Search Results - "Dzhemilev, Usein M."
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1
Metal Complex Catalysis in the Synthesis of Spirocarbocycles
Published in Chemical reviews (11-06-2014)“…The authors examine the metal complex catalysis in the synthesis of spirocarbocycles…”
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2
Synthesis of New Functionally Substituted 9-Azabicyclo[4.2.1]nona-2,4,7-trienes by Cobalt(I)-Catalyzed [6π + 2π]-Cycloaddition of N -Carbocholesteroxyazepine to Alkynes
Published in Molecules (Basel, Switzerland) (14-05-2021)“…Catalytic [6π + 2π]-cycloaddition of -carbocholesteroxyazepine with functionally substituted terminal alkynes and 1,4-butynediol was performed for the first…”
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3
(5Z,9Z)-14-[(3,28-Dioxoolean-12-en-28-yl)oxy]tetradeca-5,9-dienoic Acid with Cytotoxic Activity
Published in MolBank (01-03-2024)“…For the first time, a synthetic analogue of natural (5Z,9Z)-dienoic acid has been synthesized in the form of a hybrid molecule containing a fragment of…”
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4
Direct Synthesis of Polyaromatic Cyclophanes Containing Bis-Methylene-Interrupted Z-Double Bonds and Study of Their Antitumor Activity In Vitro
Published in International journal of molecular sciences (16-08-2021)“…An original synthetic route was developed for the preparation of previously unknown unsaturated polyaromatic macrolactones containing a 1Z,5Z-diene moiety in…”
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5
NbCl5-Mg Reagent System in Regio- and Stereoselective Synthesis of (2Z)-Alkenylamines and (3Z)-Alkenylols from Substituted 2-Alkynylamines and 3-Alkynylols
Published in Molecules (Basel, Switzerland) (18-06-2021)“…The reduction of N,N-disubstituted 2-alkynylamines and substituted 3-alkynylols using the NbCl5–Mg reagent system affords the corresponding dideuterated…”
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6
Comparative in vitro Studies of the Topoisomerase I Inhibition and Anticancer Activities of Metallated N‐Confused Porphyrins and Metallated Porphyrins
Published in ChemMedChem (03-04-2020)“…Using the original approach, a series of metallated N‐confused porphyrins and metallated porphyrins have been synthesized and characterized. For all the…”
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7
Synthesis of Spiro[2.2]pentanes and Spiro[2.3]hexanes Employing the Me3Al/CH2I2 Reagent
Published in European journal of organic chemistry (22-12-2017)“…Substituted alkylidenecyclopropanes reacted with 5 equivalents each of Me3Al and CH2I2 at room temperature in hexane to give 1‐mono‐ and 1,1‐disubstituted…”
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8
(3-(1H-Indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) with Cytotoxic Activity
Published in MolBank (01-03-2023)“…An efficient method for the synthesis of 3-(1H-indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) via condensation of…”
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9
Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
Published in Beilstein journal of organic chemistry (18-11-2019)“…We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further…”
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10
New Polyether Macrocycles as Promising Antitumor AgentsTargeted Synthesis and Induction of Mitochondrial Apoptosis
Published in ACS omega (07-05-2024)“…A series of previously unknown aromatic polyether macrodiolides containing a cis,cis-1,5-diene moiety in the molecule were synthesized in 47–74% yields…”
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11
Novel Hybrid Molecules on the Basis of Steroids and (5Z,9Z)-Tetradeca-5,9-dienoic Acid: Synthesis, Anti-Cancer Studies and Human Topoisomerase I Inhibitory Activity
Published in Anti-cancer agents in medicinal chemistry (01-07-2017)“…Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy…”
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12
Synthesis and Anticancer Activity of Hybrid Molecules Based on Lithocholic and (5 Z ,9 Z )-Tetradeca-5,9-dienedioic Acids Linked via Mono(di,tri,tetra)ethylene Glycol and α,ω-Diaminoalkane Units
Published in Pharmaceuticals (Basel, Switzerland) (23-01-2021)“…For the first time, hybrid molecules were synthesized on the basis of lithocholic and (5 ,9 )-1,14-tetradeca-5,9-dienedicarboxylic acids, obtained in two…”
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13
Natural Acetogenins, Chatenaytrienins-1, -2, -3 and -4, Mitochondrial Potential Uncouplers and Autophagy Inducers—Promising Anticancer Agents
Published in Antioxidants (30-07-2023)“…The present paper details the complete stereoselective synthesis of four natural acetogenins, chatenaytrienins-1, -2, -3 and -4, previously isolated from the…”
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14
Cobalt(I)-Catalyzed [6π + 2π] Cycloaddition of 1,2-Dienes and 1,3-Diynes to N‑Carbocholesteroxyazepine in the Synthesis of Previously Undescribed Heterofunctional 9‑Azabicyclo[4.2.1]nonadi(tri)enes
Published in ACS omega (24-08-2021)“…Promising heterofunctional (E)-9-azabicyclo[4.2.1]nona-2,4-dienes (79–92%) and 9-azabicyclo[4.2.1]nona-2,4,7-trienes (77–90%) containing a cholesterol…”
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15
Synthesis of Functionally Substituted Bicyclo[4.2.1]nona-2,4-dienes and Bicyclo[4.2.1]nona-2,4,7-trienes by Cobalt(I)-catalyzed [6π + 2π] Cycloaddition of 2‑Tropylcyclohexanone
Published in ACS omega (08-12-2020)“…The [6π + 2π] cycloaddition of 2-tropylcyclohexanone to allenes and alkynes was accomplished for the first time using the three-component catalytic system…”
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16
Ti-Catalyzed Cross-Cyclomagnesiation of 1,2-Dienes in the Total Z,Z,Z‑Stereoselective Synthesis of Natural Acetogenin–Chatenaytrienin‑1
Published in ACS omega (27-08-2019)“…The first total synthesis of natural acetogenin, chatenaytrienin-1, was performed in 10 steps and in 41% overall yield using cross-cyclomagnesiation of…”
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17
11-Phenylundeca-5Z,9Z-dienoic Acid: Stereoselective Synthesis and Dual Topoisomerase I/IIα Inhibition
Published in Current cancer drug targets (01-08-2015)“…(5Z,9Z)-11-Phenylundeca-5,9-dienoic acid was stereoselectively synthesized, based on original cross-cyclomagnesiation of…”
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18
Synthesis of New Cu Complex Based on Natural 5Z,9Z‑Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line
Published in ACS omega (22-10-2019)“…The complex (bipy)2Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)2 with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper…”
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19
Aluminacyclopentanes in the synthesis of 3-substituted phospholanes and α,ω-bisphospholanes
Published in Beilstein journal of organic chemistry (02-03-2016)“…An efficient one-pot process for the synthesis of 3-substituted phospholanes and α,ω-bisphospholanes was developed. The method involves the replacement of…”
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20
New 1,3-Diynoic Derivatives of Natural Lembehyne B: Stereoselective Synthesis, Anticancer, and Neuritogenic Activity
Published in ACS omega (04-02-2020)“…An original method has been developed for the synthesis of 1,3-dyine derivatives of natural lembehyne B in high yields (50–67%) and with high selectivity…”
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