosage Resveratrol - pharmacology Stilbenes - administration & dosage Stilbenes - pharmacology Stilbenes - therapeutic use Toxicology Egypt Curcumin Anticancer Hepatotoxicity Cisplatin Resveratrol
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Summary:	Cisplatin (CIS) is a broad-spectrum anticancer drug, with cytotoxic effects on either malignant or normal cells. We aimed to evaluate the hepatotoxicity in rats caused by CIS and its amelioration by the co-administration of either curcumin or resveratrol. Forty adult male rats divided into four equal groups: (control group): rats were given a saline solution (0.9%) once intraperitoneally, daily for the next 28 days; (cisplatin group): rats were given a daily oral dose of saline solution (0.9%) for 28 days after receiving a single dose of cisplatin (3.3 mg/kg) intraperitoneally for three successive days; (CIS plus curcumin/resveratrol groups): rats received the same previous dose of cisplatin (3.3 mg/kg) daily for three successive days followed by oral administration of either curcumin/resveratrol solution at a dose of (20 mg/kg) or (10 mg/kg) consequently daily for 28 days. Different laboratory tests (ALT, AST, ALP, bilirubin, oxidative stress markers) and light microscopic investigations were done. Administration of CIS resulted in hepatotoxicity in the form of increased liver enzymes, oxidative stress markers; degenerative and apoptotic changes, the co-administration of CIS with either curcumin or resveratrol improved hepatotoxicity through improved microscopic structural changes, reduction in liver enzymes activity, decreased oxidative stress markers, improved degenerative, and apoptotic changes in liver tissues. Co-administration of either curcumin or resveratrol with cisplatin treatment could ameliorate hepatotoxicity caused by cisplatin in rats anti-inflammatory and oxidative stress-apoptotic pathways.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2167-8359 2167-8359
DOI:	10.7717/peerj.17687