Search Results - "Dykes, Samantha"

Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling by Tanaka, Mai, Dykes, Samantha S., Siemann, Dietmar W.

“…Approximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell…”
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Supporting a role for the GTPase Rab7 in prostate cancer progression by Steffan, Joshua J, Dykes, Samantha S, Coleman, David T, Adams, Lisa K, Rogers, Donna, Carroll, Jennifer L, Williams, B Jill, Cardelli, James A

“…Invasion and subsequent metastasis is the major cause of death from most cancers including prostate cancer. Herein we report on the potential tumor suppressive…”
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A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion by Circu, Magdalena L, Dykes, Samantha S, Carroll, Jennifer, Kelly, Kinsey, Galiano, Floyd, Greer, Adam, Cardelli, James, El-Osta, Hazem

“…Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have…”
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Cathepsin L secretion by host and neoplastic cells potentiates invasion by Dykes, Samantha S, Fasanya, Henrietta O, Siemann, Dietmar W

“…The presence of macrophages within breast tumors correlates with metastatic potential. These tumor-associated macrophages often take on a pro-tumorigenic…”
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Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers by Dykes, Samantha S, Steffan, Joshua J, Cardelli, James A

“…Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte…”
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The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo by Dykes, Samantha S, Gray, Alana L, Coleman, David T, Saxena, Madhurima, Stephens, Charles A, Carroll, Jennifer L, Pruitt, Kevin, Cardelli, James A

“…Cancer is a multistep process that requires cells to respond appropriately to the tumor microenvironment, both in early proliferative stages and in later…”
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Stromal cells in breast cancer as a potential therapeutic target by Dykes, Samantha S, Hughes, Veronica S, Wiggins, Jennifer M, Fasanya, Henrietta O, Tanaka, Mai, Siemann, Dietmar

“…Breast cancer in the United States is the second most commonly diagnosed cancer in women. About 1 in 8 women will develop invasive breast cancer over the…”
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Bioprinting on Live Tissue for Investigating Cancer Cell Dynamics by Suarez-Martinez, Ariana D, Sole-Gras, Marc, Dykes, Samantha S, Wakefield, Zachary R, Bauer, Kevin, Majbour, Dima, Bundy, Angela, Pampo, Christine, Burow, Matthew E, Siemann, Dietmar W, Huang, Yong, Murfee, Walter Lee

“…A challenge in cancer research is the lack of physiologically responsive models that enable tracking of cancer cells in tissue-like environments. A model that…”
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Correction: A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion by Circu, Magdalena L, Dykes, Samantha S, Carroll, Jennifer, Kelly, Kinsey, Galiano, Floyd, Greer, Adam, Cardelli, James, El-Osta, Hazem

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Zinc finger E‐box binding homeobox‐1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger‐1 (NHE1) by Dykes, Samantha S., Gao, ChongFeng, Songock, William K., Bigelow, Rebecca L., Woude, George Vande, Bodily, Jason M., Cardelli, James A.

“…Tumor cell invasion through the extracellular matrix is facilitated by the secretion of lysosome‐associated proteases. As a common mechanism for secretion,…”
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Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans by Tournu, Helene, Carroll, Jennifer, Latimer, Brian, Dragoi, Ana-Maria, Dykes, Samantha, Cardelli, James, Peters, Tracy L, Eberle, Karen E, Palmer, Glen E

“…The fungal vacuole is a large acidified organelle that performs a variety of cellular functions. At least a sub-set of these functions are crucial for…”
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The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity by Dykes, Samantha S., Friday, Ellen, Pruitt, Kevin, Cardelli, James A.

“…Common features of the solid tumor microenvironment, such as acidic extracellular pH and growth factors, are known to induce the redistribution of lysosomes…”
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Abstract 186: Small-molecule inhibition of cathepsins L and K as potential therapeutics for macrophage-driven breast cancer by Dykes, Samantha S., Siemann, Dietmar W.

“…Tumor-associated macrophages secrete many factors including proteases and growth factors, which ultimately promote the metastatic phenotype of mammary tumors…”
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Abstract 2952: The novel cathepsin L/K inhibitors KGP94 and KGP207 prevent M0 to M2 macrophage differentiation and macrophage-mediated pro-tumor functions by Dykes, Samantha S., Siemann, Dietmar W.

“…Tumor-associated macrophages play many important roles in tumor progression, including facilitating tumor cell invasion and angiogenesis. Due to their numerous…”
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Abstract 3759: Host and neoplastic cell secretions of proteolytic enzymes potentiate metastasis by Dykes, Samantha S., Fasanya, Henrietta O., Siemann, Dietmar W.

“…The presence of macrophages within breast tumors is associated with metastatic potential. Tumor-associated macrophages are often stimulated by Interleukin-4,…”
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Abstract 2507: Axl suppression inhibits cell migration, invasion and survival in breast and prostate cancer cell lines by Tanaka, Mai, Dykes, Samantha S., Siemann, Dietmar W.

“…Cancer is the second leading cause of death in the United States with approximately 90% of cancer-related deaths resulting from metastatic disease. In tumor…”
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Abstract A23: A novel tumor microenvironment model that combines bioprinting and tissue culture to investigate cancer cell and microvascular interactions by Suarez-Martinez, Ariana D., Sole-Gras, Marc, Dykes, Samantha S., Wakefield, Zachary R., Bauer, Kevin, Lampejo, Arinola, Siemann, Dietmar W., Huang, Yong, Murfee, Walter L.

“…A challenge in cancer research is the lack of a physiologically responsive in vitro model that allows for the investigation of cancer cells in a tissue-like…”
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A Novel Tumor Microenvironment Model that Combines Bioprinting and Tissue Culture to Investigate Cancer Cell and Microvascular Interactions by Suarez-Martinez, Ariana D., Sole-Gras, Marc, Dykes, Samantha S., Wakefield, Zachary R., Bauer, Kevin, Lampejo, Arinola, Siemann, Dietmar W., Huang, Yong, Murfee, Walter L.

“…Abstract only…”
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Epstein-Barr virus stably confers an invasive phenotype to epithelial cells through reprogramming of the WNT pathway by Birdwell, Christine E, Prasai, Kanchanjunga, Dykes, Samantha, Jia, Yali, Munroe, Tawsha G C, Bienkowska-Haba, Malgorzata, Scott, Rona S

“…Epstein-Barr virus (EBV)-associated carcinomas, such as nasopharyngeal carcinoma (NPC), exhibit an undifferentiated and metastatic phenotype. To determine…”
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Abstract 1071: Epidermal growth factor induces anterograde lysosome trafficking via activation of p38 by Dykes, Samantha S., Cardelli, James A.

“…Previous studies from our laboratory have demonstrated that acidic extracellular pH and activation of c-Met by the Hepatocyte Growth Factor (HGF) in the tumor…”
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