Search Results - "Dyson, H"

NMR illuminates intrinsic disorder by Dyson, H. Jane, Wright, Peter E.

“…Nuclear magnetic resonance (NMR) has long been instrumental in the characterization of intrinsically disordered proteins (IDPs) and intrinsically disordered…”
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Making Sense of Intrinsically Disordered Proteins by Dyson, H. Jane

“…Proteins form the molecular scaffolding of life and are essential to catalyzing the chemical reactions that sustain living systems. These characteristics have…”
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Vital for Viruses: Intrinsically Disordered Proteins by Dyson, H. Jane

“…[Display omitted] •The minimal genetic material of viruses must be used with the utmost efficiency.•One efficient tactic is to use IDPs to hijack cellular…”
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Intrinsically disordered proteins in cellular signalling and regulation by Wright, Peter E., Dyson, H. Jane

“…Key Points Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins that may also contain structured domains mediate…”
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Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300 by Dyson, H. Jane, Wright, Peter E.

“…The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered…”
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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain by Krois, Alexander S., Dyson, H. Jane, Wright, Peter E.

“…Atomic resolution characterization of the full-length p53 tetramer has been hampered by its size and the presence of extensive intrinsically disordered regions…”
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Ave atque vale by Dyson, H. Jane

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Early Strides in NMR Dynamics Measurements by Dyson, H. Jane

“…The study of protein dynamics using the measurement of relaxation times by NMR was based on a set of studies in the mid-20th century that outlined theories and…”
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More pandemic reflections by Dyson, H. Jane

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Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding by Arai, Munehito, Sugase, Kenji, Dyson, H. Jane, Wright, Peter E.

“…Intrinsically disordered proteins (IDPs) frequently function in protein interaction networks that regulate crucial cellular signaling pathways. Many IDPs…”
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Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…Allosteric regulatory processes are implicated at all levels of biological function. Recent advances in our understanding of the diverse and functionally…”
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Hypersensitive termination of the hypoxic response by a disordered protein switch by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…The intrinsically disordered CITED2 negative feedback regulator displaces the tightly bound hypoxia-inducible transcription factor HIF-1α from their common…”
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Diversity at BJ: The editors, the reviewers, the authors by Dyson, H. Jane

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Linking folding and binding by Wright, Peter E, Dyson, H Jane

“…Many cellular proteins are intrinsically disordered and undergo folding, in whole or in part, upon binding to their physiological targets. The past few years…”
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Reflections on the Pandemic by Dyson, H. Jane

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Functional advantages of dynamic protein disorder by Berlow, Rebecca B., Dyson, H. Jane, Wright, Peter E.

“…Intrinsically disordered proteins participate in many important cellular regulatory processes. The absence of a well-defined structure in the free state of a…”
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A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding by Sun, Xun, Dyson, H. Jane, Wright, Peter E.

“…The tumor-suppressor p53 is a critical regulator of the cellular response to DNA damage and is tightly regulated by posttranslational modifications. Thr55 in…”
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Kinetic analysis of the multistep aggregation pathway of human transthyretin by Sun, Xun, Dyson, H. Jane, Wright, Peter E.

“…Aggregation of transthyretin (TTR) is the causative agent for TTR cardiomyopathy and polyneuropathy amyloidoses. Aggregation is initiated by dissociation of…”
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Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins by Dyson, H. Jane, Wright, Peter E.

“…The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered…”
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Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins by Berlow, Rebecca B, Dyson, H Jane, Wright, Peter E

“…Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the…”
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