Search Results - "Dykens, James A."

The significance of mitochondrial toxicity testing in drug development by Dykens, James A., Will, Yvonne

“…Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities. Members of diverse drug classes undermine mitochondrial…”
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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro by Dykens, James A., Jamieson, Joseph, Marroquin, Lisa, Nadanaciva, Sashi, Billis, Puja A., Will, Yvonne

“…As a class, the biguanides induce lactic acidosis, a hallmark of mitochondrial impairment. To assess potential mitochondrial impairment, we evaluated the…”
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Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells by Will, Yvonne, Dykens, James A., Nadanaciva, Sashi, Hirakawa, Brad, Jamieson, Joseph, Marroquin, Lisa D., Hynes, James, Patyna, Shem, Jessen, Bart A.

“…Cardiovascular disease has recently been suggested to be a significant complication of cancer treatment with several kinase inhibitors. In some cases, the…”
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In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone by Dykens, James A., Jamieson, Joseph D., Marroquin, Lisa D., Nadanaciva, Sashi, Xu, Jinghai J., Dunn, Margaret C., Smith, Arthur R., Will, Yvonne

“…Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S…”
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Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration by Nadanaciva, Sashi, Dykens, James A., Bernal, Autumn, Capaldi, Roderick A., Will, Yvonne

“…Mitochondrial impairment is increasingly implicated in the etiology of toxicity caused by some thiazolidinediones, fibrates, and statins. We examined the…”
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Novel mechanisms for estrogen-induced neuroprotection by Singh, Meharvan, Dykens, James A, Simpkins, James W

“…Estrogens are gonadal steroid hormones that are present in the circulation of both males and females and that can no longer be considered within the strict…”
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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants by Marroquin, Lisa D., Hynes, James, Dykens, James A., Jamieson, Joseph D., Will, Yvonne

“…Many highly proliferative cells generate almost all ATP via glycolysis despite abundant O2 and a normal complement of fully functional mitochondria, a…”
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Mitochondrial mechanisms of estrogen neuroprotection by Simpkins, James W, Yi, Kun Don, Yang, Shao-Hua, Dykens, James A

“…Mitochondria have become a primary focus in our search not only for the mechanism(s) of neuronal death but also for neuroprotective drugs and therapies that…”
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Strategies to reduce late-stage drug attrition due to mitochondrial toxicity by Dykens, James A, Marroquin, Lisa D, Will, Yvonne

“…Mitochondrial dysfunction is increasingly implicated in the etiology of drug-induced toxicities and negative side-effect profiles. Early identification of…”
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Mitochondrial Drugs Come of Age by Moos, Walter H., Dykens, James A.

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Mitochondrial mechanisms of estrogen neuroprotection by Simpkins, James W, Dykens, James A

“…Abstract Oxidative stress, bioenergetic failure and mitochondrial dysfunction are all implicated in the etiology of neurodegenerative diseases such as…”
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Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration by Dykens, J A

“…The evidence is compelling that free radicals, plus increases in free cytosolic Ca2+ and Na+, figure prominently in neuronal death after exposure to glutamate…”
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Development of 17α-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study by DYKENS, JAMES A., MOOS, WALTER H., HOWELL, NEIL

“…: 17α‐estradiol (17α‐E2) differs from its isomer, the potent feminizing hormone 17β‐estradiol (17β‐E2), only in the stereochemistry at one carbon, but this is…”
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Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability by Wang, Xiaofei, Simpkins, James W, Dykens, James A, Cammarata, Patrick R

“…Epidemiologic studies demonstrate a higher incidence of cataracts in estrogen-deprived postmenopausal women, but the mechanism for the increased risk of…”
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Oxygen radical production in the sea anemone Anthopleura elegantissima and its endosymbiotic algae by DYKENS, J. A, SHICK, J. M, BENOIT, C, BUETTNER, G. R, WINSTON, G. W

“…Host animals in algal-invertebrate endosymbiotic associations are exposed to photosynthetically generated hyperoxia while in sunlight, conditions conducive to…”
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Mitochondria play a central role in estrogen-induced neuroprotection by Simpkins, James W, Wang, Jian, Wang, Xiaofei, Perez, Evelyn, Prokai, Laszlo, Dykens, James A

“…Oxidative stress, bioenergetic impairment and mitochondrial failure have all been implicated in the etiology of neurodegenerative diseases such as Alzheimer's…”
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Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential by Moos, Walter H., Dykens, James A., Nohynek, Dana, Rubinchik, Evelina, Howell, Neil

“…17α‐Estradiol is a less feminizing isomer of the potent hormonal estrogen, 17β‐estradiol. 17α‐Estradiol is an orally active small molecule with conflicting…”
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Development and validation of a pre-clinically relevant phototoxicity screen by Gandy, Graham J, Dykens, James A, Phillips, Gareth P

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Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog by Dykens, James A., Carroll, Amy K., Wiley, Sandra, Covey, Douglas F., Cai, Zu Yun, Zhao, Lian, Wen, Rong

“…The cytoprotective activity of MITO-4565, a novel, non-hormonal, estradiol derivative, was evaluated in the S334ter transgenic model of retinitis pigmentosa…”
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A current practice for predicting ocular toxicity of systemically delivered drugs by Somps, Chris J., Greene, Nigel, Render, James A., Aleo, Michael D., Fortner, Jay H., Dykens, James A., Phillips, Gareth

“…The ability to predict ocular side effects of systemically delivered drugs is an important issue for pharmaceutical companies. Although animal models involving…”
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