Search Results - "Dzierozynski, Lindsey"
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Uridine-derived ribose fuels glucose-restricted pancreatic cancer
Published in Nature (London) (01-06-2023)“…Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy 1 , 2 . This is mediated in part by a complex tumour…”
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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis
Published in eLife (31-05-2023)“…Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge…”
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Subtle, persistent shaping of the gut microbiome by host genes: A critical determinant of host biology
Published in Cell host & microbe (11-10-2023)“…Although environmental impacts on the host microbiome have been well studied, it is less certain whether and how host genetics impact the microbiome. This…”
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Abstract B003: Pancreatic cancer cells activate arginine biosynthesis to adapt to myeloid-driven amino acid stress in the tumor microenvironment
Published in Cancer research (Chicago, Ill.) (15-11-2022)“…Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs to maintain survival and proliferation. Therefore,…”
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Abstract PR10: Uridine-to-ribose axis supports glucose-restricted pancreatic cancer
Published in Cancer research (Chicago, Ill.) (16-01-2024)“…Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with a 5-year survival rate of 12% in the USA. PDA highly rely on glucose but is surrounded by a…”
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