Search Results - "Dymock, Brian William"
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Hydrogen sulfide promotes adipogenesis in 3T3L1 cells
Published in PloS one (30-03-2015)“…The effect of hydrogen sulfide (H2S) on differentiation of 3T3L1-derived adipocytes was examined. Endogenous H2S was increased after 3T3L1 differentiation. The…”
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Intranasal administration of a stapled relaxin‐3 mimetic has anxiolytic‐ and antidepressant‐like activity in rats
Published in British journal of pharmacology (01-10-2019)“…Background and Purpose Depression and anxiety are common causes of disability, and innovative tools and potential pharmacological targets are actively sought…”
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Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity
Published in Peptides (New York, N.Y. : 1980) (01-10-2016)“…•Relaxin-3 binds and activates the receptor RXFP3 through its B chain, which is stabilised in an alpha-helical conformation by a disulphide bonded A chain.•The…”
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85: Identification of novel hydrogen sulfide (H2S) donors with controlled release rates that elicit anti-inflammatory effects in RAW264.7 cells
Published in Cytokine (Philadelphia, Pa.) (01-11-2014)“…Whether hydrogen sulfide (H2S) exhibits pro- or anti-inflammatory activity is not clear [1]. To date, ‘fast-releasing H2S donors’ like NaHS (release in…”
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Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria
Published in Frontiers in microbiology (07-09-2016)“…Reactive multi-target 'fragment drugs' represent critical components of current tuberculosis regimens. These compounds, such as pyrazinamide, are old synthetic…”
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P28 Identification of a novel slow-releasing hydrogen sulfide donor for cancer therapy
Published in Nitric oxide (01-09-2013)“…It has previously been reported that hydrogen sulfide (H2S) exerts both pro- and anti-apoptotic activity in different cultured cells [1–3]. However, the…”
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A Novel Asymmetric [2+2] Cycloaddition and Its Application to the Total Synthesis of 1233A
Published 01-01-1997“…The first enantioselective [2+2] cycloaddition of aldehydes with (trimethylsilyl)ketene is discovered and developed using chirally modified Lewis acids. In…”
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Dissertation