Search Results - "Dyrager, Christine"

Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis by Karlsson, Elin, Magić, Ivana, Bostner, Josefine, Dyrager, Christine, Lysholm, Fredrik, Hallbeck, Anna-Lotta, Stål, Olle, Lundström, Patrik

“…The AKT/mTORC1/S6K pathway is frequently overstimulated in breast cancer, constituting a promising therapeutic target. The benefit from mTOR inhibitors varies,…”
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Synthesis of 2-Alkyl-Substituted Chromone Derivatives Using Microwave Irradiation by Fridén-Saxin, Maria, Pemberton, Nils, da Silva Andersson, Krystle, Dyrager, Christine, Friberg, Annika, Grøtli, Morten, Luthman, Kristina

“…A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford…”
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Prevalent Bioimaging Scaffolds: Synthesis, Photophysical Properties and Applications by Colas, Kilian, Doloczki, Susanne, Posada Urrutia, Mauricio, Dyrager, Christine

“…This minireview describes the syntheses, structure‐photophysical properties relationship, and bioimaging applications of fluorescent coumarins, xanthenes,…”
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Tuning the Emission Properties of 2,1,3‐Benzothiadiazoles via Regioselective Substitution by Posada Urrutia, Mauricio, Dyrager, Christine

“…The 2,1,3‐benzothiadiazole (BTD) unit is a prominent building block commonly used in various research areas such as optoelectronics and bioimaging. Despite its…”
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Photoinduced Ring-Opening and Phototoxicity of an Indolin-3-one Derivative by Doloczki, Susanne, Kern, Christoph, Holmberg, Karl O, Swartling, Fredrik J, Streuff, Jan, Dyrager, Christine

“…The study of a fluorescent indolin-3-one derivative is reported that, as opposed to its previously described congeners, selectively undergoes photoactivated…”
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Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease by Jones, Michael R, Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V, Tsutsui, Shigeki, Stys, Peter K, Storr, Tim

“…Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular…”
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Specific Imaging of Intracellular Lipid Droplets Using a Benzothiadiazole Derivative with Solvatochromic Properties by Appelqvist, Hanna, Stranius, Kati, Börjesson, Karl, Nilsson, K. Peter. R, Dyrager, Christine

“…Altered lipid metabolism and extensive lipid storage in cells have been associated with various medical disorders, including cancer. The development of…”
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Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells by Colas, Kilian, Holmberg, Karl O, Chiang, Linus, Doloczki, Susanne, Swartling, Fredrik J, Dyrager, Christine

“…We present an extensive photophysical study of a series of fluorescent indolylbenzothiadiazole derivatives and their ability to specifically image lipid…”
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Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity by Kunz, Susanna, Barnå, Fredrik, Urrutia, Mauricio Posada, Ingner, Fredric J. L., Martínez-Topete, Andrea, Orthaber, Andreas, Gates, Paul J., Pilarski, Lukasz T., Dyrager, Christine

“…Despite growing interest in 2,1,3-benzothiadiazole (BTD) as an integral component of many functional molecules, methods for the functionalization of its…”
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Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma by Sainero-Alcolado, Lourdes, Garde-Lapido, Elisa, Snaebjörnsson, Marteinn Thor, Schoch, Sarah, Stevens, Irene, Ruiz-Pérez, María Victoria, Dyrager, Christine, Pelechano, Vicent, Axelson, Håkan, Schulze, Almut, Arsenian-Henriksson, Marie

“…Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs),…”
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Photophysical characterization and fluorescence cell imaging applications of 4- N -substituted benzothiadiazoles by Doloczki, Susanne, Holmberg, Karl O, Fdez Galván, Ignacio, Swartling, Fredrik J, Dyrager, Christine

“…In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various -substituents in the 4-position was synthesized and photophysically…”
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An Indolin‐3‐imine Photobase and pH Sensitive Fluorophore by Doloczki, Susanne, Kern, Christoph, Holmberg, Karl O., Zhao, Miao, Swartling, Fredrik J., Streuff, Jan, Dyrager, Christine

“…This work presents the pH sensing ability of a fluorescent indolin‐3‐imine derivative. Protonation of the weakly basic imine (pKa=8.3 of its conjugate acid)…”
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8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation by Gomes, Luiza M.F., Vieira, Rafael P., Jones, Michael R., Wang, Michael C.P., Dyrager, Christine, Souza-Fagundes, Elaine M., Da Silva, Jeferson G., Storr, Tim, Beraldo, Heloisa

“…One of the hallmarks of Alzheimer's disease (AD) in the brain are amyloid-β (Aβ) plaques, and metal ions such as copper(II) and zinc(II) have been shown to…”
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Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation by Jones, Michael R., Dyrager, Christine, Hoarau, Marie, Korshavn, Kyle J., Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Storr, Tim

“…Metal ion dyshomeostasis is hypothesized to play a role in the toxicity and aggregation of the amyloid beta (Aβ) peptide, contributing to Alzheimer's disease…”
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Photophysical characterization and fluorescence cell imaging applications of 4--substituted benzothiadiazoles by Doloczki, Susanne, Holmberg, Karl O, Fdez. Galván, Ignacio, Swartling, Fredrik J, Dyrager, Christine

“…In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N -substituents in the 4-position was synthesized and photophysically…”
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Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors by Dyrager, Christine, Möllers, Linda Nilsson, Kjäll, Linda Karlsson, Alao, John Patrick, Dinér, Peter, Wallner, Fredrik K, Sunnerhagen, Per, Grøtli, Morten

“…3-(4-Fluorophenyl)-2-(4-pyridyl)chromone derivatives were synthesized and evaluated as p38 MAP kinase inhibitors. Introduction of an amino group in the…”
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Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents by Dyrager, Christine, Wickström, Malin, Fridén-Saxin, Maria, Friberg, Annika, Dahlén, Kristian, Wallén, Erik A.A., Gullbo, Joachim, Grøtli, Morten, Luthman, Kristina

“…A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different…”
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Photophysical Characteristics of Polarity‐Sensitive and Lipid Droplet‐Specific Phenylbenzothiadiazoles by Colas, Kilian, Doloczki, Susanne, Kesidou, Aikaterina, Sainero‐Alcolado, Lourdes, Rodriguez‐Garcia, Aida, Arsenian‐Henriksson, Marie, Dyrager, Christine

“…In this study, we present a series of solvatochromic phenylbenzothiadiazoles that display dual emission from the locally excited (LE) and intramolecular charge…”
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Chroman-4-one and chromone based somatostatin β-turn mimetics by Fridén-Saxin, Maria, Seifert, Tina, Malo, Marcus, da Silva Andersson, Krystle, Pemberton, Nils, Dyrager, Christine, Friberg, Annika, Dahlén, Kristian, Wallén, Erik A.A., Grøtli, Morten, Luthman, Kristina

“…A scaffold approach has been used to develop somatostatin β-turn mimetics based on chroman-4-one and chromone ring systems. Such derivatives could adopt…”
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Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's diseaseElectronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01269a by Jones, Michael R, Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J, Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V, Tsutsui, Shigeki, Stys, Peter K, Storr, Tim

“…Alzheimer's disease (AD) is a multifactorial disease that is characterized by the formation of intracellular neurofibrillary tangles and extracellular…”
Get full text