Search Results - "Dzeja, Petras P."
-
1
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
Published in Cell stem cell (02-11-2012)“…Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support,…”
Get full text
Journal Article -
2
Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
Published in Cell metabolism (03-08-2011)“…The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains largely unknown. Here, stemness factor-mediated nuclear…”
Get full text
Journal Article -
3
Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease
Published in PloS one (29-02-2012)“…The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve…”
Get full text
Journal Article -
4
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module
Published in Nature communications (02-11-2020)“…Axonemal dynein ATPases direct ciliary and flagellar beating via adenosine triphosphate (ATP) hydrolysis. The modulatory effect of adenosine monophosphate…”
Get full text
Journal Article -
5
Phosphotransfer networks and cellular energetics
Published in Journal of experimental biology (01-06-2003)“…Precise coupling of spatially separated intracellular ATP-producing and ATP-consuming processes is fundamental to the bioenergetics of living organisms,…”
Get full text
Journal Article -
6
Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
Published in Nature clinical practice cardiovascular medicine (01-02-2007)“…Cardiogenesis within embryos or associated with heart repair requires stem cell differentiation into energetically competent, contracting cardiomyocytes. While…”
Get full text
Journal Article -
7
Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation
Published in Journal of molecular and cellular cardiology (01-04-2010)“…Abstract Decoding of the bioenergetic signature underlying embryonic stem cell cardiac differentiation has revealed a mandatory transformation of the metabolic…”
Get full text
Journal Article -
8
Energy metabolism plasticity enables stemness programs
Published in Annals of the New York Academy of Sciences (01-04-2012)“…Engineering pluripotency through nuclear reprogramming and directing stem cells into defined lineages underscores cell fate plasticity. Acquisition of and…”
Get full text
Journal Article -
9
Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation
Published in PloS one (27-04-2011)“…Energetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase…”
Get full text
Journal Article -
10
Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation
Published in Cell metabolism (04-09-2018)“…Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages, whereas enhanced fatty acid oxidation and oxidative phosphorylation are…”
Get full text
Journal Article -
11
Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation
Published in American journal of physiology. Heart and circulatory physiology (01-02-2002)“…K(+) channel openers have been recently recognized for their ability to protect mitochondria from anoxic injury. Yet the mechanism responsible for…”
Get more information
Journal Article -
12
Defective Metabolic Signaling in Adenylate Kinase AK1 Gene Knock-out Hearts Compromises Post-ischemic Coronary Reflow
Published in The Journal of biological chemistry (26-10-2007)“…Matching blood flow to myocardial energy demand is vital for heart performance and recovery following ischemia. The molecular mechanisms responsible for…”
Get full text
Journal Article -
13
Kir6.2 Is Required for Adaptation to Stress
Published in Proceedings of the National Academy of Sciences - PNAS (01-10-2002)“…Reaction to stress requires feedback adaptation of cellular functions to secure a response without distress, but the molecular order of this process is only…”
Get full text
Journal Article -
14
Adenylate Kinase Phosphotransfer Communicates Cellular Energetic Signals to ATP-Sensitive Potassium Channels
Published in Proceedings of the National Academy of Sciences - PNAS (19-06-2001)“…Transduction of energetic signals into membrane electrical events governs vital cellular functions, ranging from hormone secretion and cytoprotection to…”
Get full text
Journal Article -
15
Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function
Published in The American journal of physiology (01-11-1998)“…Discovered in the cardiac sarcolemma, ATP-sensitive K+ (KATP) channels have more recently also been identified within the inner mitochondrial membrane. Yet the…”
Get full text
Journal Article -
16
Energetic Communication between Mitochondria and Nucleus Directed by Catalyzed Phosphotransfer
Published in Proceedings of the National Academy of Sciences - PNAS (23-07-2002)“…Exchange of information between the nucleus and cytosol depends on the metabolic state of the cell, yet the energy-supply pathways to the nuclear compartment…”
Get full text
Journal Article -
17
Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection
Published in American journal of physiology. Heart and circulatory physiology (01-04-2003)“…Modulation of mitochondrial respiratory chain, dehydrogenase, and nucleotide-metabolizing enzyme activities is fundamental to cellular protection. Here, we…”
Get more information
Journal Article -
18
Phosphotransfer reactions in the regulation of ATP‐sensitive K+ channels
Published in The FASEB journal (01-05-1998)“…ATP‐sensitive K+ (KATP) channels are nucleotide‐gated channels that couple the metabolic status of a cell with membrane excitability and regulate a number of…”
Get full text
Journal Article -
19
Impaired Intracellular Energetic Communication in Muscles from Creatine Kinase and Adenylate Kinase (M-CK/AK1) Double Knock-out Mice
Published in The Journal of biological chemistry (15-08-2003)“…Previously we demonstrated that efficient coupling between cellular sites of ATP production and ATP utilization, required for optimal muscle performance, is…”
Get full text
Journal Article -
20
Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability
Published in American journal of physiology. Heart and circulatory physiology (01-04-2003)“…The failing ventricular myocardium is characterized by reduction of high-energy phosphates and reduced activity of the phosphotransfer enzymes creatine kinase…”
Get more information
Journal Article