Search Results - "Dziwornu, Godwin"

Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin by Watson, Daniel J, Meyers, Paul R, Acquah, Kojo Sekyi, Dziwornu, Godwin A, Barnett, Christopher Bevan, Wiesner, Lubbe

“…With drug resistance threatening our first line antimalarial treatments, novel chemotherapeutics need to be developed. Ionophores have garnered interest as…”
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Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents by Vinindwa, Bonani, Dziwornu, Godwin Akpeko, Masamba, Wayiza

“…Molecular hybridization is a drug discovery strategy that involves the rational design of new chemical entities by the fusion (usually via a covalent linker)…”
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Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum by Chama, Mary A., Dziwornu, Godwin A., Popli, Elizabeth, Mas-Claret, Eduard, Egyir, Beverly, Ayine-Tora, Daniel M., Owusu, Kofi B-A., Reid, David G., Osei-Safo, Dorcas, Duer, Melinda, Mulholland, Dulcie, Bender, Andreas

“…Here we report a new polyhydroxylated triterpene, 2β,6β,21α-trihydroxyfriedelan-3-one (4) isolated from the root and stem bark of Dichapetalum albidum A. Chev…”
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Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis by Dziwornu, Godwin A, Caira, Mino R, Mare, Jo-Anne de la, Edkins, Adrienne L, Bolton, John J, Beukes, Denzil R, Sunassee, Suthananda N

“…The marine red algae of the genus have been widely studied for their structurally diverse and biologically active secondary metabolites. We report here the…”
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Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean by Olsen, Elisabeth K, de Cerf, Christopher K, Dziwornu, Godwin A, Puccinelli, Eleonora, Ansorge, Isabelle J, Samaai, Toufiek, Dingle, Laura M.K, Edkins, Adrienne L, Sunassee, Suthananda N

“…Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the…”
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Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin by Dziwornu, Godwin Akpeko, Kamunya, Stephanie, Ntsabo, Tando, Chibale, Kelly

“…Fusidic acid is a natural product antibiotic used clinically, primarily against staphylococcal infections. It has also exhibited antimycobacterial activity…”
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Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity by Osei-Safo, Dorcas, Dziwornu, Godwin Akpeko, Appiah-Opong, Regina, Chama, Mary Anti, Tuffour, Isaac, Waibel, Reiner, Amewu, Richard, Addae-Mensah, Ivan

“…As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, ,…”
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New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara) by Uushona, Nashipolo E., Dziwornu, Godwin A., Mkwanazi, Nonkululeko, Kaschula, Catherine H., Sunassee, Suthananda N., de Villiers, André

“…Acanthosicyos horridus Welw. ex Hook.f. (!nara) is a leafless, thorny, melon-producing plant endemic to the hyper-arid Namib Desert. The methanol crude extract…”
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Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present) by Cheuka, Peter Mubanga, Dziwornu, Godwin, Okombo, John, Chibale, Kelly

“…Plasmepsins represent novel antimalarial drug targets. However, plasmepsin-based antimalarial drug discovery efforts in the past 2 decades have generally…”
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The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives by Addae-Mensah, Ivan, Dziwornu, Godwin Akpeko, Chama, Mary Anti, Osei-Safo, Dorcas

“…Covering mainly from 2013 up to 2023 with relevant references to work done before 2013First reported in 1995, the dichapetalins and analogous compounds…”
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The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics by Singh, Vinayak, Dziwornu, Godwin Akpeko, Chibale, Kelly

“…Drug metabolism is generally associated with liver enzymes. However, in the case of Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis…”
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Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity by Singh, Kawaljit, Kaur, Gurminder, Shanika, Petrus Siningu, Dziwornu, Godwin Akpeko, Okombo, John, Chibale, Kelly

“…[Display omitted] Fusidic acid (FA) is a potent congener of the fusidane triterpenoid class of antibiotics. Structure-activity relationship (SAR) studies…”
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Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis by Singh, Vinayak, Dziwornu, Godwin Akpeko, Mabhula, Amanda, Chibale, Kelly

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health concern given the increase in multiple forms of drug-resistant TB. This…”
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Another decade of antimalarial drug discovery: New targets, tools and molecules by Woodland, John G, Horatscheck, André, Soares de Melo, Candice, Dziwornu, Godwin A, Taylor, Dale

“…Malaria remains a devastating but preventable infectious disease that disproportionately affects the African continent. Emerging resistance to current…”
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Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here? by Dziwornu, Godwin Akpeko, Attram, Henrietta Dede, Gachuhi, Samuel, Chibale, Kelly

“…Globally, schistosomiasis threatens more than 700 million lives, mostly children, in poor localities of tropical and sub-tropical areas with morbidity due to…”
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Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies by Dziwornu, Godwin Akpeko, Coertzen, Dina, Leshabane, Meta, Korkor, Constance M, Cloete, Cleavon K, Njoroge, Mathew, Gibhard, Liezl, Lawrence, Nina, Reader, Janette, van der Watt, Mariëtte, Wittlin, Sergio, Birkholtz, Lyn-Marie, Chibale, Kelly

“…A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood…”
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Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00161a by Dziwornu, Godwin Akpeko, Kamunya, Stephanie, Ntsabo, Tando, Chibale, Kelly

“…Fusidic acid is a natural product antibiotic used clinically, primarily against staphylococcal infections. Fusidic acid is a natural product antibiotic used…”
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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy by Dziwornu, Godwin Akpeko, Seanego, Donald, Fienberg, Stephen, Clements, Monica, Ferreira, Jasmin, Sypu, Venkata S., Samanta, Sauvik, Bhana, Ashlyn D., Korkor, Constance M., Garnie, Larnelle F., Teixeira, Nicole, Wicht, Kathryn J., Taylor, Dale, Olckers, Ronald, Njoroge, Mathew, Gibhard, Liezl, Salomane, Nicolaas, Wittlin, Sergio, Mahato, Rohit, Chakraborty, Arnish, Sevilleno, Nicole, Coyle, Rachael, Lee, Marcus C. S., Godoy, Luiz C., Pasaje, Charisse Flerida, Niles, Jacquin C., Reader, Janette, van der Watt, Mariette, Birkholtz, Lyn-Marié, Bolscher, Judith M., de Bruijni, Marloes H. C., Coulson, Lauren B., Basarab, Gregory S., Ghorpade, Sandeep R., Chibale, Kelly

“…Structure–activity relationship studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors of Plasmodium falciparum (Pf)…”
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Antimalarial Pyrido[1,2‑a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies by Okombo, John, Brunschwig, Christel, Singh, Kawaljit, Dziwornu, Godwin Akpeko, Barnard, Linley, Njoroge, Mathew, Wittlin, Sergio, Chibale, Kelly

“…A novel series of pyrido­[1,2-a]­benzimidazoles bearing Mannich base side chains and their metabolites were synthesized and evaluated for in…”
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Pharmacokinetics and Organ Distribution of C‑3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid by Strydom, Natasha, Kaur, Gurminder, Dziwornu, Godwin Akpeko, Okombo, John, Wiesner, Lubbe, Chibale, Kelly

“…Fusidic acid (FA) has previously been shown to be rapidly metabolized in rodents to its C-3 epimer, which has significantly lower antimycobacterial activity…”
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