Search Results - "Dzeja, Petras P."

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  1. 1

    Metabolic Plasticity in Stem Cell Homeostasis and Differentiation by Folmes, Clifford D.L., Dzeja, Petras P., Nelson, Timothy J., Terzic, Andre

    Published in Cell stem cell (02-11-2012)
    “…Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support,…”
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    Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming by Folmes, Clifford D.L., Nelson, Timothy J., Martinez-Fernandez, Almudena, Arrell, D. Kent, Lindor, Jelena Zlatkovic, Dzeja, Petras P., Ikeda, Yasuhiro, Perez-Terzic, Carmen, Terzic, Andre

    Published in Cell metabolism (03-08-2011)
    “…The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains largely unknown. Here, stemness factor-mediated nuclear…”
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    Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease by Trushina, Eugenia, Nemutlu, Emirhan, Zhang, Song, Christensen, Trace, Camp, Jon, Mesa, Janny, Siddiqui, Ammar, Tamura, Yasushi, Sesaki, Hiromi, Wengenack, Thomas M, Dzeja, Petras P, Poduslo, Joseph F

    Published in PloS one (29-02-2012)
    “…The identification of early mechanisms underlying Alzheimer's Disease (AD) and associated biomarkers could advance development of new therapies and improve…”
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    Phosphotransfer networks and cellular energetics by Dzeja, Petras P, Terzic, Andre

    Published in Journal of experimental biology (01-06-2003)
    “…Precise coupling of spatially separated intracellular ATP-producing and ATP-consuming processes is fundamental to the bioenergetics of living organisms,…”
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    Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells by Chung, Susan, Dzeja, Petras P, Faustino, Randolph S, Perez-Terzic, Carmen, Behfar, Atta, Terzic, Andre

    “…Cardiogenesis within embryos or associated with heart repair requires stem cell differentiation into energetically competent, contracting cardiomyocytes. While…”
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    Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation by Chung, Susan, Arrell, D. Kent, Faustino, Randolph S, Terzic, Andre, Dzeja, Petras P

    “…Abstract Decoding of the bioenergetic signature underlying embryonic stem cell cardiac differentiation has revealed a mandatory transformation of the metabolic…”
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  8. 8

    Energy metabolism plasticity enables stemness programs by Folmes, Clifford D.L., Nelson, Timothy J., Dzeja, Petras P., Terzic, Andre

    Published in Annals of the New York Academy of Sciences (01-04-2012)
    “…Engineering pluripotency through nuclear reprogramming and directing stem cells into defined lineages underscores cell fate plasticity. Acquisition of and…”
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    Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation by Dzeja, Petras P, Chung, Susan, Faustino, Randolph S, Behfar, Atta, Terzic, Andre

    Published in PloS one (27-04-2011)
    “…Energetic and metabolic circuits that orchestrate cell differentiation are largely unknown. Adenylate kinase (AK) and associated AMP-activated protein kinase…”
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  10. 10

    Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation by Wang, Feilong, Zhang, Song, Vuckovic, Ivan, Jeon, Ryounghoon, Lerman, Amir, Folmes, Clifford D., Dzeja, Petras P., Herrmann, Joerg

    Published in Cell metabolism (04-09-2018)
    “…Enhanced glucose uptake and a switch to glycolysis are key traits of M1 macrophages, whereas enhanced fatty acid oxidation and oxidative phosphorylation are…”
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    Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation by Ozcan, Cevher, Bienengraeber, Martin, Dzeja, Petras P, Terzic, Andre

    “…K(+) channel openers have been recently recognized for their ability to protect mitochondria from anoxic injury. Yet the mechanism responsible for…”
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  12. 12

    Defective Metabolic Signaling in Adenylate Kinase AK1 Gene Knock-out Hearts Compromises Post-ischemic Coronary Reflow by Dzeja, Petras P., Bast, Peter, Pucar, Darko, Wieringa, Be, Terzic, Andre

    Published in The Journal of biological chemistry (26-10-2007)
    “…Matching blood flow to myocardial energy demand is vital for heart performance and recovery following ischemia. The molecular mechanisms responsible for…”
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    Kir6.2 Is Required for Adaptation to Stress by Zingman, Leonid V., Hodgson, Denice M., Bast, Peter H., Kane, Garvan C., Perez-Terzic, Carmen, Gumina, Richard J., Pucar, Darko, Bienengraeber, Martin, Dzeja, Petras P., Miki, Takashi, Seino, Susumu, Alekseev, Alexey E., Terzic, Andre

    “…Reaction to stress requires feedback adaptation of cellular functions to secure a response without distress, but the molecular order of this process is only…”
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    Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial function by Holmuhamedov, E L, Jovanović, S, Dzeja, P P, Jovanović, A, Terzic, A

    Published in The American journal of physiology (01-11-1998)
    “…Discovered in the cardiac sarcolemma, ATP-sensitive K+ (KATP) channels have more recently also been identified within the inner mitochondrial membrane. Yet the…”
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    Energetic Communication between Mitochondria and Nucleus Directed by Catalyzed Phosphotransfer by Dzeja, Petras P., Bortolon, Ryan, Perez-Terzic, Carmen, Holmuhamedov, Ekshon L., Terzic, Andre

    “…Exchange of information between the nucleus and cytosol depends on the metabolic state of the cell, yet the energy-supply pathways to the nuclear compartment…”
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    Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection by Dzeja, Petras P, Bast, Peter, Ozcan, Cevher, Valverde, Arturo, Holmuhamedov, Ekshon L, Van Wylen, David G L, Terzic, Andre

    “…Modulation of mitochondrial respiratory chain, dehydrogenase, and nucleotide-metabolizing enzyme activities is fundamental to cellular protection. Here, we…”
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    Phosphotransfer reactions in the regulation of ATP‐sensitive K+ channels by Dzeja, Petras P., Terzic, Andre

    Published in The FASEB journal (01-05-1998)
    “…ATP‐sensitive K+ (KATP) channels are nucleotide‐gated channels that couple the metabolic status of a cell with membrane excitability and regulate a number of…”
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    Impaired Intracellular Energetic Communication in Muscles from Creatine Kinase and Adenylate Kinase (M-CK/AK1) Double Knock-out Mice by Janssen, Edwin, Terzic, Andre, Wieringa, Bé, Dzeja, Petras P.

    Published in The Journal of biological chemistry (15-08-2003)
    “…Previously we demonstrated that efficient coupling between cellular sites of ATP production and ATP utilization, required for optimal muscle performance, is…”
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    Failing atrial myocardium: energetic deficits accompany structural remodeling and electrical instability by Cha, Yong-Mei, Dzeja, Petras P, Shen, Win K, Jahangir, Arshad, Hart, Chari Y T, Terzic, Andre, Redfield, Margaret M

    “…The failing ventricular myocardium is characterized by reduction of high-energy phosphates and reduced activity of the phosphotransfer enzymes creatine kinase…”
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